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Publikationer som ChEBI hänvisar till för JHU083. Visa hela publikationsregistret

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Publications in the selection

22 hits

Bibliografisk träff 2024-07-01

Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers.

Praharaj M, Shen F, Lee AJ, Zhao L, Nirschl TR, Theodros D, Singh AK, Wang X, Adusei KM, Lombardo KA, Williams RA, Sena LA, Thompson EA, Tam A, Yegnasubramanian S, Pearce EJ, Leone RD, Alt J, Rais R, Slusher BS, Pardoll DM, Powell JD, Zarif JC.

Cancer Immunol Res · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1158/2326-6066.cir-23-1105

Bibliografisk träff 2024-06-01

Glutaminase - A potential target for cancer treatment.

Anthony J, Varalakshmi S, Sekar AK, Devarajan N, Janakiraman B, Peramaiyan R.

Biomedicine (Taipei) · review-article; review; journal article · DOI 10.37796/2211-8039.1445

Bibliografisk träff 2024-02-22

Targeting glutamine metabolism exhibits anti-tumor effects in thyroid cancer.

Zhang GQ, Xi C, Ju NT, Shen CT, Qiu ZL, Song HJ, Luo QY.

J Endocrinol Invest · research-article; journal article · DOI 10.1007/s40618-023-02294-y

Bibliografisk träff 2023-11-16

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis.

Parveen S, Shen J, Lun S, Zhao L, Alt J, Koleske B, Leone RD, Rais R, Powell JD, Murphy JR, Slusher BS, Bishai WR.

Nat Commun · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41467-023-43304-0

Bibliografisk träff 2023-06-22

T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade.

Lee K, Thompson EA, Gharaie S, Patel CH, Kurzhagen JT, Pierorazio PM, Arend LJ, Thomas AG, Noel S, Slusher BS, Rabb H.

JCI Insight · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1172/jci.insight.160345

Bibliografisk träff 2023-05-03

H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells.

Liu C, Wu X, Bing X, Qi W, Zhu F, Guo N, Li C, Gao X, Cao X, Zhao M, Xia M.

Free Radic Biol Med · research support, non-u.s. gov't; journal article · DOI 10.1016/j.freeradbiomed.2023.05.004

Bibliografisk träff 2022-12-16

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.

Kaushik AK, Tarangelo A, Boroughs LK, Ragavan M, Zhang Y, Wu CY, Li X, Ahumada K, Chiang JC, Tcheuyap VT, Saatchi F, Do QN, Yong C, Rosales T, Stevens C, Rao AD, Faubert B, Pachnis P, Zacharias LG, Vu H, Cai F, Mathews TP, Genovese G, Slusher BS, Kapur P, Sun X, Merritt M, Brugarolas J, DeBerardinis RJ.

Sci Adv · research-article; journal article · DOI 10.1126/sciadv.abp8293

Bibliografisk träff 2022-10-04

Glutaminase 1 blockade alleviates nonalcoholic steatohepatitis via promoting proline metabolism.

Tu H, Yin X, Wen J, Wu W, Zhai B, Li J, Jiang H.

Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2022.10.007

Bibliografisk träff 2022-07-21

Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR-Driven Lung Cancer.

Huang M, Xiong D, Pan J, Zhang Q, Sei S, Shoemaker RH, Lubet RA, Montuenga LM, Wang Y, Slusher BS, You M.

Adv Sci (Weinh) · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1002/advs.202105885

Bibliografisk träff 2022-06-09

Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice.

Bell BJ, Hollinger KR, Deme P, Sakamoto S, Hasegawa Y, Volsky D, Kamiya A, Haughey N, Zhu X, Slusher BS.

Brain Behav Immun Health · brief-report; journal article · DOI 10.1016/j.bbih.2022.100478

Bibliografisk träff 2022-05-19

Targeting Glutamine Metabolism Ameliorates Autoimmune Hepatitis via Inhibiting T Cell Activation and Differentiation.

Yu Q, Tu H, Yin X, Peng C, Dou C, Yang W, Wu W, Guan X, Li J, Yan H, Zang Y, Jiang H, Xia Q.

Front Immunol · research support, non-u.s. gov't; research-article; journal article · DOI 10.3389/fimmu.2022.880262

Bibliografisk träff 2021-09-01

Correction to: Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.

Nedelcovych MT, Kim BH, Zhu X, Lovell LE, Manning AA, Kelschenbach J, Hadas E, Chao W, Prchalová E, Dash RP, Wu Y, Alt J, Thomas AG, Rais R, Kamiya A, Volsky DJ, Slusher BS.

J Neuroimmune Pharmacol · published erratum · DOI 10.1007/s11481-021-09992-5

Bibliografisk träff 2021-05-25

Inhibitory Effect of a Glutamine Antagonist on Proliferation and Migration of VSMCs via Simultaneous Attenuation of Glycolysis and Oxidative Phosphorylation.

Park HY, Kim MJ, Lee S, Jin J, Lee S, Kim JG, Choi YK, Park KG.

Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms22115602

Bibliografisk träff 2020-10-29

The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling.

Yamashita AS, da Costa Rosa M, Stumpo V, Rais R, Slusher BS, Riggins GJ.

Neurooncol Adv · research-article; journal article · DOI 10.1093/noajnl/vdaa149

Bibliografisk träff 2020-02-01

Tumor Microenvironment, Metabolism, and Immunotherapy.

DeBerardinis RJ.

N Engl J Med · journal article · DOI 10.1056/nejmcibr1914890

Bibliografisk träff 2020-01-01

Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice.

Hollinger KR, Zhu X, Khoury ES, Thomas AG, Liaw K, Tallon C, Wu Y, Prchalova E, Kamiya A, Rojas C, Kannan S, Slusher BS.

J Alzheimers Dis · research-article; journal article; research support, n.i.h., extramural · DOI 10.3233/jad-190588

Bibliografisk träff 2019-08-29

Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.

Hollinger KR, Smith MD, Kirby LA, Prchalova E, Alt J, Rais R, Calabresi PA, Slusher BS.

Neurol Neuroimmunol Neuroinflamm · research-article; journal article; research support, n.i.h., extramural · DOI 10.1212/nxi.0000000000000609

Bibliografisk träff 2019-07-21

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma.

Hanaford AR, Alt J, Rais R, Wang SZ, Kaur H, Thorek DLJ, Eberhart CG, Slusher BS, Martin AM, Raabe EH.

Transl Oncol · research-article; journal article · DOI 10.1016/j.tranon.2019.05.013

Bibliografisk träff 2019-06-17

Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.

Nedelcovych MT, Kim BH, Zhu X, Lovell LE, Manning AA, Kelschenbach J, Hadas E, Chao W, Prchalová E, Dash RP, Wu Y, Alt J, Thomas AG, Rais R, Kamiya A, Volsky DJ, Slusher BS.

J Neuroimmune Pharmacol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1007/s11481-019-09859-w

Bibliografisk träff 2019-03-13

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A.

Neuropsychopharmacology · published erratum; correction; journal article · DOI 10.1038/s41386-019-0354-3

Bibliografisk träff 2018-12-04

MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.

Riggle BA, Sinharay S, Schreiber-Stainthorp W, Munasinghe JP, Maric D, Prchalova E, Slusher BS, Powell JD, Miller LH, Pierce SK, Hammoud DA.

Proc Natl Acad Sci U S A · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1073/pnas.1812909115

Bibliografisk träff 2018-08-13

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A.

Neuropsychopharmacology · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41386-018-0177-7

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Publications in the selection

Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers.

Glutaminase - A potential target for cancer treatment.

Targeting glutamine metabolism exhibits anti-tumor effects in thyroid cancer.

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis.

T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade.

H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells.

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.

Glutaminase 1 blockade alleviates nonalcoholic steatohepatitis via promoting proline metabolism.

Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR-Driven Lung Cancer.

Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice.

Targeting Glutamine Metabolism Ameliorates Autoimmune Hepatitis <i>via</i> Inhibiting T Cell Activation and Differentiation.

Correction to: Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.

Inhibitory Effect of a Glutamine Antagonist on Proliferation and Migration of VSMCs via Simultaneous Attenuation of Glycolysis and Oxidative Phosphorylation.

The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling.

Tumor Microenvironment, Metabolism, and Immunotherapy.

Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice.

Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma.

Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b<sup>+</sup> cells and prevents depression-associated behaviors induced by chronic social defeat stress.

MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.

JHU-083 selectively blocks glutaminase activity in brain CD11b<sup>+</sup> cells and prevents depression-associated behaviors induced by chronic social defeat stress.