Triphosphate Prodrugs of the Anti-HIV-Active Compound 3'-Deoxy-3'-fluorothymidine (FLT).
Weising S, Weber S, Schols D, Meier C.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.2c00665 PUBLICATION REGISTRY
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24 hitsAntitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
Macan AM, Harej A, Cazin I, Klobučar M, Stepanić V, Pavelić K, Pavelić SK, Schols D, Snoeck R, Andrei G, Raić-Malić S.
Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2019.111739Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
Pileggi E, Serpi M, Andrei G, Schols D, Snoeck R, Pertusati F.
Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.bmc.2018.05.034Synthesis and anti-HIV activities of unsymmetrical long chain dicarboxylate esters of dinucleoside reverse transcriptase inhibitors.
Agarwal HK, Chhikara BS, Doncel GF, Parang K.
Bioorg Med Chem Lett · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.bmcl.2017.03.031Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures.
Piotrowska DG, Andrei G, Schols D, Snoeck R, Łysakowska M.
Eur J Med Chem · research-article; journal article · DOI 10.1016/j.ejmech.2016.10.002First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via 'privileged scaffold' refining approach.
Kang D, Zhang H, Zhou Z, Huang B, Naesens L, Zhan P, Liu X.
Bioorg Med Chem Lett · brief-report; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.09.071Synthesis, anti-HIV and cytostatic evaluation of 3'-deoxy-3'-fluorothymidine (FLT) pro-nucleotides.
Velanguparackel W, Hamon N, Balzarini J, McGuigan C, Westwell AD.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2014.03.092Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors.
Agarwal HK, Buckheit KW, Buckheit RW, Parang K.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2012.07.037Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors.
Agarwal HK, Chhikara BS, Quiterio M, Doncel GF, Parang K.
J Med Chem · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm201551m3'-bromo analogues of pyrimidine nucleosides as a new class of potent inhibitors of Mycobacterium tuberculosis.
Shakya N, Srivastav NC, Desroches N, Agrawal B, Kunimoto DY, Kumar R.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm100165wSynthesis of fluorescent nucleoside analogs as probes for 2'-deoxyribonucleoside kinases.
Li Y, Soni PB, Liu L, Zhang X, Liotta DC, Lutz S.
Bioorg Med Chem Lett · comparative study; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2009.12.097[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].
Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.
Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.
Vanheusden V, Van Rompaey P, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00643-7Probing the mechanism of action and decomposition of amino acid phosphomonoester amidates of antiviral nucleoside prodrugs.
McIntee EJ, Remmel RP, Schinazi RF, Abraham TW, Wagner CR.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm960694fSynthesis and antiviral (HIV-1, HBV) activities of 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidine diastereomers. Potential prodrugs to 3'-fluoro-3'-deoxythymidine.
Kumar R, Wang L, Wiebe LI, Knaus EE.
J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00047a013HIV-1 reverse transcriptase inhibitor design using artificial neural networks.
Tetko IV, Tanchuk VYu, Chentsova NP, Antonenko SV, Poda GI, Kukhar VP, Luik AI.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00042a005Syntheses and biological evaluations of 3'-deoxy-3'-C-branched-chain-substituted nucleosides.
Lin TS, Zhu JL, Dutschman GE, Cheng YC, Prusoff WH.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00055a0063',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine.
Bergstrom DE, Mott AW, De Clercq E, Balzarini J, Swartling DJ.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00096a011Fluorinated sugar analogues of potential anti-HIV-1 nucleosides.
Huang JT, Chen LC, Wang LB, Kim MH, Warshaw JA, Armstrong D, Zhu QY, Chou TC, Watanabe KA, Matulic-Adamic J.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00109a0175'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity.
Jie L, Van Aerschot A, Balzarini J, Janssen G, Busson R, Hoogmartens J, De Clercq E, Herdewijn P.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00171a023Synthesis and antiviral activity of some 3'-C-difluoromethyl and 3'-deoxy-3'-C-fluoromethyl nucleosides.
Bamford MJ, Coe PL, Walker RT.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00171a0243'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues.
Van Aerschot A, Herdewijn P, Balzarini J, Pauwels R, De Clercq E.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00128a013Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.
Herdewijn P, Balzarini J, Baba M, Pauwels R, Van Aerschot A, Janssen G, De Clercq E.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00118a0333'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents.
Herdewijn P, Balzarini J, De Clercq E, Pauwels R, Baba M, Broder S, Vanderhaeghe H.
J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00391a003