NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs.
Celli CM, Tran N, Knox R, Jaiswal AK.
Biochem Pharmacol · journal article; research support, n.i.h., extramural · DOI 10.1016/j.bcp.2006.04.029 PUBLICATION REGISTRY
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25 hits7-N,7'-N'-(1",2"-Dithianyl-3",6"-dimethylenyl)bismitomycin C: synthesis and nucleophilic activation of a dimeric mitomycin.
Lee SH, Kohn H.
Org Biomol Chem · research support, u.s. gov't, p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1039/b414806aCyclic disulfide C8 iminoporfiromycin: nucleophilic activation of a porfiromycin.
Lee SH, Kohn H.
J Am Chem Soc · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/ja030577rPhase I and pharmacologic study of BMS-181174 given as a 6 h infusion every 4 weeks to patients with advanced solid tumors.
Planting AS, Schellens JH, van der Burg ME, de Boer-Dennert M, Winograd B, Stoter G, Verweij J.
Anticancer Drugs · clinical trial; clinical trial, phase i; journal article · DOI 10.1097/00001813-199910000-00005Studies on the mode of action of mitomycin C(7) aminoethylene disulfides (BMS-181174 and KW-2149): reactivity of 7-N-(mercaptoethyl)mitomycin C.
Wang S, Kohn H.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm9806796Phase I study of the mitomycin C analogue BMS-181174.
Macaulay VM, O'Byrne KJ, Green JA, Philip PA, McKinley L, LaCreta FP, Winograd B, Ganesan TS, Harris AL, Talbot DC.
Br J Cancer · clinical trial; research-article; clinical trial, phase i; journal article · DOI 10.1038/bjc.1998.336The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity.
Tomasz M, Palom Y.
Pharmacol Ther · review; journal article · DOI 10.1016/s0163-7258(97)00088-0Suppression of P-glycoprotein expression and multidrug resistance by DNA cross-linking agents.
Ihnat MA, Lariviere JP, Warren AJ, La Ronde N, Blaxall JR, Pierre KM, Turpie BW, Hamilton JW.
Clin Cancer Res · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal articleInvolvement of gene-specific DNA damage and apoptosis in the differential toxicity of mitomycin C analogs towards B-lineage versus T-lineage lymphoma cells.
Muscarella DE, Bloom SE.
Biochem Pharmacol · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/s0006-2952(97)00009-9Pharmacodynamic evaluation of mitomycin C analog BMS-181174 for potential use in intravesical bladder cancer therapy.
Yen WC, Au JL.
Pharm Res · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1023/a:1012069231506Characterization of a BMS-181174-resistant human bladder cancer cell line.
Xia H, Bleicher RJ, Hu X, Srivastava SK, Gupta V, Zaren HA, Singh SV.
Br J Cancer · research-article; journal article · DOI 10.1038/bjc.1997.410Lack of a role of glutathione in cellular nonenzymatic activation of BMS-181174, a novel analogue of mitomycin C.
Xia H, Pinto T, Hu X, Benson PJ, Zaren HA, Gupta V, Singh S.
Cancer Res · research support, u.s. gov't, p.h.s.; journal articleInteractions of BMS-181174 and radiation: studies with EMT6 cells in vitro and in solid tumors.
Rockwell S, Kelley M.
Radiother Oncol · research support, non-u.s. gov't; journal article · DOI 10.1016/0167-8140(95)01692-9Cytotoxicity of BMS-181174. Effects of hypoxia, dicoumarol, and repair deficits.
Rockwell S, Kemple B, Kelley M.
Biochem Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/0006-2952(95)00264-zCharacterization of a human bladder cancer cell line selected for resistance to BMY 25067, a novel analogue of mitomycin C.
Singh SV, Xu BH, Gupta V, Emerson EO, Zaren HA, Jani JP.
Cancer Lett · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1016/0304-3835(95)03864-sMechanism of differential sensitivity of human bladder cancer cells to mitomycin C and its analogue.
Xu BH, Gupta V, Singh SV.
Br J Cancer · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1038/bjc.1994.46Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY 25282 and BMY 25067, in isolated rat hepatocytes.
Silva JM, Khan S, O'Brien PJ.
Biochem Pharmacol · comparative study; journal article · DOI 10.1016/0006-2952(93)90203-9Effect of buthionine sulfoximine and ethacrynic acid on cytotoxic activity of mitomycin C analogues BMY 25282 and BMY 25067.
Xu BH, Singh SV.
Cancer Res · research support, u.s. gov't, p.h.s.; journal articleNovel chemotherapeutic agents in clinical development.
Erlichman C.
Curr Opin Oncol · review; journal article · DOI 10.1097/00001622-199112000-00011Second generation analogs of etoposide and mitomycin C.
Doyle TW, Vyas DM.
Cancer Treat Rev · review; journal article · DOI 10.1016/0305-7372(90)90036-fDNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues.
Dusre L, Rajagopalan S, Eliot HM, Covey JM, Sinha BK.
Cancer Res · journal articleAntitumor activity and toxicity in animals of N-7[2-(4-nitrophenyldithio) ethyl] mitomycin C (BMY-25067).
Bradner WT, Rose WC, Schurig JE, Florczyk AP.
Invest New Drugs · journal article · DOI 10.1007/bf00171978Free-radical formation by mitomycin C and its novel analogs in cardiac microsomes and the perfused rat heart.
Politi PM, Rajagopalan S, Sinha BK.
Biochim Biophys Acta · journal article · DOI 10.1016/0304-4165(89)90094-9Cardiac, renal, and pulmonary toxicity of several mitomycin derivatives in rats.
Bregman CL, Buroker RA, Bradner WT, Hirth RS, Madissoo H.
Fundam Appl Toxicol · journal article · DOI 10.1016/0272-0590(89)90306-0The search for more active and less toxic mitomycin and etoposide analogs.
Stringfellow DA, Schurig JE.
Cancer Treat Rev · journal article · DOI 10.1016/0305-7372(87)90020-x