Discovery of new LXRβ agonists as glioblastoma inhibitors.
Chen H, Chen Z, Zhang Z, Li Y, Zhang S, Jiang F, Wei J, Ding P, Zhou H, Gu Q, Xu J.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112240 PUBLICATION REGISTRY
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6 hitsIdentify liver X receptor β modulator building blocks by developing a fluorescence polarization-based competition assay.
Zhang Z, Chen H, Chen Z, Ding P, Ju Y, Gu Q, Xu J, Zhou H.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.06.011DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators.
Heitel P, Achenbach J, Moser D, Proschak E, Merk D.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2017.01.066Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.
Hu B, Unwalla RJ, Goljer I, Jetter JW, Quinet EM, Berrodin TJ, Basso MD, Feingold IB, Nilsson AG, Wilhelmsson A, Evans MJ, Wrobel JE.
J Med Chem · journal article · DOI 10.1021/jm100034xQuinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.
Hu B, Bernotas R, Unwalla R, Collini M, Quinet E, Feingold I, Goos-Nilsson A, Wilhelmsson A, Nambi P, Evans M, Wrobel J.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.11.062Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
Wrobel J, Steffan R, Bowen SM, Magolda R, Matelan E, Unwalla R, Basso M, Clerin V, Gardell SJ, Nambi P, Quinet E, Reminick JI, Vlasuk GP, Wang S, Feingold I, Huselton C, Bonn T, Farnegardh M, Hansson T, Nilsson AG, Wilhelmsson A, Zamaratski E, Evans MJ.
J Med Chem · journal article · DOI 10.1021/jm800799q