Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets.
Alles SRA, Smith PA.
Front Pain Res (Lausanne) · review-article; review; journal article · DOI 10.3389/fpain.2021.750583 PUBLICATION REGISTRY
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5 hitsMultiple-Ascending Dose Study in Healthy Subjects to Assess the Pharmacokinetics, Tolerability, and CYP3A4 Interaction Potential of the T-Type Calcium Channel Blocker ACT-709478, A Potential New Antiepileptic Drug.
Richard M, Kaufmann P, Ort M, Kornberger R, Dingemanse J.
CNS Drugs · research support, non-u.s. gov't; clinical trial, phase i; randomized controlled trial; journal article · DOI 10.1007/s40263-019-00697-1First-in-man study of ACT-709478, a novel selective triple T-type calcium channel blocker.
Richard M, Kaufmann P, Kornberger R, Dingemanse J.
Epilepsia · comparative study; research support, non-u.s. gov't; clinical trial, phase i; randomized controlled trial; journal article · DOI 10.1111/epi.14732T-type calcium channel blockers: a patent review (2012-2018).
Nam G.
Expert Opin Ther Pat · review; journal article · DOI 10.1080/13543776.2018.1541982Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
Bezençon O, Heidmann B, Siegrist R, Stamm S, Richard S, Pozzi D, Corminboeuf O, Roch C, Kessler M, Ertel EA, Reymond I, Pfeifer T, de Kanter R, Toeroek-Schafroth M, Moccia LG, Mawet J, Moon R, Rey M, Capeleto B, Fournier E.
J Med Chem · journal article · DOI 10.1021/acs.jmedchem.7b01236