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Publikationer som ChEBI hänvisar till för GSK2879552. Visa hela publikationsregistret

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Publications in the selection

19 hits

Bibliografisk träff 2021-05-24

Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication.

Tu WJ, McCuaig RD, Melino M, Rawle DJ, Le TT, Yan K, Suhrbier A, Johnston RL, Koufariotis LT, Waddell N, Cross EM, Tsimbalyuk S, Bain A, Ahern E, Collinson N, Phipps S, Forwood JK, Seddiki N, Rao S.

Cell Discov · research-article; journal article · DOI 10.1038/s41421-021-00279-w

Bibliografisk träff 2021-03-25

LSD1 as a Biomarker and the Outcome of Its Inhibitors in the Clinical Trial: The Therapy Opportunity in Tumor.

Agboyibor C, Dong J, Effah CY, Drokow EK, Pervaiz W, Liu HM.

J Oncol · review-article; review; journal article · DOI 10.1155/2021/5512524

Bibliografisk träff 2021-02-23

LSD1 Promotes Prostate Cancer Cell Survival by Destabilizing FBXW7 at Post-Translational Level.

Qin XK, Du Y, Liu XH, Wang L.

Front Oncol · research-article; journal article · DOI 10.3389/fonc.2020.616185

Bibliografisk träff 2020-12-04

Targeting LSD1 for acute myeloid leukemia (AML) treatment.

Zhang S, Liu M, Yao Y, Yu B, Liu H.

Pharmacol Res · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.phrs.2020.105335

Bibliografisk träff 2020-09-30

Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective.

Dai XJ, Liu Y, Xiong XP, Xue LP, Zheng YC, Liu HM.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.0c00919

Bibliografisk träff 2020-07-28

LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT.

Xie Q, Tang T, Pang J, Xu J, Yang X, Wang L, Huang Y, Huang Z, Liu G, Tong D, Zhang Y, Wang L, Zhang D, Lan W, Liu Q, Jiang J.

Front Oncol · research-article; journal article · DOI 10.3389/fonc.2020.01234

Bibliografisk träff 2020-05-06

Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors.

Gehling VS, McGrath JP, Duplessis M, Khanna A, Brucelle F, Vaswani RG, Côté A, Stuckey J, Watson V, Cummings RT, Balasubramanian S, Iyer P, Sawant P, Good AC, Albrecht BK, Harmange JC, Audia JE, Bellon SF, Trojer P, Levell JR.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.0c00060

Bibliografisk träff 2019-12-04

LSD1/KDM1A inhibitors in clinical trials: advances and prospects.

Fang Y, Liao G, Yu B, Yu B.

J Hematol Oncol · research support, non-u.s. gov't; review-article; review; journal article · DOI 10.1186/s13045-019-0811-9

Bibliografisk träff 2019-06-28

Phase I, Open-Label, Dose-Escalation Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of GSK2879552 in Relapsed/Refractory SCLC.

Bauer TM, Besse B, Martinez-Marti A, Trigo JM, Moreno V, Garrido P, Ferron-Brady G, Wu Y, Park J, Collingwood T, Kruger RG, Mohammad HP, Ballas MS, Dhar A, Govindan R.

J Thorac Oncol · research support, non-u.s. gov't; multicenter study; clinical trial, phase i; journal article · DOI 10.1016/j.jtho.2019.06.021

Bibliografisk träff 2019-06-12

Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.

Tan AHY, Tu W, McCuaig R, Hardy K, Donovan T, Tsimbalyuk S, Forwood JK, Rao S.

Front Immunol · research support, non-u.s. gov't; research-article; journal article · DOI 10.3389/fimmu.2019.01351

Bibliografisk träff 2019-05-02

The Degradation Chemistry of GSK2879552: Salt Selection and Microenvironmental pH Modulation to Stabilize a Cyclopropyl Amine.

Campbell JM, Lee M, Clawson J, Kennedy-Gabb S, Bethune S, Janiga A, Kindon L, Leach KP.

J Pharm Sci · research support, non-u.s. gov't; journal article · DOI 10.1016/j.xphs.2019.04.026

Bibliografisk träff 2019-01-18

Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor.

Wang X, Su M, Li Y, Liu T, Wang Y, Chen Y, Tang L, He YP, Ding X, Yu F, Shen J, Li J, Zhou Y, Chen YL, Xiong B.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.01.017

Bibliografisk träff 2018-12-04

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-<i>trans</i> retinoic acid in acute myeloid leukemia across subtypes.

Smitheman KN, Severson TM, Rajapurkar SR, McCabe MT, Karpinich N, Foley J, Pappalardi MB, Hughes A, Halsey W, Thomas E, Traini C, Federowicz KE, Laraio J, Mobegi F, Ferron-Brady G, Prinjha RK, Carpenter CL, Kruger RG, Wessels L, Mohammad HP.

Haematologica · research-article; journal article · DOI 10.3324/haematol.2018.199190

Bibliografisk träff 2018-11-17

Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors.

Ma QS, Yao Y, Zheng YC, Feng S, Chang J, Yu B, Liu HM.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.11.035

Bibliografisk träff 2018-07-17

Selective DOT1L, LSD1, and HDAC Class I Inhibitors Reduce HOXA9 Expression in MLL-AF9 Rearranged Leukemia Cells, But Dysregulate the Expression of Many Histone-Modifying Enzymes.

Lillico R, Lawrence CK, Lakowski TM.

J Proteome Res · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jproteome.8b00118

Bibliografisk träff 2017-07-19

Advances toward LSD1 inhibitors for cancer therapy.

Fu X, Zhang P, Yu B.

Future Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.4155/fmc-2017-0068

Bibliografisk träff 2016-02-02

Recent Progress in Histone Demethylase Inhibitors.

McAllister TE, England KS, Hopkinson RJ, Brennan PE, Kawamura A, Schofield CJ.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/acs.jmedchem.5b01758

Bibliografisk träff 2016-01-06

Antitumor activity of LSD1 inhibitors in lung cancer.

Mohammad HP, Kruger RG.

Mol Cell Oncol · article-commentary; journal article · DOI 10.1080/23723556.2015.1117700

Bibliografisk träff 2015-07-01

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.

Mohammad HP, Smitheman KN, Kamat CD, Soong D, Federowicz KE, Van Aller GS, Schneck JL, Carson JD, Liu Y, Butticello M, Bonnette WG, Gorman SA, Degenhardt Y, Bai Y, McCabe MT, Pappalardi MB, Kasparec J, Tian X, McNulty KC, Rouse M, McDevitt P, Ho T, Crouthamel M, Hart TK, Concha NO, McHugh CF, Miller WH, Dhanak D, Tummino PJ, Carpenter CL, Johnson NW, Hann CL, Kruger RG.

Cancer Cell · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ccell.2015.06.002