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Publikationer som ChEBI hänvisar till för b-AP15. Visa hela publikationsregistret

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Publications in the selection

33 hits

Bibliografisk träff 2023-11-20

MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14.

Li G, Zhou C, Wang L, Zheng Y, Zhou B, Li G, Ma Z, Sun P, Deng Y, Su L, Wang J, Cui H.

Pigment Cell Melanoma Res · research support, non-u.s. gov't; journal article · DOI 10.1111/pcmr.13150

Bibliografisk träff 2023-08-01

Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells.

Ding W, Wang JX, Wu JZ, Liu AC, Jiang LL, Zhang HC, Meng Y, Liu BY, Peng GJ, Lou EZ, Mao Q, Zhou H, Tang DL, Chen X, Liu JB, Shi XP.

Acta Pharmacol Sin · research-article; journal article · DOI 10.1038/s41401-023-01136-0

Bibliografisk träff 2023-05-26

An abundance of free regulatory (19<i>S</i>) proteasome particles regulates neuronal synapses.

Sun C, Desch K, Nassim-Assir B, Giandomenico SL, Nemcova P, Langer JD, Schuman EM.

Science · journal article · DOI 10.1126/science.adf2018

Bibliografisk träff 2023-04-13

Inhibition of USP14 promotes TNFα-induced cell death in head and neck squamous cell carcinoma (HNSCC).

Morgan EL, Toni T, Viswanathan R, Robbins Y, Yang X, Cheng H, Gunti S, Huynh A, Sowers AL, Mitchell JB, Allen CT, Chen Z, Van Waes C.

Cell Death Differ · research support, n.i.h., intramural; research-article; journal article · DOI 10.1038/s41418-023-01144-x

Bibliografisk träff 2022-11-01

Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).

Yang Y, Cao L, Guo Z, Gu H, Zhang K, Qiu Z.

Exp Cell Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.yexcr.2022.113402

Bibliografisk träff 2022-09-21

Proteasomal deubiquitylase activity enhances cell surface recycling of the epidermal growth factor receptor in non-small cell lung cancer.

Wang S, Wang T, Yang Q, Cheng S, Liu F, Yang G, Wang F, Wang R, Yang D, Zhou M, Duan C, Zhang Y, Liu H, Dai Z, Tian K, Liu S.

Cell Oncol (Dordr) · research-article; journal article · DOI 10.1007/s13402-022-00699-0

Bibliografisk träff 2022-09-01

Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia.

Jiang L, He Q, Chen X, Liu A, Ding W, Zhang H, Chen X, Zhou H, Meng Y, Liu B, Peng G, Wang C, Liu J, Shi X.

Clin Transl Med · research-article; journal article · DOI 10.1002/ctm2.1038

Bibliografisk träff 2022-08-05

The UCHL5 inhibitor b-AP15 overcomes cisplatin resistance via suppression of cancer stemness in urothelial carcinoma.

Chow PM, Dong JR, Chang YW, Kuo KL, Lin WC, Liu SH, Huang KH.

Mol Ther Oncolytics · research-article; journal article · DOI 10.1016/j.omto.2022.08.004

Bibliografisk träff 2022-06-01

Inhibition of USP14 enhances anti-tumor effect in vemurafenib-resistant melanoma by regulation of Skp2.

Wu T, Li C, Zhou C, Niu X, Li G, Zhou Y, Gu X, Cui H.

Cell Biol Toxicol · research support, non-u.s. gov't; journal article · DOI 10.1007/s10565-022-09729-x

Bibliografisk träff 2022-04-27

A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37.

van der Wal L, Bezstarosti K, Demmers JAA.

J Proteomics · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jprot.2022.104592

Bibliografisk träff 2022-04-22

Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action.

Gubat J, Selvaraju K, Sjöstrand L, Kumar Singh D, Turkina MV, Schmierer B, Sabatier P, Zubarev RA, Linder S, D'Arcy P.

Front Oncol · research-article; journal article · DOI 10.3389/fonc.2022.852980

Bibliografisk träff 2022-01-01

Treatment with b-AP15 to Inhibit UCHL5 and USP14 Deubiquitinating Activity and Enhance p27 and Cyclin E1 for Tumors with <i>p53</i> Deficiency.

Jiang ZY, Hong J, Zhang JH, Wang XF, Ma YS, Xiong ZX, Sun HR, Cheng C, Xie BZ, Liu JB, Ouyang YG, Fu D.

Technol Cancer Res Treat · research support, non-u.s. gov't; research-article; journal article · DOI 10.1177/15330338221119745

Bibliografisk träff 2021-11-25

Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.

Ming SL, Zhang S, Wang Q, Zeng L, Zhou LY, Wang MD, Ma YX, Han LQ, Zhong K, Zhu HS, Bai YL, Yang GY, Wang J, Chu BB.

Autophagy · research support, non-u.s. gov't; research-article; journal article · DOI 10.1080/15548627.2021.2002101

Bibliografisk träff 2020-11-04

Dienone Compounds: Targets and Pharmacological Responses.

Bazzaro M, Linder S.

J Med Chem · research support, non-u.s. gov't; review-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c00812

Bibliografisk träff 2020-04-22

Deubiquitinase Inhibitor b-AP15 Attenuated LPS-Induced Inflammation via Inhibiting ERK1/2, JNK, and NF-Kappa B.

Zhang F, Xu R, Chai R, Xu Q, Liu M, Chen X, Chen X, Kong T, Zhang C, Liu SM, Zhang Z, Liu N.

Front Mol Biosci · research-article; journal article · DOI 10.3389/fmolb.2020.00049

Bibliografisk träff 2020-04-01

Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency.

Ma YS, Wang XF, Yu F, Wu TM, Liu JB, Zhang YJ, Xia Q, Jiang ZY, Lin QL, Fu D.

Signal Transduct Target Ther · letter; research support, non-u.s. gov't · DOI 10.1038/s41392-020-0143-9

Bibliografisk träff 2020-03-19

Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs.

Ward JA, Pinto-Fernandez A, Cornelissen L, Bonham S, Díaz-Sáez L, Riant O, Huber KVM, Kessler BM, Feron O, Tate EW.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.0c00144

Bibliografisk träff 2019-11-06

Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma.

Jiang L, Sun Y, Wang J, He Q, Chen X, Lan X, Chen J, Dou QP, Shi X, Liu J.

J Exp Clin Cancer Res · research-article; journal article · DOI 10.1186/s13046-019-1446-y

Bibliografisk träff 2019-10-22

Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15.

Mofers A, Perego P, Selvaraju K, Gatti L, Gullbo J, Linder S, D'Arcy P.

PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0223807

Bibliografisk träff 2019-10-01

Deubiquitylatinase inhibitor b-AP15 induces c-Myc-Noxa-mediated apoptosis in esophageal squamous cell carcinoma.

Sha B, Chen X, Wu H, Li M, Shi J, Wang L, Liu X, Chen P, Hu T, Li P.

Apoptosis · research support, non-u.s. gov't; journal article · DOI 10.1007/s10495-019-01561-9

Bibliografisk träff 2019-06-10

Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment.

Zhang X, Espinosa B, Saei AA, D'Arcy P, Zubarev RA, Linder S.

Oxid Med Cell Longev · research-article; journal article · DOI 10.1155/2019/1659468

Bibliografisk träff 2019-05-25

The Deubiquitinase Inhibitor b-AP15 and Its Effect on Phenotype and Function of Monocyte-Derived Dendritic Cells.

Schmidt M, Altdörfer V, Schnitte S, Fuchs AR, Kropp KN, Maurer S, Müller MR, Salih HR, Rittig SM, Grünebach F, Dörfel D.

Neoplasia · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.neo.2019.03.001

Bibliografisk träff 2019-02-13

Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.

Hillert EK, Brnjic S, Zhang X, Mazurkiewicz M, Saei AA, Mofers A, Selvaraju K, Zubarev R, Linder S, D'Arcy P.

Cancer Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.canlet.2019.02.003

Bibliografisk träff 2018-08-25

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage.

Zhang X, Pellegrini P, Saei AA, Hillert EK, Mazurkiewicz M, Olofsson MH, Zubarev RA, D'Arcy P, Linder S.

Biochem Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bcp.2018.08.039

Bibliografisk träff 2018-03-19

The novel deubiquitinase inhibitor b-AP15 induces direct and NK cell-mediated antitumor effects in human mantle cell lymphoma.

Kropp KN, Maurer S, Rothfelder K, Schmied BJ, Clar KL, Schmidt M, Strunz B, Kopp HG, Steinle A, Grünebach F, Rittig SM, Salih HR, Dörfel D.

Cancer Immunol Immunother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1007/s00262-018-2151-y

Bibliografisk träff 2018-02-15

Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells.

Ding Y, Chen X, Wang B, Yu B, Ge J.

Eur J Pharmacol · journal article · DOI 10.1016/j.ejphar.2018.02.020

Bibliografisk träff 2017-08-14

The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5.

Oh YT, Deng L, Deng J, Sun SY.

Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41598-017-08424-w

Bibliografisk träff 2017-06-28

A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers.

Cai J, Xia X, Liao Y, Liu N, Guo Z, Chen J, Yang L, Long H, Yang Q, Zhang X, Xiao L, Wang X, Huang H, Liu J.

Oncotarget · research-article; journal article · DOI 10.18632/oncotarget.18774

Bibliografisk träff 2015-05-27

Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15.

Wang X, D'Arcy P, Caulfield TR, Paulus A, Chitta K, Mohanty C, Gullbo J, Chanan-Khan A, Linder S.

Chem Biol Drug Des · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1111/cbdd.12571

Bibliografisk träff 2014-10-14

Inhibitory effect of b-AP15 on the 20S proteasome.

Huang L, Jung K, Chen CH.

Biomolecules · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.3390/biom4040931