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Publikationer som ChEBI hänvisar till för methylthioadenosine-DADMe immucillin-A. Visa hela publikationsregistret

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Publications in the selection

21 hits

Bibliografisk träff 2025-06-30

The anti-cancer transition-state inhibitor MTDIA inhibits human MTAP, inducing autophagy in humanized yeast.

Coorey NV, Tollestrup I, Bircham PW, Sheridan JP, Evans GB, Schramm VL, Atkinson PH, Munkacsi AB.

Dis Model Mech · research support, non-u.s. gov't; research-article; journal article · DOI 10.1242/dmm.052173

Bibliografisk träff 2023-11-23

Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.

Bedard GT, Gilaj N, Peregrina K, Brew I, Tosti E, Shaffer K, Tyler PC, Edelmann W, Augenlicht LH, Schramm VL.

J Biol Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.jbc.2023.105492

Bibliografisk träff 2023-06-08

Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitor.

Salita T, Rustam YH, Hofferek V, Jackson M, Tollestrup I, Sheridan JP, Schramm VL, Evans GB, Reid GE, Munkacsi AB.

Biochim Biophys Acta Mol Cell Biol Lipids · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbalip.2023.159346

Bibliografisk träff 2023-03-15

MAT Gain of Activity Mutation in <i>Helicobacter pylori</i> Is Associated with Resistance to MTAN Transition State Analogues.

Feng M, Namanja-Magliano H, Rajagopalan S, Mishra T, Ducati RG, Hirsch BM, Kelly L, Szymczak W, Fajardo JE, Sidoli S, Fiser A, Jacobs WR, Schramm VL.

ACS Infect Dis · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acsinfecdis.2c00644

Bibliografisk träff 2021-04-23

Transition state analogue of MTAP extends lifespan of APC<sup>Min/+</sup> mice.

Firestone RS, Feng M, Basu I, Peregrina K, Augenlicht LH, Schramm VL.

Sci Rep · research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41598-021-87734-6

Bibliografisk träff 2020-02-11

Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases.

Zhang D, Burdette BE, Wang Z, Karn K, Li HY, Schramm VL, Tyler PC, Evans GB, Wang S.

Biochemistry · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.biochem.9b01092

Bibliografisk träff 2016-12-27

Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase.

Firestone RS, Cameron SA, Karp JM, Arcus VL, Schramm VL.

ACS Chem Biol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acschembio.6b00885

Bibliografisk träff 2015-07-30

Tight binding enantiomers of pre-clinical drug candidates.

Evans GB, Cameron SA, Luxenburger A, Guan R, Suarez J, Thomas K, Schramm VL, Tyler PC.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2015.07.059

Bibliografisk träff 2014-11-11

Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.

Tang B, Kadariya Y, Chen Y, Slifker M, Kruger WD.

G3 (Bethesda) · research-article; journal article; research support, n.i.h., extramural · DOI 10.1534/g3.114.014555

Bibliografisk träff 2014-02-21

Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase.

Wang S, Thomas K, Schramm VL.

Biochemistry · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/bi401589n

Bibliografisk träff 2013-11-08

Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase.

Guan R, Tyler PC, Evans GB, Schramm VL.

Biochemistry · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/bi401188w

Bibliografisk träff 2012-07-14

Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics.

Clinch K, Evans GB, Fröhlich RF, Gulab SA, Gutierrez JA, Mason JM, Schramm VL, Tyler PC, Woolhouse AD.

Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2012.07.006

Bibliografisk träff 2011-01-01

Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes.

Schramm VL.

Annu Rev Biochem · research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1146/annurev-biochem-061809-100742

Bibliografisk träff 2010-12-06

Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.

Basu I, Locker J, Cassera MB, Belbin TJ, Merino EF, Dong X, Hemeon I, Evans GB, Guha C, Schramm VL.

J Biol Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m110.198374

Bibliografisk träff 2009-03-08

Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.

Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL.

Nat Chem Biol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1038/nchembio.153

Bibliografisk träff 2008-01-01

Transition state analogues in quorum sensing and SAM recycling.

Schramm VL, Gutierrez JA, Cordovano G, Basu I, Guha C, Belbin TJ, Evans GB, Tyler PC, Furneaux RH.

Nucleic Acids Symp Ser (Oxf) · research-article; journal article · DOI 10.1093/nass/nrn038

Bibliografisk träff 2007-06-04

A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers.

Basu I, Cordovano G, Das I, Belbin TJ, Guha C, Schramm VL.

J Biol Chem · journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m702287200

Bibliografisk träff 2006-10-01

Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.

Singh V, Shi W, Almo SC, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Mee S, Zheng R, Schramm VL.

Biochemistry · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/bi061184i

Bibliografisk träff 2005-03-04

Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli.

Singh V, Evans GB, Lenz DH, Mason JM, Clinch K, Mee S, Painter GF, Tyler PC, Furneaux RH, Lee JE, Howell PL, Schramm VL.

J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.m414472200

Bibliografisk träff 2005-03-03

Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.

Lee JE, Singh V, Evans GB, Tyler PC, Furneaux RH, Cornell KA, Riscoe MK, Schramm VL, Howell PL.

J Biol Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1074/jbc.m414471200

Bibliografisk träff 2004-01-01

Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.

Singh V, Shi W, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL.

Biochemistry · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/bi0358420