8-Aminoguanine and its actions in the metabolic syndrome.
Jackson EK, Gillespie DG, Mi Z, Birder LA, Tofovic SP.
Sci Rep · research-article; journal article · DOI 10.1038/s41598-024-73159-4 PUBLICATION REGISTRY
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Publications in the selection
20 hitsPurine nucleoside phosphorylase inhibition is an effective approach for the treatment of chemical hemorrhagic cystitis.
Wolf-Johnston A, Ikeda Y, Zabbarova I, Kanai AJ, Bastacky S, Moldwin R, Stern JN, Jackson EK, Birder LA.
JCI Insight · research-article; journal article; research support, n.i.h., extramural · DOI 10.1172/jci.insight.1761038-Aminopurines in the Cardiovascular and Renal Systems and Beyond.
Jackson EK, Tofovic SP, Chen Y, Birder LA.
Hypertension · research-article; review; journal article · DOI 10.1161/hypertensionaha.123.205828-Aminoguanine and Its Actions on Renal Excretory Function.
Jackson EK, Gillespie DG, Mi Z.
Hypertension · research-article; journal article; research support, n.i.h., extramural · DOI 10.1161/hypertensionaha.122.20760Suppressed renoprotective purines in COVID-19 patients with acute kidney injury.
Jackson EK, Kitsios GD, Lu MY, Schaefer CM, Kessinger CJ, McVerry BJ, Morris A, Macatangay BJC.
Sci Rep · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41598-022-22349-zPurine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction.
Birder LA, Jackson EK.
Nat Rev Urol · research-article; review; journal article; research support, n.i.h., extramural · DOI 10.1038/s41585-022-00642-wSmall molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function.
Tian G, Katchur SR, Jiang Y, Briand J, Schaber M, Kreatsoulas C, Schwartz B, Thrall S, Davis AM, Duvall S, Kaufman BA, Rumsey WL.
Sci Rep · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/s41598-022-18878-28-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity.
Jackson EK, Menshikova EV, Ritov VB, Mi Z, Birder LA.
J Pharmacol Exp Ther · research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/jpet.122.001221Biochemical pathways of 8-aminoguanine production in Sprague-Dawley and Dahl salt-sensitive rats.
Jackson EK, Menshikova EV, Ritov VB, Gillespie DG, Mi Z.
Biochem Pharmacol · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bcp.2022.115076Genotoxic C8-Arylamino-2'-deoxyadenosines Act as Latent Alkylating Agents to Induce DNA Interstrand Cross-Links.
Rozelle AL, Lee S.
J Am Chem Soc · journal article; research support, n.i.h., extramural · DOI 10.1021/jacs.1c07234A uro-protective agent with restorative actions on urethral and striated muscle morphology.
Birder LA, Wolf-Johnston A, Wein AJ, Grove-Sullivan M, Stoltz D, Watkins S, Newman D, Dmochowski RR, Jackson EK.
World J Urol · research-article; journal article · DOI 10.1007/s00345-020-03492-6Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions.
Birder LA, Wolf-Johnston A, Wein AJ, Cheng F, Grove-Sullivan M, Kanai AJ, Watson AM, Stoltz D, Watkins SC, Robertson AM, Newman D, Dmochowski RR, Jackson EK.
JCI Insight · research-article; journal article; research support, n.i.h., extramural · DOI 10.1172/jci.insight.1401098-Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1.
Jackson EK, Mi Z, Kleyman TR, Cheng D.
J Am Heart Assoc · research-article; journal article; research support, n.i.h., extramural · DOI 10.1161/jaha.118.010085Correction to "8-Aminoguanosine and 8-Aminoguanine Exert Diuretic, Natriuretic, Glucosuric, and Antihypertensive Activity".
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J Pharmacol Exp Ther · published erratum; correction; journal article · DOI 10.1124/jpet.114.237552err8-Aminoguanosine Exerts Diuretic, Natriuretic, and Glucosuric Activity via Conversion to 8-Aminoguanine, Yet Has Direct Antikaliuretic Effects.
Jackson EK, Mi Z.
J Pharmacol Exp Ther · research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/jpet.117.2437588-Aminoguanosine and 8-Aminoguanine Exert Diuretic, Natriuretic, Glucosuric, and Antihypertensive Activity.
Jackson EK, Gillespie DG, Mi Z.
J Pharmacol Exp Ther · research-article; journal article · DOI 10.1124/jpet.116.237552Prediction of thymine dimer repair by electron transfer from photoexcited 8-aminoguanine or its deprotonated anion.
Sieradzan I, Marchaj M, Anusiewicz I, Skurski P, Simons J.
J Phys Chem A · research support, non-u.s. gov't; journal article · DOI 10.1021/jp411666aSpecificity of stimulation of human 8-oxoguanine-DNA glycosylase by AP endonuclease.
Sidorenko VS, Nevinsky GA, Zharkov DO.
Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2008.01.076DNA-triplex stabilizing properties of 8-aminoguanine.
Soliva R, Güimil García R, Blas JR, Eritja R, Asensio JL, González C, Luque FJ, Orozco M.
Nucleic Acids Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1093/nar/28.22.4531Inhibitors of purine nucleoside phosphorylase, C(8) and C(5') substitutions.
Stoeckler JD, Cambor C, Kuhns V, Chu SH, Parks RE.
Biochem Pharmacol · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1016/0006-2952(82)90206-4