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Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.

Publikationer som ChEBI hänvisar till för PF-06446846. Visa hela publikationsregistret

A publication hit is not a conclusion. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.

Publications in the selection

7 hits

Bibliografisk träff 2021-07-24

Evaluating Targeted Therapies in Ovarian Cancer Metabolism: Novel Role for PCSK9 and Second Generation mTOR Inhibitors.

Jacome Sanz D, Raivola J, Karvonen H, Arjama M, Barker H, Murumägi A, Ungureanu D.

Cancers (Basel) · research-article; journal article · DOI 10.3390/cancers13153727

Bibliografisk träff 2021-03-02

Synthesis of Moracin C and Its Derivatives with a 2-arylbenzofuran Motif and Evaluation of Their PCSK9 Inhibitory Effects in HepG2 Cells.

Masagalli JN, BasavanaGowda MK, Chae HS, Choi WJ.

Molecules · research-article; evaluation study; journal article · DOI 10.3390/molecules26051327

Bibliografisk träff 2020-10-02

Selective inhibition of human translation termination by a drug-like compound.

Li W, Chang ST, Ward FR, Cate JHD.

Nat Commun · research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41467-020-18765-2

Bibliografisk träff 2019-06-25

Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia.

Wu C, Xi C, Tong J, Zhao J, Jiang H, Wang J, Wang Y, Liu H.

Acta Pharm Sin B · research-article; journal article · DOI 10.1016/j.apsb.2019.06.006

Bibliografisk träff 2019-06-03

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.

Li W, Ward FR, McClure KF, Chang ST, Montabana E, Liras S, Dullea RG, Cate JHD.

Nat Struct Mol Biol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41594-019-0236-8

Bibliografisk träff 2018-06-25

Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.

Londregan AT, Wei L, Xiao J, Lintner NG, Petersen D, Dullea RG, McClure KF, Bolt MW, Warmus JS, Coffey SB, Limberakis C, Genovino J, Thuma BA, Hesp KD, Aspnes GE, Reidich B, Salatto CT, Chabot JR, Cate JHD, Liras S, Piotrowski DW.

J Med Chem · journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.8b00650

Bibliografisk träff 2017-03-21

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JH.

PLoS Biol · research-article; validation study; journal article · DOI 10.1371/journal.pbio.2001882