A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE.
Lin J, Nie Q, Cheng J, Zhong YN, Zhang T, Zhang X, Ge X, Ding Y, Niu C, Gao Y, Wang K, Gao M, Wang X, Chen W, Yun C, Ye C, Xu J, Shaoyong W, Zhang L, Shang P, Luo X, Zhang Z, Zheng X, Sha X, Zhang J, Nie S, Zhang X, Ren F, Liu H, Dong E, Yu X, Ji L, Pang Y, Sun JP, Jiang C.
Cell · journal article · DOI 10.1016/j.cell.2025.05.010