Taurocholic acid promotes hepatic stellate cell activation via S1PR2/p38 MAPK/YAP signaling under cholestatic conditions.
Yang J, Tang X, Liang Z, Chen M, Sun L.
Clin Mol Hepatol · research-article; journal article · DOI 10.3350/cmh.2022.0327 PUBLICATION REGISTRY
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Publications in the selection
18 hitsInhibition of Sphingosine-1-Phosphate Receptor 2 by JTE013 Enhanced Alveolar Bone Regeneration by Promoting Angiogenesis.
Lory W, Wellslager B, Sun C, Yilmaz Ö, Yu H.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms24043401Opposing Roles of Sphingosine 1-Phosphate Receptors 1 and 2 in Fat Deposition and Glucose Tolerance in Obese Male Mice.
Asano M, Kajita K, Fuwa M, Kajita T, Mori I, Akahoshi N, Ishii I, Morita H.
Endocrinology · research support, non-u.s. gov't; research-article; journal article · DOI 10.1210/endocr/bqad019Design, synthesis, and evaluation of JTE-013 derivatives as novel potent S1PR2 antagonists for recovering the sensitivity of colorectal cancer to 5-fluorouracil.
Guo Z, Zhang S, Liu X, Zhao G, Zhang Y, Luo D, Zhao X, Xu X, Qu X, Li L, Wan S, Cui S.
Bioorg Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bioorg.2022.106318<i>Clonorchis sinensis</i> infection induces hepatobiliary injury <i>via</i> disturbing sphingolipid metabolism and activating sphingosine 1-phosphate receptor 2.
Liu JX, Liu M, Yu GZ, Zhao QQ, Wang JL, Sun YH, Koda S, Zhang B, Yu Q, Yan C, Tang RX, Jiang ZH, Zheng KY.
Front Cell Infect Microbiol · research support, non-u.s. gov't; research-article; journal article · DOI 10.3389/fcimb.2022.1011378The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism.
Pitman MR, Lewis AC, Davies LT, Moretti PAB, Anderson D, Creek DJ, Powell JA, Pitson SM.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41598-021-04009-wInhibition of Sphingosine-1-Phosphate Receptor 2 by JTE013 Promoted Osteogenesis by Increasing Vesicle Trafficking, Wnt/Ca<sup>2+</sup>, and BMP/Smad Signaling.
Lin S, Pandruvada S, Yu H.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms222112060Bivalirudin Attenuates Thrombin-Induced Endothelial Hyperpermeability via S1P/S1PR2 Category: Original Articles.
Ye H, Zhang Y, Huang Y, Li B, Cao R, Dai L, Huang B, Tian P, Li L, Han Y.
Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2021.721200JTE-013 Alleviates Inflammatory Injury and Endothelial Dysfunction Induced by Sepsis In Vivo and In Vitro.
Xu Q, Chen J, Zhu Y, Xia W, Liu Y, Xu J.
J Surg Res · journal article · DOI 10.1016/j.jss.2021.03.006S1PR2 Inhibition Attenuates Allergic Asthma Possibly by Regulating Autophagy.
Liu H, Li L, Chen Z, Song Y, Liu W, Gao G, Li L, Jiang J, Xu C, Yan G, Cui H.
Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2020.598007Topical Application of S1P<sub>2</sub> Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice.
Kang J, Lee JH, Im DS.
Biomol Ther (Seoul) · research-article; journal article · DOI 10.4062/biomolther.2020.036[Inhibitory Effect of S1PR2 Antagonist JTE-013 on Proliferation of Chronic Myeloid Leukemia Cells].
Pang M, Li F, Wang J, Jing HM.
Zhongguo Shi Yan Xue Ye Xue Za Zhi · journal article · DOI 10.19746/j.cnki.issn.1009-2137.2020.04.002S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer.
Zhang YH, Luo DD, Wan SB, Qu XJ.
Pharmacol Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.phrs.2020.104717JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.
Liu K, Cui K, Feng H, Li R, Lin H, Chen Y, Zhang Y, Chen Z, Yuan H, Li M, Wang T, Lan R, Liu J, Rao K, Wen B.
Andrology · research support, non-u.s. gov't; journal article · DOI 10.1111/andr.12716Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells.
Terashita T, Kobayashi K, Nagano T, Kawa Y, Tamura D, Nakata K, Yamamoto M, Tachihara M, Kamiryo H, Nishimura Y.
Respir Res · research-article; journal article · DOI 10.1186/s12931-016-0465-xTumor Necrosis Factor-induced Decrease of Cochlear Blood Flow Can Be Reversed by Etanercept or JTE-013.
Sharaf K, Ihler F, Bertlich M, Reichel CA, Berghaus A, Canis M.
Otol Neurotol · journal article · DOI 10.1097/mao.0000000000001095Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.
Li C, Chi XX, Xie W, Strong JA, Zhang JM, Nicol GD.
J Neurophysiol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1152/jn.00825.2011Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5.
Ikeda H, Satoh H, Yanase M, Inoue Y, Tomiya T, Arai M, Tejima K, Nagashima K, Maekawa H, Yahagi N, Yatomi Y, Sakurada S, Takuwa Y, Ogata I, Kimura S, Fujiwara K.
Gastroenterology · journal article · DOI 10.1053/gast.2003.50049