Inhibiting the "Undruggable" RAS/Farnesyltransferase (FTase) Cancer Target by Manumycin-related Natural Products.
Silva LR, da Silva-Júnior EF.
Curr Med Chem · review; journal article · DOI 10.2174/0929867328666210315123848 PUBLICATION REGISTRY
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25 hitsInhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A.
Sojka DR, Hasterok S, Vydra N, Toma-Jonik A, Wieczorek A, Gogler-Pigłowska A, Scieglinska D.
Cells · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/cells10061418Inhibition of Pro-Inflammatory Cytokines by Metabolites of Streptomycetes-A Potential Alternative to Current Anti-Inflammatory Drugs?
Hrdý J, Súkeníková L, Petrásková P, Novotná O, Kahoun D, Petříček M, Chroňáková A, Petříčková K.
Microorganisms · research-article; journal article · DOI 10.3390/microorganisms8050621Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells.
Macejová M, Sačková V, Hradická P, Jendželovský R, Demečková V, Fedoročko P.
Toxicol In Vitro · journal article · DOI 10.1016/j.tiv.2020.104860The P5A ATPase Spf1p is stimulated by phosphatidylinositol 4-phosphate and influences cellular sterol homeostasis.
Sørensen DM, Holen HW, Pedersen JT, Martens HJ, Silvestro D, Stanchev LD, Costa SR, Günther Pomorski T, López-Marqués RL, Palmgren M.
Mol Biol Cell · research support, non-u.s. gov't; research-article; journal article · DOI 10.1091/mbc.e18-06-0365Effectors of thioredoxin reductase: Brevetoxins and manumycin-A.
Tuladhar A, Hondal RJ, Colon R, Hernandez EL, Rein KS.
Comp Biochem Physiol C Toxicol Pharmacol · research-article; journal article · DOI 10.1016/j.cbpc.2018.11.015Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1).
Tuladhar A, Rein KS.
ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.7b00489Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.
Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, Jones JC, Mondal D, Ferrer M, Abdel-Mageed AB.
Cancer Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.canlet.2017.08.020Antitumor effect of the combination of manumycin A and Immodin is associated with antiplatelet activity and increased granulocyte tumor infiltration in a 4T1 breast tumor model.
Solár P, Sačková V, Hrčková G, Demečková V, Kassayová M, Bojková B, Mudroňová D, Gancarčíková S, Jendželovský R, Fedoročko P.
Oncol Rep · journal article · DOI 10.3892/or.2016.5265Antitumor effect of manumycin on colorectal cancer cells by increasing the reactive oxygen species production and blocking PI3K-AKT pathway.
Zhang J, Jiang H, Xie L, Hu J, Li L, Yang M, Cheng L, Liu B, Qian X.
Onco Targets Ther · research-article; journal article · DOI 10.2147/ott.s102408Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway.
Kim KH, Chae JI, Oh H, Cho JH, Lee RH, Yoon G, Cho SS, Cho YS, Lee MH, Liu K, Lee HJ, Shim JH.
Oncol Rep · journal article · DOI 10.3892/or.2016.4801Stimulating Effect of Manumycin A on Suicidal Erythrocyte Death.
Egler J, Zierle J, Lang F.
Cell Physiol Biochem · research support, non-u.s. gov't; journal article · DOI 10.1159/000443065Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes.
Cecrdlova E, Petrickova K, Petrickova K, Kolesar L, Petricek M, Sekerkova A, Svachova V, Striz I.
Immunol Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.imlet.2015.11.010The natural tumorcide Manumycin-A targets protein phosphatase 1α and reduces hydrogen peroxide to induce lymphoma apoptosis.
Carey GB, Roy SK, Daino H.
Exp Cell Res · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.yexcr.2014.12.009Manumycin induces apoptosis in prostate cancer cells.
Li JG, She MR, Lu CY, Wei SS, Xia PF, Lu ZS, Peng Q.
Onco Targets Ther · research-article; journal article · DOI 10.2147/ott.s60253Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model.
Tsuda M, Okamoto K, Muguruma N, Sannomiya K, Nakagawa T, Miyamoto H, Kitamura S, Goji T, Kimura T, Okahisa T, Izumi K, Takayama T.
J Gastroenterol Hepatol · research support, non-u.s. gov't; journal article · DOI 10.1111/jgh.12287Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death.
Singha PK, Pandeswara S, Venkatachalam MA, Saikumar P.
Cell Death Dis · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/cddis.2012.192Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice.
Oana K, Oma Y, Suo S, Takahashi MP, Nishino I, Takeda S, Ishiura S.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/srep02142Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A.
Sačková V, Kuliková L, Kello M, Uhrinová I, Fedoročko P.
Int J Mol Sci · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/ijms12128388The prenylation inhibitor manumycin A reduces the viability of Anaplasma phagocytophilum.
Xiong Q, Rikihisa Y.
J Med Microbiol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1099/jmm.0.029231-0Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice.
Sugita M, Sugita H, Kaneki M.
Arterioscler Thromb Vasc Biol · journal article; research support, n.i.h., extramural · DOI 10.1161/atvbaha.107.140673Chinikomycins A and B: isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp. isolate M045.
Li F, Maskey RP, Qin S, Sattler I, Fiebig HH, Maier A, Zeeck A, Laatsch H.
J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np030518rA novel metal-chelating inhibitor of protein farnesyltransferase.
Hamasaki A, Naka H, Tamanoi F, Umezawa K, Otsuka M.
Bioorg Med Chem Lett · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00183-5Identification of Ras farnesyltransferase inhibitors by microbial screening.
Hara M, Akasaka K, Akinaga S, Okabe M, Nakano H, Gomez R, Wood D, Uh M, Tamanoi F.
Proc Natl Acad Sci U S A · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research-article; journal article · DOI 10.1073/pnas.90.6.2281The structure of manumycin. I. Characterization, structure elucidation and biological activity.
Zeeck A, Schröder K, Frobel K, Grote R, Thiericke R.
J Antibiot (Tokyo) · research support, non-u.s. gov't; journal article · DOI 10.7164/antibiotics.40.1530