3-AP inhibits the growth of human osteosarcoma by decreasing the activity of the iron-dependent pathway.
Huang S, Zhang D, Yi X, Liu C, Jian C, Yu A.
Med Oncol · journal article · DOI 10.1007/s12032-023-02215-2 PUBLICATION REGISTRY
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Publikationer som ChEBI hänvisar till för triapine. Visa hela publikationsregistret
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Publications in the selection
30 hitsInhibition of RRM2 radiosensitizes glioblastoma and uncovers synthetic lethality in combination with targeting CHK1.
Corrales-Guerrero S, Cui T, Castro-Aceituno V, Yang L, Nair S, Feng H, Venere M, Yoon S, DeWees T, Shen C, Williams TM.
Cancer Lett · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.canlet.2023.216308Co-delivery of gemcitabine and Triapine by calcium carbonate nanoparticles against chemoresistant pancreatic cancer.
Zhao Y, Zheng Y, Zhu Y, Ding K, Zhou M, Liu T.
Int J Pharm · journal article · DOI 10.1016/j.ijpharm.2023.122844Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes.
Ritacca AG, Falcone E, Doumi I, Vileno B, Faller P, Sicilia E.
Inorg Chem · research-article; journal article · DOI 10.1021/acs.inorgchem.2c04392Inhibition of Ribonucleotide Reductase Induces Endoplasmic Reticulum Stress and Apoptosis, Leading to the Death of Docetaxel-resistant Prostate Cancer Cells.
Serttas R, Erdogan S.
Anticancer Agents Med Chem · research support, non-u.s. gov't; journal article · DOI 10.2174/1871520623666230810094635Replication stress induced by the ribonucleotide reductase inhibitor guanazole, triapine and gemcitabine in fission yeast.
Alyahya MY, Khan S, Bhadra S, Samuel RE, Xu YJ.
FEMS Yeast Res · research-article; journal article; research support, n.i.h., extramural · DOI 10.1093/femsyr/foac014<i>E. coli</i> Ribonucleotide Reductase β2 Subunit Inactivation by Triapine Occurs through Binding of a Triapine-Fe(II) Adduct.
Safiarian MS, Watson RA, Lieberman RL, Barry BA, Offenbacher AR.
J Phys Chem Lett · journal article · DOI 10.1021/acs.jpclett.1c02103Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation.
Enyedy ÉA, May NV, Pape VFS, Heffeter P, Szakács G, Keppler BK, Kowol CR.
Dalton Trans · comparative study; journal article · DOI 10.1039/d0dt03465gIn vitro evaluation of the metabolic enzymes and drug interaction potential of triapine.
Joshi A, Kiesel BF, Chaphekar N, Jones R, Guo J, Kunos CA, Taylor S, Chu E, Venkataramanan R, Beumer JH.
Cancer Chemother Pharmacol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1007/s00280-020-04154-5Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells.
Ohui K, Stepanenko I, Besleaga I, Babak MV, Stafi R, Darvasiova D, Giester G, Pósa V, Enyedy EA, Vegh D, Rapta P, Ang WH, Popović-Bijelić A, Arion VB.
Biomolecules · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/biom10091336Ribonucleotide Reductase Inhibitor 3-AP Induces Oncogenic Virus Infected Cell Death and Represses Tumor Growth.
Dai L, Chen J, Cao Y, Del Valle L, Qin Z.
J Cancer · research-article; journal article · DOI 10.7150/jca.27437PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats.
Jiang ZG, Winocur G, Wojtowicz JM, Shevtsova O, Fuller S, Ghanbari HA.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0191866LC-MS/MS assay for the quantitation of the ribonucleotide reductase inhibitor triapine in human plasma.
Matsumoto J, Kiesel BF, Parise RA, Guo J, Taylor S, Huang M, Eiseman JL, Ivy SP, Kunos C, Chu E, Beumer JH.
J Pharm Biomed Anal · research-article; journal article · DOI 10.1016/j.jpba.2017.08.036PAN-811 Blocks Chemotherapy Drug-Induced In Vitro Neurotoxicity, While Not Affecting Suppression of Cancer Cell Growth.
Jiang ZG, Fuller SA, Ghanbari HA.
Oxid Med Cell Longev · research-article; journal article · DOI 10.1155/2016/9392404Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers.
Kunos CA, Radivoyevitch T, Waggoner S, Debernardo R, Zanotti K, Resnick K, Fusco N, Adams R, Redline R, Faulhaber P, Dowlati A.
Gynecol Oncol · clinical trial, phase ii; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ygyno.2013.04.019Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia.
Kunos CA, Radivoyevitch T, Ingalls ST, Hoppel CL.
Future Oncol · research-article; review; journal article · DOI 10.2217/fon.11.147A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced-stage solid cancers: a California Cancer Consortium Study.
Chao J, Synold TW, Morgan RJ, Kunos C, Longmate J, Lenz HJ, Lim D, Shibata S, Chung V, Stoller RG, Belani CP, Gandara DR, McNamara M, Gitlitz BJ, Lau DH, Ramalingam SS, Davies A, Espinoza-Delgado I, Newman EM, Yen Y.
Cancer Chemother Pharmacol · research support, non-u.s. gov't; research-article; clinical trial, phase i; journal article; research support, n.i.h., extramural · DOI 10.1007/s00280-011-1779-5Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.
Popović-Bijelić A, Kowol CR, Lind ME, Luo J, Himo F, Enyedy EA, Arion VB, Gräslund A.
J Inorg Biochem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1016/j.jinorgbio.2011.07.003Cytotoxic Evaluation of 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone, 3-AP, in Peripheral Blood Lymphocytes of Patients with Refractory Solid Tumors using Electron Paramagnetic Resonance.
Kolesar JM, Sachidanandam K, Schelman WR, Eickhoff J, Holen KD, Traynor AM, Alberti DB, Thomas JP, Chitambar CR, Wilding G, Antholine WE.
Exp Ther Med · research-article; journal article · DOI 10.3892/etm.2010.165Population pharmacokinetics of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine®) in cancer patients.
Kolesar J, Brundage RC, Pomplun M, Alberti D, Holen K, Traynor A, Ivy P, Wilding G.
Cancer Chemother Pharmacol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1007/s00280-010-1331-zPhase I trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer.
Kunos CA, Waggoner S, von Gruenigen V, Eldermire E, Pink J, Dowlati A, Kinsella TJ.
Clin Cancer Res · research-article; clinical trial, phase i; journal article; research support, n.i.h., extramural · DOI 10.1158/1078-0432.ccr-09-2469The maximum tolerated dose and biologic effects of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) in combination with irinotecan for patients with refractory solid tumors.
Choi BS, Alberti DB, Schelman WR, Kolesar JM, Thomas JP, Marnocha R, Eickhoff JC, Ivy SP, Wilding G, Holen KD.
Cancer Chemother Pharmacol · research support, non-u.s. gov't; research-article; clinical trial, phase i; journal article; research support, n.i.h., extramural · DOI 10.1007/s00280-010-1250-zFluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex.
Kowol CR, Trondl R, Arion VB, Jakupec MA, Lichtscheidl I, Keppler BK.
Dalton Trans · research support, non-u.s. gov't; journal article · DOI 10.1039/b919119bImpact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation.
Kowol CR, Trondl R, Heffeter P, Arion VB, Jakupec MA, Roller A, Galanski MS, Berger W, Keppler BK.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm900528dA phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas.
Attia S, Kolesar J, Mahoney MR, Pitot HC, Laheru D, Heun J, Huang W, Eickhoff J, Erlichman C, Holen KD.
Invest New Drugs · clinical trial, phase ii; research-article; multicenter study; journal article; research support, n.i.h., extramural · DOI 10.1007/s10637-008-9123-6In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone).
Barker CA, Burgan WE, Carter DJ, Cerna D, Gius D, Hollingshead MG, Camphausen K, Tofilon PJ.
Clin Cancer Res · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1158/1078-0432.ccr-05-2860Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) induces apoptosis in ovarian cancer cells.
Alvero AB, Chen W, Sartorelli AC, Schwartz P, Rutherford T, Mor G.
J Soc Gynecol Investig · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jsgi.2005.11.004Neuroprotective activity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (PAN-811), a cancer therapeutic agent.
Jiang ZG, Lebowitz MS, Ghanbari HA.
CNS Drug Rev · research support, non-u.s. gov't; research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1111/j.1527-3458.2006.00077.xPAN-811 (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), a novel neuroprotectant, elicits its function in primary neuronal cultures by up-regulating Bcl-2 expression.
Chen RW, Yao C, Lu XC, Jiang ZG, Whipple R, Liao Z, Ghanbari HA, Almassian B, Tortella FC, Dave JR.
Neuroscience · journal article · DOI 10.1016/j.neuroscience.2005.02.002Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Liu MC, Lin TS, Sartorelli AC.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00098a012