Role of p53 in Cisplatin-Induced Myotube Atrophy.
Matsumoto C, Sekine H, Zhang N, Mogami S, Fujitsuka N, Takeda H.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms24119176 PUBLICATION REGISTRY
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28 hitsThe p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.
Hsieh YH, Chao AC, Lin YC, Chen SD, Yang DI.
Free Radic Biol Med · research support, non-u.s. gov't; journal article · DOI 10.1016/j.freeradbiomed.2021.04.004Pifithrin-Alpha Reduces Methamphetamine Neurotoxicity in Cultured Dopaminergic Neurons.
Chen YH, Bae E, Chen H, Yu SJ, Harvey BK, Greig NH, Wang Y.
Neurotox Res · research-article; journal article · DOI 10.1007/s12640-019-00050-wAberrant Caspase Activation in Laminin-α2-Deficient Human Myogenic Cells is Mediated by p53 and Sirtuin Activity.
Yoon S, Beermann ML, Yu B, Shao D, Bachschmid M, Miller JB.
J Neuromuscul Dis · research-article; journal article · DOI 10.3233/jnd-170262Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells.
Kanno S, Kurauchi K, Tomizawa A, Yomogida S, Ishikawa M.
Toxicol Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.toxlet.2014.11.016[Roles of p53 in the interaction of p21 and cell cycle proteins induced by benzo [a] pyrene].
Zhang X, Li Y, Jia X, Liu B, Ye M.
Wei Sheng Yan Jiu · journal articleA putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor.
Fetoni AR, Fetoni AR, Bielefeld EC, Paludetti G, Nicotera T, Henderson D.
Neurosci Res · journal article; research support, n.i.h., extramural · DOI 10.1016/j.neures.2014.01.006Effect of p53 inhibition by pifithrin-alpha on functional activity of vasopressin neurones in rat hypothalamus.
Dorofeeva NA, Chernigovskaya EV, Nikitina LS, Glazova M.
Ross Fiziol Zh Im I M Sechenova · research support, non-u.s. gov't; journal articleRelation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-alpha, an inhibitor of p53.
Meschini R, Berni A, Ortenzi V, Mancinelli P, Palitti F.
Mutat Res · journal article · DOI 10.1016/j.mrgentox.2010.03.017p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms.
Wang Y, Dong XX, Cao Y, Liang ZQ, Han R, Wu JC, Gu ZL, Qin ZH.
Eur J Neurosci · research support, non-u.s. gov't; journal article · DOI 10.1111/j.1460-9568.2009.07025.xPFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells.
Misra UK, Pizzo SV.
Biochem Biophys Res Commun · journal article · DOI 10.1016/j.bbrc.2009.11.048Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells.
Singh PK, Kumar R, Sharma A, Arora R, Jain SK, Sharma RK.
Biotechnol Appl Biochem · research support, non-u.s. gov't; journal article · DOI 10.1042/ba20080250Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53.
Sohn D, Graupner V, Neise D, Essmann F, Schulze-Osthoff K, Jänicke RU.
Cell Death Differ · research support, non-u.s. gov't; journal article · DOI 10.1038/cdd.2009.17Possible involvement of NO in the stimulating effect of pifithrins on survival of hemopoietic clonogenic cells.
Proskuryakov SY, Konoplyannikov AG, Konoplyannikova OA, Shevchenko LI, Verkhovskii YG, Tsyb AF.
Biochemistry (Mosc) · research support, non-u.s. gov't; journal article · DOI 10.1134/s0006297909020023Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion.
Liu P, Xu B, Cavalieri TA, Hock CE.
Shock · journal article · DOI 10.1097/shk.0b013e31816a192dPifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat.
Yan JH, Yang XM, Chen CH, Hu Q, Zhao J, Shi XZ, Luan LJ, Yang L, Qin LH, Zhou CM.
Chin Med J (Engl) · research support, non-u.s. gov't; journal articleInhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos.
Davidson W, Ren Q, Kari G, Kashi O, Dicker AP, Rodeck U.
Cell Cycle · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.4161/cc.7.9.5786MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells.
Wu SJ, Ng LT.
Food Chem Toxicol · journal article · DOI 10.1016/j.fct.2007.05.032Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils.
Gupta S, Gupta YK, Sharma SS.
Indian J Physiol Pharmacol · research support, non-u.s. gov't; journal articleMultiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells.
Chua CC, Liu X, Gao J, Hamdy RC, Chua BH.
Am J Physiol Heart Circ Physiol · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1152/ajpheart.01138.2005Effects of intracellular calcium chelation and pifithrin-alpha on deoxynucleotide metabolism in human lymphocytes.
Spasokoukotskaja T, Csapó Z, Virga S, Sasvári-Székely M, Staub M, Keszler G.
Nucleosides Nucleotides Nucleic Acids · research support, non-u.s. gov't; journal article · DOI 10.1080/15257770600894402Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha.
Sparfel L, Van Grevenynghe J, Le Vee M, Aninat C, Fardel O.
Carcinogenesis · research support, non-u.s. gov't; journal article · DOI 10.1093/carcin/bgi256The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor.
Hoagland MS, Hoagland EM, Swanson HI.
J Pharmacol Exp Ther · research support, u.s. gov't, p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1124/jpet.105.084186Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis.
El-Gibaly AM, Scheuer C, Menger MD, Vollmar B.
Hepatology · research support, non-u.s. gov't; journal article · DOI 10.1002/hep.20243Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice.
Liu X, Chua CC, Gao J, Chen Z, Landy CL, Hamdy R, Chua BH.
Am J Physiol Heart Circ Physiol · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1152/ajpheart.00759.2003Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells.
Kaji A, Zhang Y, Nomura M, Bode AM, Ma WY, She QB, Dong Z.
Mol Carcinog · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1002/mc.10130Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium.
Begum RA, Farah IO, Ishaque AB.
Biomed Sci Instrum · journal articleA chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV, Gudkov AV.
Science · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1126/science.285.5434.1733