Redox regulation of cutaneous AMPs by ozone in tensioned skin models.
Ivarsson J, Pambianchi E, Pecorelli A, Lim Y, Valacchi G.
Arch Biochem Biophys · research support, non-u.s. gov't; journal article · DOI 10.1016/j.abb.2025.110409 PUBLICATION REGISTRY
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Publikationer som ChEBI hänvisar till för VAS2870. Visa hela publikationsregistret
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Publications in the selection
27 hitsDesign of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor.
Noce B, Marchese S, Massari M, Lambona C, Reis J, Fiorentino F, Raucci A, Fioravanti R, Castelôa M, Mormino A, Garofalo S, Limatola C, Basile L, Gottinger A, Binda C, Mattevi A, Mai A, Valente S.
J Med Chem · research-article; journal article · DOI 10.1021/acs.jmedchem.4c02644NADPH oxidase derived ROS promote arterial contraction in early postnatal rats by activation of L-type voltage-gated Ca<sup>2+</sup> channels.
Shvetsova AA, Shateeva VS, Khlystova MA, Makukha YA, Tarasova OS, Gaynullina DK.
Free Radic Res · journal article · DOI 10.1080/10715762.2024.2448483Cinobufotalin inhibits proliferation, migration and invasion in hepatocellular carcinoma by triggering NOX4/NLRP3/GSDMD-dependent pyroptosis.
Liu C, Wu J, Li Z, Huang X, Xie X, Huang Y.
Front Oncol · research-article; journal article · DOI 10.3389/fonc.2024.1438306PM2.5 Exposure Aggravates Inflammatory Response and Mucus Production in 16HBE Cells through Inducing Oxidative Stress and RAGE Expression.
Han H, Peng X, Huang M, Zhao W, Yang S, Lan Z, Cai S, Zhao H.
Cell Biochem Biophys · journal article · DOI 10.1007/s12013-024-01526-zReactive oxygen species augment contractile responses of saphenous artery in 10-15-day-old but not adult rats: Substantial role of NADPH oxidases.
Shvetsova AA, Khlystova MA, Makukha YA, Shateeva VS, Borzykh AA, Gaynullina DK, Tarasova OS.
Free Radic Biol Med · journal article · DOI 10.1016/j.freeradbiomed.2024.03.005Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation.
Jiang Y, Xu L, Zhu X, Zhu X, Xu X, Li J.
Redox Rep · research-article; journal article · DOI 10.1080/13510002.2024.2324234The antiangiogenic effect of digitoxin is dependent on a ROS-elicited RhoA/ROCK pathway activation.
Boscaro C, Schimdt G, Cignarella A, Dal Maso L, Bolego C, Trevisi L.
Biochem Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bcp.2024.116049NADPH oxidase 1: A target in the capacity of dimeric ECG and EGCG procyanidins to inhibit colorectal cancer cell invasion.
Zhu W, Oteiza PI.
Redox Biol · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.redox.2023.102827Inhibition of NADPH Oxidase (NOX) 2 Mitigates Colitis in Mice with Impaired Macrophage AMPK Function.
Banskota S, Wang H, Kwon YH, Gautam J, Haq S, Grondin J, Steinberg GR, Khan WI.
Biomedicines · research-article; journal article · DOI 10.3390/biomedicines11051443NADPH and xanthine oxidases control induction of inflammatory mediator expression by organic dust in the lung.
Meganathan V, Hamilton CE, Natarajan K, Keshava S, Boggaram V.
FASEB J · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1096/fj.202100732rInhibition of the NADPH Oxidase Pathway Reduces Ferroptosis during Septic Renal Injury in Diabetic Mice.
Yao W, Liao H, Pang M, Pan L, Guan Y, Huang X, Hei Z, Luo C, Ge M.
Oxid Med Cell Longev · research-article; journal article · DOI 10.1155/2022/1193734Inhibition of LPS-induced Nox2 activation by VAS2870 protects alveolar epithelial cells through eliminating ROS and restoring tight junctions.
Li D, Cong Z, Yang C, Zhu X.
Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2020.01.134VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC.
Lu WJ, Li JY, Chen RJ, Huang LT, Lee TY, Lin KH.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41598-019-55189-5Inhibition of the thyroid hormonogenic H<sub>2</sub>O<sub>2</sub> production by Duox/DuoxA in zebrafish reveals VAS2870 as a new goitrogenic compound.
Giusti N, Gillotay P, Trubiroha A, Opitz R, Dumont JE, Costagliola S, De Deken X.
Mol Cell Endocrinol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.mce.2019.110635(-)-Epicatechin and NADPH oxidase inhibitors prevent bile acid-induced Caco-2 monolayer permeabilization through ERK1/2 modulation.
Wang Z, Litterio MC, Müller M, Vauzour D, Oteiza PI.
Redox Biol · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/j.redox.2019.101360VAS2870 Inhibits Histamine-Induced Calcium Signaling and vWF Secretion in Human Umbilical Vein Endothelial Cells.
Avdonin PV, Rybakova EY, Avdonin PP, Trufanov SK, Mironova GY, Tsitrina AA, Goncharov NV.
Cells · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/cells8020196NADPH oxidase inhibitor VAS2870 prevents staurosporine-induced cell death in rat astrocytes.
Simenc J, Juric DM, Lipnik-Stangelj M.
Radiol Oncol · research support, non-u.s. gov't; research-article; journal article · DOI 10.2478/raon-2019-0002ROS scavenger, N-acetyl-l-cysteine and NOX specific inhibitor, VAS2870 reduce platelets apoptosis while enhancing their viability during storage.
Hosseini E, Ghasemzadeh M, Atashibarg M, Haghshenas M.
Transfusion · research support, non-u.s. gov't; journal article · DOI 10.1111/trf.15114NADPH oxidase-generated reactive oxygen species in mature follicles are essential for <i>Drosophila</i> ovulation.
Li W, Young JF, Sun J.
Proc Natl Acad Sci U S A · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1073/pnas.1800115115Novel NADPH oxidase inhibitor VAS2870 suppresses TGF‑β‑dependent epithelial‑to‑mesenchymal transition in retinal pigment epithelial cells.
Yang J, Li J, Wang Q, Xing Y, Tan Z, Kang Q.
Int J Mol Med · research-article; journal article · DOI 10.3892/ijmm.2018.3612NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.
Moon JS, Nakahira K, Chung KP, DeNicola GM, Koo MJ, Pabón MA, Rooney KT, Yoon JH, Ryter SW, Stout-Delgado H, Choi AM.
Nat Med · retracted publication; research-article; journal article · DOI 10.1038/nm.4153VAS2870 is a pan-NADPH oxidase inhibitor.
Wingler K, Altenhoefer SA, Kleikers PW, Radermacher KA, Kleinschnitz C, Schmidt HH.
Cell Mol Life Sci · letter; comment · DOI 10.1007/s00018-012-1107-1Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870).
Sun QA, Hess DT, Wang B, Miyagi M, Stamler JS.
Free Radic Biol Med · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.freeradbiomed.2012.02.046The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-β-induced apoptosis of liver tumor cells.
Sancho P, Fabregat I.
Biochem Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bcp.2011.01.007Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells.
Stielow C, Catar RA, Muller G, Wingler K, Scheurer P, Schmidt HH, Morawietz H.
Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2006.03.114Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation.
ten Freyhaus H, Huntgeburth M, Wingler K, Schnitker J, Bäumer AT, Vantler M, Bekhite MM, Wartenberg M, Sauer H, Rosenkranz S.
Cardiovasc Res · journal article · DOI 10.1016/j.cardiores.2006.01.022