VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors.
Xiao Z, Li S, Yu Y, Li M, Chen J, Wang F, Zhang J, Deng W, Yang Q, Fan X.
Mol Cell Biochem · journal article · DOI 10.1007/s11010-018-3337-5 PUBLICATION REGISTRY
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12 hitsTargeting the C-MET/HGF Signaling Pathway in Pancreatic Ductal Adenocarcinoma.
Ghanaatgar-Kasbi S, Khorrami S, Avan A, Aledavoud SA, Ferns GA.
Curr Pharm Des · research support, non-u.s. gov't; review; journal article · DOI 10.2174/1381612825666190110145855MK2461, a Multitargeted Kinase Inhibitor, Suppresses the Progression of Pancreatic Cancer by Disrupting the Interaction Between Pancreatic Cancer Cells and Stellate Cells.
Inoue K, Ohtsuka H, Tachikawa M, Motoi F, Shijo M, Douchi D, Kawasaki S, Kawaguchi K, Masuda K, Fukase K, Naitoh T, Katayose Y, Egawa S, Unno M, Terasaki T.
Pancreas · research support, non-u.s. gov't; journal article · DOI 10.1097/mpa.0000000000000778Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors.
Klaeger S, Gohlke B, Perrin J, Gupta V, Heinzlmeir S, Helm D, Qiao H, Bergamini G, Handa H, Savitski MM, Bantscheff M, Médard G, Preissner R, Kuster B.
ACS Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1021/acschembio.5b01063Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461.
Wu JF, Liu MM, Huang SX, Wang Y.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2015.05.082MET inhibitors in combination with other therapies in non-small cell lung cancer.
Padda S, Neal JW, Wakelee HA.
Transl Lung Cancer Res · review-article; review; journal article · DOI 10.3978/j.issn.2218-6751.2012.10.08Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
Katz JD, Jewell JP, Guerin DJ, Lim J, Dinsmore CJ, Deshmukh SV, Pan BS, Marshall CG, Lu W, Altman MD, Dahlberg WK, Davis L, Falcone D, Gabarda AE, Hang G, Hatch H, Holmes R, Kunii K, Lumb KJ, Lutterbach B, Mathvink R, Nazef N, Patel SB, Qu X, Reilly JF, Rickert KW, Rosenstein C, Soisson SM, Spencer KB, Szewczak AA, Walker D, Wang W, Young J, Zeng Q.
J Med Chem · journal article · DOI 10.1021/jm200112kDiscovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
Shallal HM, Russu WA.
Eur J Med Chem · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2011.02.057Structural basis for selective small molecule kinase inhibition of activated c-Met.
Rickert KW, Patel SB, Allison TJ, Byrne NJ, Darke PL, Ford RE, Guerin DJ, Hall DL, Kornienko M, Lu J, Munshi SK, Reid JC, Shipman JM, Stanton EF, Wilson KJ, Young JR, Soisson SM, Lumb KJ.
J Biol Chem · research-article; journal article · DOI 10.1074/jbc.m110.204404Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics.
Katoh M.
Expert Rev Anticancer Ther · comment; journal article · DOI 10.1586/era.10.128MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.
Pan BS, Chan GK, Chenard M, Chi A, Davis LJ, Deshmukh SV, Gibbs JB, Gil S, Hang G, Hatch H, Jewell JP, Kariv I, Katz JD, Kunii K, Lu W, Lutterbach BA, Paweletz CP, Qu X, Reilly JF, Szewczak AA, Zeng Q, Kohl NE, Dinsmore CJ.
Cancer Res · journal article · DOI 10.1158/0008-5472.can-09-2541Gateways to clinical trials.
Tomillero A, Moral MA.
Methods Find Exp Clin Pharmacol · bibliography; journal article