Tirbanibulin
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30 hitsTirbanibulin (KX2-391) analog KX2-361 inhibits botulinum neurotoxin serotype A mediated SNAP-25 cleavage in pre- and post-intoxication models in cells.
Koc D, Ibis K, Besarat P, Banoglu E, Kiris E.
Drug Dev Res · research support, non-u.s. gov't; journal article · DOI 10.1002/ddr.22248Topical tirbanibulin ointment 1% as a potential new treatment for recalcitrant plantar warts: a case report.
Iacomino G, Licata G, Tancredi V, Damiani L, Pellegrino V, Argenziano G, Giorgio CM.
Int J Dermatol · letter · DOI 10.1111/ijd.17436Tirbanibulin decreases cell proliferation and downregulates protein expression of oncogenic pathways in human papillomavirus containing HeLa cells.
Moore S, Kulkarni V, Moore A, Landes JR, Simonette R, He Q, Rady PL, Tyring SK.
Arch Dermatol Res · journal article · DOI 10.1007/s00403-024-03205-8Topical Pharmacological Treatment of Actinic Keratoses: Focus on Tirbanibulin 1% Ointment.
Valenti M, Bianco M, Narcisi A, Costanzo A, Borroni R, Ardigò M.
Dermatol Pract Concept · review-article; review; journal article · DOI 10.5826/dpc.1403s1a145sTirbanibulin ointment: A new effective and safe treatment of recalcitrant viral warts.
Mansilla-Polo M, Abril-Pérez C, Martín-Torregrosa D.
Semergen · letter · DOI 10.1016/j.semerg.2024.102278Anti-tumor effects of tirbanibulin in squamous cell carcinoma cells are mediated via disruption of tubulin-polymerization.
DeTemple VK, Walter A, Bredemeier S, Gutzmer R, Schaper-Gerhardt K.
Arch Dermatol Res · research-article; journal article · DOI 10.1007/s00403-024-03032-xReflectance confocal microscopy as noninvasive tool for monitoring tirbanibulin efficacy in actinic keratosis.
Venturi F, Veronesi G, Baraldi C, Dika E.
Photodiagnosis Photodyn Ther · journal article · DOI 10.1016/j.pdpdt.2024.104235Anti-aging Effects of Tirbanibulin 1% Ointment: A Real-Life Experience.
Li Pomi F, Peterle L, d'Aloja A, Di Tano A, Vaccaro M, Borgia F.
Dermatol Ther (Heidelb) · journal article · DOI 10.1007/s13555-024-01178-0Patient-and Clinician-Reported Outcomes for Tirbanibulin in Actinic Keratosis in Clinical Practice Across the United States (PROAK)
Schlesinger T, Kircik L, Lebwohl M, Patel VA, Berman B, Bhatia N, Rigel D, Armstrong A, Rosso JD, Narayanan S, Koscielny V, Kasujee I.
J Drugs Dermatol · multicenter study; journal article · DOI 10.36849/jdd.8264Efficacy and tolerability of tirbanibulin 1% ointment in the treatment of cancerization field: a real-life Italian multicenter observational study of 250 patients.
Nazzaro G, Carugno A, Bortoluzzi P, Buffon S, Astrua C, Zappia E, Trovato E, Caccavale S, Pellegrino V, Paolino G, Balestri R, Lacava R, Ciccarese G, Verdelli A, Barruscotti S, Valenti M, Toni G, Giacalone S, Zavattaro E, Gironi LC, Mercuri SR, Ribero S, Gisondi P, Sena P, Marzano AV.
Int J Dermatol · multicenter study; journal article; observational study · DOI 10.1111/ijd.17168Development of a Stability Indicating UPLC Method for the Determination of Tirbanibulin in Bulk and Its Pharmaceutical Dosage Form.
Gaddey PK, Sundararajan R.
Turk J Pharm Sci · research-article; journal article · DOI 10.4274/tjps.galenos.2023.18124Tirbanibulin and solar lentigo clearance: an aesthetically pleasing side effect?
Fidanzi C, Bevilacqua M, Salvia G, Romanelli M, Janowska A.
Int J Dermatol · letter · DOI 10.1111/ijd.17054Tirbanibulin 1% Ointment for Actinic Keratosis: Results from a Real-Life Study.
Li Pomi F, Vaccaro M, Pallio G, Rottura M, Irrera N, Borgia F.
Medicina (Kaunas) · research-article; journal article · DOI 10.3390/medicina60020225Tirbanibulin ointment to manage recurrence of superficial basal cell carcinoma of the face: case report.
Martora F, Ascierto PA, Scalvenzi M, Palla M, Costa C, D'Andrea M, Di Trolio R, Scarpato L, Marasca C.
Clin Exp Dermatol · letter; case reports · DOI 10.1093/ced/llad334Anogenital warts in two patients treated with topical tirbanibulin: a new treatment option.
Agostini A, Macagno N, Cavallo F, Quaglino P, Broganelli P.
Ital J Dermatol Venerol · journal article · DOI 10.23736/s2784-8671.23.07740-xPreliminary Evidence of Efficacy, Safety, and Treatment Satisfaction with Tirbanibulin 1% Ointment: A Clinical Perspective on Actinic Keratoses.
Campione E, Rivieccio A, Gaeta Shumak R, Costanza G, Cosio T, Lambiase S, Garofalo V, Artosi F, Lozzi F, Freni C, Romeo A, Dika E, Falconi M, Bianchi L.
Pharmaceuticals (Basel) · research-article; journal article · DOI 10.3390/ph16121686Tirbanibulin: an alternative topical approach to manage superficial basal cell carcinoma. Comment on: 'Successful treatment of field cancerization on the dorsum of the hands with 1% tirbanibulin ointment'.
Martora F, Ascierto P, Palla M, Costa C, D'Andrea M, Di Trolio R, Scarpato L, Marasca C.
Clin Exp Dermatol · journal article · DOI 10.1093/ced/llad271Synthesis and evaluation of tirbanibulin derivatives: a detailed exploration of the structure-activity relationship for anticancer activity.
Park J, Kang M, Lim A, Cho KJ, Chae CH, Koh B, Jeon H.
RSC Adv · research-article; journal article · DOI 10.1039/d3ra06790d1% Tirbanibulin Ointment for Actinic Keratoses on Upper Extremities: A Retrospective Case Review Study.
Iglesias-Puzas Á, Conde-Taboada A, Campos-Muñoz L, Sirgado-Martínez A, López-Bran E.
Acta Derm Venereol · brief-report; journal article; case reports · DOI 10.2340/actadv.v103.15296Successful treatment of Bowen disease with 1% tirbanibulin ointment.
Blaya Imbernón D, Finello M, Labrandero Hoyos C, Lorca Spröhnle J, Casanova Esquembre A, Peñuelas Leal R, Grau Echevarría A, Hernández Bel P.
Clin Exp Dermatol · letter · DOI 10.1093/ced/llad231Invasive SCC and Tirbanibulin: Experience in Patient With Epidermodysplasia Verruciformis.
Agostini A, Macagno N, Senetta R, Quaglino P, Broganelli P.
Ann Pharmacother · letter; case reports · DOI 10.1177/10600280231195899Contact Sensitization and Phototoxic and Photoallergic Potential of Tirbanibulin 1% Ointment in Healthy Volunteers.
Dosik J, Cutler DL, Fang J, Padullés L.
JID Innov · research-article; journal article · DOI 10.1016/j.xjidi.2022.100170Tirbanibulin for Actinic Keratosis: Insights into the Mechanism of Action.
Schlesinger T, Stockfleth E, Grada A, Berman B.
Clin Cosmet Investig Dermatol · review-article; review; journal article · DOI 10.2147/ccid.s374122Topical Tirbanibulin, a Dual Src Kinase and Tubulin Polymerization Inhibitor, for the Treatment of Plaque-Type Psoriasis: Phase I Results.
Hong JB, Wu PY, Qin A, Huang YW, Tseng KC, Lai CY, Chan WK, Fang J, Cutler DL, Tsai TF.
Pharmaceutics · research-article; journal article · DOI 10.3390/pharmaceutics14102159SAR Probing of KX2-391 Provided Analogues With Juxtaposed Activity Profile Against Major Oncogenic Kinases.
Omar AM, Khayat MT, Ahmed F, Muhammad YA, Malebari AM, Ibrahim SM, Khan MI, Shah DK, Childers WE, El-Araby ME.
Front Oncol · research-article; journal article · DOI 10.3389/fonc.2022.879457A phase Ib dose escalation study of oral monotherapy with KX2-391 in elderly patients with acute myeloid leukemia.
Kasner MT, Halloran MB, Pan J, Ritchie EK, Fetterly GJ, Kramer D, Hangauer DG, Thompson JE.
Invest New Drugs · research support, non-u.s. gov't; multicenter study; clinical trial, phase i; journal article · DOI 10.1007/s10637-022-01255-1Tirbanibulin: review of its novel mechanism of action and how it fits into the treatment of actinic keratosis.
Gilaberte Y, Fernández-Figueras MT.
Actas Dermosifiliogr (Engl Ed) · review; journal article · DOI 10.1016/j.ad.2021.07.006Tirbanibulin Attenuates Pulmonary Fibrosis by Modulating Src/STAT3 Signaling.
Wang X, Ren R, Xu Z, Huang H, Jiang W, Ma J.
Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2021.693906Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis.
Kim S, Min A, Lee KH, Yang Y, Kim TY, Lim JM, Park SJ, Nam HJ, Kim JE, Song SH, Han SW, Oh DY, Kim JH, Kim TY, Hangauer D, Lau JY, Im K, Lee DS, Bang YJ, Im SA.
Cancer Res Treat · research-article; journal article · DOI 10.4143/crt.2016.168