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Publikationer som ChEBI hänvisar till för GDC-0326. Visa hela publikationsregistret

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Publications in the selection

6 hits

Bibliografisk träff 2023-08-26

Quantum biochemistry description of PI3Kα enzyme bound to selective inhibitors.

Freitas de Sousa FJ, Nunes Azevedo FF, Santos de Oliveira FL, Vieira Carletti J, Freire VN, Zanatta G.

J Biomol Struct Dyn · research support, non-u.s. gov't; journal article · DOI 10.1080/07391102.2023.2251063

Bibliografisk träff 2022-03-23

Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling.

Lange M, Ohnesorge N, Hoffmann D, Rocha SF, Benedito R, Siekmann AF.

Dev Biol · research-article; journal article · DOI 10.1016/j.ydbio.2022.03.006

Bibliografisk träff 2022-01-29

Challenges in the structure determination of a dimeric impurity found during development of GDC-0326.

Segraves NL, Koenig SG, Stults J, Ma S, DiPasquale AG, Robinson SJ, Russell DJ.

J Pharm Biomed Anal · journal article · DOI 10.1016/j.jpba.2022.114627

Bibliografisk träff 2021-04-13

GDC-0326 Enhances the Effects of 5-Fu in Colorectal Cancer Cells by Inducing Necroptotic Death.

Zhang Z, Ju F, Chen F, Wu H, Chen J, Zhong J, Shao L, Zheng S, Wang L, Xue M.

Onco Targets Ther · research-article; journal article · DOI 10.2147/ott.s302334

Bibliografisk träff 2016-05-25

Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors.

Soler A, Figueiredo AM, Castel P, Martin L, Monelli E, Angulo-Urarte A, Milà-Guasch M, Viñals F, Baselga J, Casanovas O, Graupera M.

Clin Cancer Res · research-article; journal article · DOI 10.1158/1078-0432.ccr-15-3051

Bibliografisk träff 2016-01-20

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

Heffron TP, Heald RA, Ndubaku C, Wei B, Augistin M, Do S, Edgar K, Eigenbrot C, Friedman L, Gancia E, Jackson PS, Jones G, Kolesnikov A, Lee LB, Lesnick JD, Lewis C, McLean N, Mörtl M, Nonomiya J, Pang J, Price S, Prior WW, Salphati L, Sideris S, Staben ST, Steinbacher S, Tsui V, Wallin J, Sampath D, Olivero AG.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.5b01483