Induction of apoptosis and erythroid differentiation of human chronic myelogenous leukemia K562 cells by low concentrations of lidamycin.
Zhang C, Guo LY, Mu D, Gong JH, Chen J.
Oncol Rep · journal article · DOI 10.3892/or.2018.6849 PUBLICATION REGISTRY
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27 hitsThe Recombinant and Reconstituted Novel Albumin-Lidamycin Conjugate Shows Lasting Tumor Imaging and Intensively Enhanced Therapeutic Efficacy.
Li L, Hu L, Zhao CY, Zhang SH, Wang R, Li Y, Shao RG, Zhen YS.
Bioconjug Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.bioconjchem.8b00456Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.
Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B.
Biochemistry · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.biochem.8b00174Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers.
Yan X, Hindra, Ge H, Yang D, Huang T, Crnovcic I, Chang CY, Fang SM, Annaval T, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B.
J Nat Prod · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jnatprod.7b01013Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.
Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN, Shen B.
Biochemistry · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.biochem.6b00713Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.
Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, Joachimiak A, Phillips GN, Shen B.
J Antibiot (Tokyo) · research-article; journal article · DOI 10.1038/ja.2016.88Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluation.
Li W, Li X, Huang T, Teng Q, Crnovcic I, Rader C, Shen B.
Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2016.04.017Complete genome sequence of Streptomyces globisporus C-1027, the producer of an enediyne antibiotic lidamycin.
Li X, Lei X, Zhang C, Jiang Z, Shi Y, Wang S, Wang L, Hong B.
J Biotechnol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jbiotec.2016.02.004The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance.
Beerman TA, Gawron LS, Shen B, Kennedy DR.
DNA Repair (Amst) · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.dnarep.2014.06.001Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis.
Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B.
Org Lett · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/ol300720sImprovement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus.
Chen Y, Yin M, Horsman GP, Shen B.
J Nat Prod · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/np100825yManipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027.
Chen Y, Yin M, Horsman GP, Huang S, Shen B.
J Antibiot (Tokyo) · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/ja.2010.55Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis.
Lin S, Horsman GP, Chen Y, Li W, Shen B.
J Am Chem Soc · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/ja901242sCharacterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027.
Van Lanen SG, Lin S, Horsman GP, Shen B.
FEMS Microbiol Lett · research-article; journal article; research support, n.i.h., extramural · DOI 10.1111/j.1574-6968.2009.01802.xDisruption of cagA, the apoprotein gene of chromoprotein antibiotic C-1027, eliminates holo-antibiotic production, but not the cytotoxic chromophore.
Cui Z, Wang L, Wang S, Li G, Hong B.
FEMS Microbiol Lett · research support, non-u.s. gov't; journal article · DOI 10.1111/j.1574-6968.2009.01800.xRole of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027.
Wang L, Hu Y, Zhang Y, Wang S, Cui Z, Bao Y, Jiang W, Hong B.
BMC Microbiol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/1471-2180-9-14Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.
Lin S, Van Lanen SG, Shen B.
J Am Chem Soc · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/ja710601dBiosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism.
Van Lanen SG, Lin S, Shen B.
Proc Natl Acad Sci U S A · research-article; journal article; research support, n.i.h., extramural · DOI 10.1073/pnas.0708750105Total synthesis of the C-1027 chromophore core: extremely facile enediyne formation through Sml2-mediated 1,2-elimination.
Inoue M, Ohashi I, Kawaguchi T, Hirama M.
Angew Chem Int Ed Engl · research support, non-u.s. gov't; journal article · DOI 10.1002/anie.200704842Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses.
Kennedy DR, Ju J, Shen B, Beerman TA.
Proc Natl Acad Sci U S A · research-article; journal article; research support, n.i.h., extramural · DOI 10.1073/pnas.0708274104Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027.
Lin S, Van Lanen SG, Shen B.
J Am Chem Soc · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/ja072311gSubstrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027.
Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B.
J Biol Chem · journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m605887200ESR studies on DNA cleavage induced by enediyne C-1027 chromophore.
Usuki T, Inoue M, Akiyama K, Hirama M.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2005.05.049Synthesis of the C-1027 chromophore framework through atropselective macrolactonization.
Inoue M, Sasaki T, Hatano S, Hirama M.
Angew Chem Int Ed Engl · research support, non-u.s. gov't; journal article · DOI 10.1002/anie.200461428Synthesis of the bicyclo[7.3.0]dodecatrienediyne core of the C-1027 chromophore.
Inoue M, Hatano S, Kodama M, Sasaki T, Kikuchi T, Hirama M.
Org Lett · journal article · DOI 10.1021/ol048494iBiosynthesis of the enediyne antitumor antibiotic C-1027.
Liu W, Christenson SD, Standage S, Shen B.
Science · research support, u.s. gov't, p.h.s.; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1126/science.1072110A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.
Hu JL, Xue YC, Xie MY, Zhang R, Otani T, Minami Y, Yamada Y, Marunaka T.
J Antibiot (Tokyo) · journal article · DOI 10.7164/antibiotics.41.1575