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Publikationer som ChEBI hänvisar till för XL413. Visa hela publikationsregistret

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Publications in the selection

10 hits

Bibliografisk träff 2021-07-15

Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach.

Pulakuntla S, Lokhande KB, Padmavathi P, Pal M, Swamy KV, Sadasivam J, Singh SA, Aramgam SL, Reddy VD.

Virusdisease · research-article; journal article · DOI 10.1007/s13337-021-00720-4

Bibliografisk träff 2020-06-09

Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.

Dick SD, Federico S, Hughes SM, Pye VE, O'Reilly N, Cherepanov P.

Structure · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.str.2020.05.010

Bibliografisk träff 2020-04-30

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair.

Wienert B, Nguyen DN, Guenther A, Feng SJ, Locke MN, Wyman SK, Shin J, Kazane KR, Gregory GL, Carter MAM, Wright F, Conklin BR, Marson A, Richardson CD, Corn JE.

Nat Commun · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41467-020-15845-1

Bibliografisk träff 2019-02-25

A High-Throughput Assay for DNA Replication Inhibitors Based upon Multivariate Analysis of Yeast Growth Kinetics.

Ngo M, Wechter N, Tsai E, Shun TY, Gough A, Schurdak ME, Schwacha A, Vogt A.

SLAS Discov · research-article; journal article; research support, n.i.h., extramural · DOI 10.1177/2472555219829740

Bibliografisk träff 2018-04-30

Cell division cycle 7 is a potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1.

Jin S, Ma H, Yang W, Ju H, Wang L, Zhang Z.

J Mol Med (Berl) · research support, non-u.s. gov't; journal article · DOI 10.1007/s00109-018-1636-7

Bibliografisk träff 2017-06-07

DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors.

Rainey MD, Quachthithu H, Gaboriau D, Santocanale C.

ACS Chem Biol · journal article · DOI 10.1021/acschembio.7b00117

Bibliografisk träff 2015-11-14

XL413, a cell division cycle 7 kinase inhibitor enhanced the anti-fibrotic effect of pirfenidone on TGF-β1-stimulated C3H10T1/2 cells via Smad2/4.

Jin SF, Ma HL, Liu ZL, Fu ST, Zhang CP, He Y.

Exp Cell Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.yexcr.2015.11.013

Bibliografisk träff 2014-11-20

The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.

Sasi NK, Tiwari K, Soon FF, Bonte D, Wang T, Melcher K, Xu HE, Weinreich M.

PLoS One · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1371/journal.pone.0113300

Bibliografisk träff 2012-10-14

Crystal structure of human CDC7 kinase in complex with its activator DBF4.

Hughes S, Elustondo F, Di Fonzo A, Leroux FG, Wong AC, Snijders AP, Matthews SJ, Cherepanov P.

Nat Struct Mol Biol · research support, non-u.s. gov't; journal article · DOI 10.1038/nsmb.2404

Bibliografisk träff 2012-04-16

Discovery of XL413, a potent and selective CDC7 inhibitor.

Koltun ES, Tsuhako AL, Brown DS, Aay N, Arcalas A, Chan V, Du H, Engst S, Ferguson K, Franzini M, Galan A, Holst CR, Huang P, Kane B, Kim MH, Li J, Markby D, Mohan M, Noson K, Plonowski A, Richards SJ, Robertson S, Shaw K, Stott G, Stout TJ, Young J, Yu P, Zaharia CA, Zhang W, Zhou P, Nuss JM, Xu W, Kearney PC.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2012.04.024