Pharmacological basis and new insights of deguelin concerning its anticancer effects.
Lin ZY, Yun QZ, Wu L, Zhang TW, Yao TZ.
Pharmacol Res · review; journal article · DOI 10.1016/j.phrs.2021.105935 PUBLICATION REGISTRY
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24 hitsNovel B, C-ring truncated deguelin derivatives reveals as potential inhibitors of cyclin D1 and cyclin E using molecular docking and molecular dynamic simulation.
Lokhande KB, Ghosh P, Nagar S, Venkateswara Swamy K.
Mol Divers · journal article · DOI 10.1007/s11030-021-10334-zPhotochemical Pathways of Rotenone and Deguelin Degradation: Implications for Rotenoid Attenuation and Persistence in High-Latitude Lakes.
Redman ZC, Wesolowski J, Tomco PL.
Environ Sci Technol · journal article; research support, n.i.h., extramural · DOI 10.1021/acs.est.1c00129Deguelin targets multiple oncogenic signaling pathways to combat human malignancies.
Tuli HS, Mittal S, Loka M, Aggarwal V, Aggarwal D, Masurkar A, Kaur G, Varol M, Sak K, Kumar M, Sethi G, Bishayee A.
Pharmacol Res · review; journal article · DOI 10.1016/j.phrs.2021.105487Development of a novel truncated deguelin derivative possessing nitric oxide donor as a potential anti-lung cancer agent.
Zhou H, Dong Y, Ma X, Xu J, Xu S.
Fitoterapia · journal article · DOI 10.1016/j.fitote.2020.104670Isolation of the Tephrosia vogelii extract and rotenoids and their toxicity in the RTgill-W1 trout cell line and in zebrafish embryos.
Said AH, Solhaug A, Sandvik M, Msuya FE, Kyewalyanga MS, Mmochi AJ, Lyche JL, Hurem S.
Toxicon · journal article · DOI 10.1016/j.toxicon.2020.05.013Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization.
Gao F, Yu X, Li M, Zhou L, Liu W, Li W, Liu H.
Cell Death Dis · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41419-020-2344-0Deguelin inhibits HCV replication through suppressing cellular autophagy via down regulation of Beclin1 expression in human hepatoma cells.
Liao W, Liu X, Yang Q, Liu H, Liang B, Jiang J, Huang J, Ning C, Zang N, Zhou B, Liao Y, Chen J, Tian L, Ho W, Abdullah AS, Kong L, Liang H, Chen H, Ye L.
Antiviral Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.antiviral.2020.104704Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis.
Li S, Wang Y, Zhao C, Zhang M, Wang W, Yu X, Huang J, Wang Z, Zhu B, Yin C, Cai H.
Iran J Basic Med Sci · research-article; journal article · DOI 10.22038/ijbms.2019.35518.8473HPLC Coupled with Chemometric Analysis and LC-MS Studies of Three Flavonoids in Tephrosia purpurea (L.) Pers Revealed Impact of Chemodiversity on the Quest for the Chemical Markers.
Katakam S, Rathod R, Sharma P, Kachhadiya D, Anandjiwala S, Sharma S, Shrivastava N.
J Chromatogr Sci · journal article · DOI 10.1093/chromsci/bmz058Mitochondrial complex I inhibitor deguelin induces metabolic reprogramming and sensitizes vemurafenib-resistant BRAF<sup>V600E</sup> mutation bearing metastatic melanoma cells.
Carpenter EL, Chagani S, Nelson D, Cassidy PB, Laws M, Ganguli-Indra G, Indra AK.
Mol Carcinog · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1002/mc.23068Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential.
Varughese RS, Lam WS, Marican AABH, Viganeshwari SH, Bhave AS, Syn NL, Wang J, Wong AL, Kumar AP, Lobie PE, Lee SC, Sethi G, Goh BC, Wang L.
Cancer · research support, non-u.s. gov't; review; journal article · DOI 10.1002/cncr.32069MG132 protects against renal dysfunction by regulating Akt-mediated inflammation in diabetic nephropathy.
Zeng W, Qi W, Mu J, Wei Y, Yang LL, Zhang Q, Wu Q, Tang JY, Feng B.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41598-018-38425-2Molecular interaction studies of Deguelin and its derivatives with Cyclin D1 and Cyclin E in cancer cell signaling pathway: The computational approach.
Lokhande KB, Nagar S, Swamy KV.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41598-018-38332-6Inhibition of Cancer Stem-Like Phenotype by Curcumin and Deguelin in CAL-62 Anaplastic Thyroid Cancer Cells.
Kocdor MA, Cengiz H, Ates H, Kocdor H.
Anticancer Agents Med Chem · research support, non-u.s. gov't; journal article · DOI 10.2174/1871520619666191004144025Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway.
Chen L, Jiang K, Chen H, Tang Y, Zhou X, Tan Y, Yuan Y, Xiao Q, Ding K.
Cancer Manag Res · research-article; journal article · DOI 10.2147/cmar.s169476The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts.
Nukui M, O'Connor CM, Murphy EA.
Viruses · research-article; journal article; research support, n.i.h., extramural · DOI 10.3390/v10110614Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells.
Li W, Yu X, Xia Z, Yu X, Xie L, Ma X, Zhou H, Liu L, Wang J, Yang Y, Liu H.
J Cell Mol Med · research support, non-u.s. gov't; research-article; journal article · DOI 10.1111/jcmm.13908Deguelin inhibits RANKL-induced osteoclastogenesis in vitro and prevents inflammation-mediated bone loss in vivo.
Zhang T, Zhao K, Han W, Yang W, Lu X, Liu Q, Li X, Qian Y.
J Cell Physiol · research support, non-u.s. gov't; journal article · DOI 10.1002/jcp.27087Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway.
Li W, Yu X, Ma X, Xie L, Xia Z, Liu L, Yu X, Wang J, Zhou H, Zhou X, Yang Y, Liu H.
Cell Signal · journal article · DOI 10.1016/j.cellsig.2018.07.001Deguelin, a Novel Anti-Tumorigenic Agent in Human Esophageal Squamous Cell Carcinoma.
Baba Y, Kato Y.
EBioMedicine · discussion; journal article · DOI 10.1016/j.ebiom.2017.11.010Deguelin induced differentiation of mutated NPM1 acute myeloid leukemia in vivo and in vitro.
Zhang X, Zhao Z, Yi S, Wen L, He J, Hu J, Ruan J, Fang J, Chen Y.
Anticancer Drugs · journal article · DOI 10.1097/cad.0000000000000494Deguelin and Its Role in Chronic Diseases.
Boyd J, Han A.
Adv Exp Med Biol · review; journal article · DOI 10.1007/978-3-319-41342-6_16Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Udeani GO, Gerhauser C, Thomas CF, Moon RC, Kosmeder JW, Kinghorn AD, Moriarty RM, Pezzuto JM.
Cancer Res · research support, u.s. gov't, p.h.s.; journal article