Targeting of STAT5 using the small molecule topotecan hydrochloride suppresses acute myeloid leukemia progression.
Li J, Tang B, Miao Y, Li G, Sun Z.
Oncol Rep · research-article; journal article · DOI 10.3892/or.2023.8645 PUBLICATION REGISTRY
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8 hitsCamptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise.
Khaiwa N, Maarouf NR, Darwish MH, Alhamad DWM, Sebastian A, Hamad M, Omar HA, Orive G, Al-Tel TH.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2021.113639Synthesis of novel 10-hydroxycamptothecin derivatives utilizing topotecan hydrochloride as ortho-quinonemethide precursor.
Tan H, Wang G, Li J, Meng G, Liu Z, Dong M, Li Y, Ju D, Zhang Q.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2014.11.020A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.
Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, Gonzalez-Alvarez I, García-Giménez JL, Díaz Cabañas MJ, Bermejo M, Corma A.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.06.050Semisynthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins.
Samorì C, Guerrini A, Varchi G, Fontana G, Bombardelli E, Tinelli S, Beretta GL, Basili S, Moro S, Zunino F, Battaglia A.
J Med Chem · journal article · DOI 10.1021/jm801153ySynthesis and cytotoxicity of water soluble quaternary salt derivatives of camptothecin.
Zu YG, Li QY, Fu YJ, Wang W.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.05.032Design and optimization of 20-O-linked camptothecin glycoconjugates as anticancer agents.
Lerchen HG, Baumgarten J, von dem Bruch K, Lehmann TE, Sperzel M, Kempka G, Fiebig HH.
J Med Chem · journal article · DOI 10.1021/jm010893lSynthesis, topoisomerase I inhibitory activity, and in vivo evaluation of 11-azacamptothecin analogs.
Uehling DE, Nanthakumar SS, Croom D, Emerson DL, Leitner PP, Luzzio MJ, McIntyre G, Morton B, Profeta S, Sisco J.
J Med Chem · journal article · DOI 10.1021/jm00007a008