The synthetic opioid isotonitazene induces locomotor activity and reward effects through modulation of the central dopaminergic system in mice.
Tomiyama KI, Funada M.
Toxicol Appl Pharmacol · journal article · DOI 10.1016/j.taap.2025.117361 PUBLICATION REGISTRY
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24 hitsLCMS Detection and Characterization of In Vitro Metabolites of Isotonitazene, a Targeted Strategy for Novel Psychoactive Substance Control in Camel Racing.
Nalakath J, Thacholil RP, Kadry A, P S, Praseen OK.
Rapid Commun Mass Spectrom · journal article · DOI 10.1002/rcm.9982Discriminative stimulus and antinociceptive effects of sixteen nitazene analogs in rodents.
Gatch MB, Hill RD, Sundar M, Shetty RA.
Neuropharmacology · journal article · DOI 10.1016/j.neuropharm.2025.110416Naloxone Dosing and Hospitalization for Nitazene Overdose: A Scoping Review.
Berger JC, Severe AD, Jalloh MS, Manini AF.
J Med Toxicol · scoping review; review-article; journal article · DOI 10.1007/s13181-025-01059-8Nitazene test strips: a laboratory evaluation.
De Vrieze LM, Stove CP, Vandeputte MM.
Harm Reduct J · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s12954-024-01078-8Detection of N-desethyl etonitazene in a drug checking sample: Chemical analysis and pharmacological characterization of a recent member of the 2-benzylbenzimidazole "nitazene" class.
Monti MC, De Vrieze LM, Vandeputte MM, Persson M, Gréen H, Stove CP, Schlotterbeck G.
J Pharm Biomed Anal · journal article · DOI 10.1016/j.jpba.2024.116453Metabolic characterization of the new benzimidazole synthetic opioids - nitazenes.
Jadhav GR, Fasinu PS.
Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2024.1434573Using forensic intelligence as a model for determining future toxicology methods: TBI forensic toxicology and forensic drug chemistry nitazene identification.
Gray A, Douglas S, Tiller M, Bleakley M.
J Anal Toxicol · journal article · DOI 10.1093/jat/bkae035Isotonitazene, a synthetic opioid from an emerging family: The nitazenes.
Bendjilali-Sabiani JJ, Eiden C, Lestienne M, Cherki S, Gautre D, Van den Broek T, Mathieu O, Peyrière H.
Therapie · journal article · DOI 10.1016/j.therap.2024.05.004Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene.
Taoussi O, Berardinelli D, Zaami S, Tavoletta F, Basile G, Kronstrand R, Auwärter V, Busardò FP, Carlier J.
Arch Toxicol · research-article; journal article · DOI 10.1007/s00204-024-03735-0Validation of an analytical method for quantitation of metonitazene and isotonitazene in plasma, blood, urine, liver and brain and application to authentic postmortem casework in New York City.
Pardi J, Ford S, Cooper G.
J Anal Toxicol · journal article · DOI 10.1093/jat/bkad062Quantification of the benzimidazole opioid analog isotonitazene in human hair using liquid chromatography-tandem mass spectrometry.
Zhao K, Dai Y, Wang Y, Liu J, Gu J, Bai H, Wurita A, Hasegawa K.
Leg Med (Tokyo) · journal article; case reports · DOI 10.1016/j.legalmed.2023.102295Isotonitazene, a novel psychoactive substance opioid, detected in two cases following a local surge in opioid overdoses.
De Baerdemaeker KSC, Dines AM, Hudson S, Sund LJ, Waters ML, Hunter LJ, Blundell MS, Archer JRH, Wood DM, Dargan PI.
QJM · journal article; case reports · DOI 10.1093/qjmed/hcac039Plasma pharmacokinetics and pharmacodynamic effects of the 2-benzylbenzimidazole synthetic opioid, isotonitazene, in male rats.
Walton SE, Krotulski AJ, Glatfelter GC, Walther D, Logan BK, Baumann MH.
Psychopharmacology (Berl) · research-article; journal article · DOI 10.1007/s00213-022-06292-5Pharmacological characterization of novel synthetic opioids: Isotonitazene, metonitazene, and piperidylthiambutene as potent μ-opioid receptor agonists.
De Luca MA, Tocco G, Mostallino R, Laus A, Caria F, Musa A, Pintori N, Ucha M, Poza C, Ambrosio E, Di Chiara G, Castelli MP.
Neuropharmacology · research support, non-u.s. gov't; journal article · DOI 10.1016/j.neuropharm.2022.109263Development of a non-radioactive mass spectrometry-based binding assay at the μ-opioid receptor and its application for the determination of the binding affinities of 17 opiates/opioids as well as of the designer opioid isotonitazene and five further 2-benzylbenzimidazoles.
Volz MR, Moosmann B.
Anal Chim Acta · journal article · DOI 10.1016/j.aca.2022.339978A Vaccine against Benzimidazole-Derived New Psychoactive Substances That Are More Potent Than Fentanyl.
Lee JC, Park H, Eubanks LM, Ellis B, Zhou B, Janda KD.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.1c01967Isotonitazene: a new synthetic opioid in the UK.
Nahar LK, Andrews R, Paterson S.
BMJ · letter · DOI 10.1136/bmj.n3143Emerging Characteristics of Isotonitazene-Involved Overdose Deaths: A Case-Control Study.
Shover CL, Falasinnu TO, Freedman RB, Humphreys K.
J Addict Med · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1097/adm.0000000000000775The Rise and Fall of Isotonitazene and Brorphine: Two Recent Stars in the Synthetic Opioid Firmament.
Vandeputte MM, Krotulski AJ, Papsun DM, Logan BK, Stove CP.
J Anal Toxicol · journal article · DOI 10.1093/jat/bkab082Isotonitazene: Fatal intoxication in three cases involving this unreported novel psychoactive substance in Switzerland.
Mueller F, Bogdal C, Pfeiffer B, Andrello L, Ceschi A, Thomas A, Grata E.
Forensic Sci Int · journal article; case reports · DOI 10.1016/j.forsciint.2021.110686Isotonitazene as a contaminant of concern in the illegal opioid supply: A practical synthesis and cost perspective.
Zagorski CM, Myslinski JM, Hill LG.
Int J Drug Policy · journal article · DOI 10.1016/j.drugpo.2020.102939Isotonitazene Quantitation and Metabolite Discovery in Authentic Forensic Casework.
Krotulski AJ, Papsun DM, Kacinko SL, Logan BK.
J Anal Toxicol · journal article · DOI 10.1093/jat/bkaa016Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene.
Blanckaert P, Cannaert A, Van Uytfanghe K, Hulpia F, Deconinck E, Van Calenbergh S, Stove C.
Drug Test Anal · journal article · DOI 10.1002/dta.2738