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Publikationer som ChEBI hänvisar till för PABA/NO. Visa hela publikationsregistret

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Publications in the selection

15 hits

Bibliografisk träff 2015-05-19

PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells.

Kim Y, Maciag AE, Cao Z, Deschamps JR, Saavedra JE, Keefer LK, Holland RJ.

Bioorg Med Chem · research support, n.i.h., intramural; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2015.05.020

Bibliografisk träff 2013-05-16

Hybrid molecule from O2-(2,4-dinitrophenyl)diazeniumdiolate and oleanolic acid: a glutathione S-transferase π-activated nitric oxide prodrug with selective anti-human hepatocellular carcinoma activity and improved stability.

Fu J, Liu L, Huang Z, Lai Y, Ji H, Peng S, Tian J, Zhang Y.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm400393u

Bibliografisk träff 2012-05-13

S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor α Stability and Function.

Xiong Y, Manevich Y, Tew KD, Townsend DM.

Int J Cell Biol · research-article; journal article · DOI 10.1155/2012/273549

Bibliografisk träff 2011-07-21

Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas.

Kogias E, Osterberg N, Baumer B, Psarras N, Koentges C, Papazoglou A, Saavedra JE, Keefer LK, Weyerbrock A.

Int J Cancer · research-article; journal article; research support, n.i.h., extramural · DOI 10.1002/ijc.26106

Bibliografisk träff 2010-07-01

Broad-Spectrum Anti-Cancer Activity of O-Arylated Diazeniumdiolates.

Keefer LK, behalf of the JS-K Consortium.

For Immunopathol Dis Therap · research-article; journal article · DOI 10.1615/forumimmundisther.v1.i3.30

Bibliografisk träff 2010-03-16

Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO.

Hutchens S, Manevich Y, He L, Tew KD, Townsend DM.

Invest New Drugs · research-article; journal article; research support, n.i.h., extramural · DOI 10.1007/s10637-010-9407-5

Bibliografisk träff 2010-02-01

Stabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and Double JS-K, through incorporation into PEG-protected nanoparticles.

Kumar V, Hong SY, Maciag AE, Saavedra JE, Adamson DH, Prud'homme RK, Keefer LK, Chakrapani H.

Mol Pharm · research support, n.i.h., intramural; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/mp900245h

Bibliografisk träff 2009-09-22

Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.

Townsend DM, Manevich Y, He L, Xiong Y, Bowers RR, Hutchens S, Tew KD.

Cancer Res · research-article; journal article; research support, n.i.h., extramural · DOI 10.1158/0008-5472.can-09-0493

Bibliografisk träff 2008-12-01

Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities.

Andrei D, Maciag AE, Chakrapani H, Citro ML, Keefer LK, Saavedra JE.

J Med Chem · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800831y

Bibliografisk träff 2008-01-01

Structure-Based Design of Anticancer Prodrug PABA/NO.

Ji X, Pal A, Kalathur R, Kalathur R, Hu X, Gu Y, Saavedra JE, Buzard GS, Srinivasan A, Keefer LK, Singh SV.

Drug Des Devel Ther · research-article; journal article · DOI 10.2147/dddt.s3931

Bibliografisk träff 2007-11-17

Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound.

Chakrapani H, Wilde TC, Citro ML, Goodblatt MM, Keefer LK, Saavedra JE.

Bioorg Med Chem · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2007.11.035

Bibliografisk träff 2006-02-01

PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity.

Saavedra JE, Srinivasan A, Buzard GS, Davies KM, Waterhouse DJ, Inami K, Wilde TC, Citro ML, Cuellar M, Deschamps JR, Parrish D, Shami PJ, Findlay VJ, Townsend DM, Tew KD, Singh S, Jia L, Ji X, Keefer LK.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm050700k

Bibliografisk träff 2005-11-15

A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins.

Townsend DM, Findlay VJ, Fazilev F, Ogle M, Fraser J, Saavedra JE, Ji X, Keefer LK, Tew KD.

Mol Pharmacol · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/mol.105.018523

Bibliografisk träff 2005-01-01

Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets.

Townsend DM, Findlay VL, Tew KD.

Methods Enzymol · research-article; review; journal article · DOI 10.1016/s0076-6879(05)01019-0

Bibliografisk träff 2004-05-01

Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug.

Findlay VJ, Townsend DM, Saavedra JE, Buzard GS, Citro ML, Keefer LK, Ji X, Tew KD.

Mol Pharmacol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1124/mol.65.5.1070