The Rieske Oxygenase SnoT Catalyzes 2''-Hydroxylation of l-Rhodosamine in Nogalamycin Biosynthesis.
Nji Wandi B, Siitonen V, Palmu K, Metsä-Ketelä M.
Chembiochem · research support, non-u.s. gov't; journal article · DOI 10.1002/cbic.202000229 PUBLICATION REGISTRY
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23 hitsEvolution-guided engineering of non-heme iron enzymes involved in nogalamycin biosynthesis.
Nji Wandi B, Siitonen V, Dinis P, Vukic V, Salminen TA, Metsä-Ketelä M.
FEBS J · research support, non-u.s. gov't; journal article · DOI 10.1111/febs.15192Studies toward the Total Synthesis of Nogalamycin: Construction of the Complete ABCDEF-Ring System via a Convergent Hauser Annulation.
Peng R, VanNieuwenhze MS.
J Org Chem · journal article · DOI 10.1021/acs.joc.8b02602Construction of the DEF-Benzoxocin Ring System of Nogalamycin and Menogaril via a Reductive Heck Cyclization.
Peng R, VanNieuwenhze MS.
J Org Chem · journal article · DOI 10.1021/acs.joc.8b02575Enzymatic Synthesis of the C-Glycosidic Moiety of Nogalamycin R.
Siitonen V, Nji Wandi B, Törmänen AP, Metsä-Ketelä M.
ACS Chem Biol · letter; brief-report; research support, non-u.s. gov't · DOI 10.1021/acschembio.8b00658Discriminating Intercalative Effects of Threading Intercalator Nogalamycin, from Classical Intercalator Daunomycin, Using Single Molecule Atomic Force Spectroscopy.
Banerjee T, Banerjee S, Sett S, Ghosh S, Rakshit T, Mukhopadhyay R.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0154666Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Siitonen V, Selvaraj B, Niiranen L, Lindqvist Y, Schneider G, Metsä-Ketelä M.
Proc Natl Acad Sci U S A · research support, non-u.s. gov't; research-article; journal article · DOI 10.1073/pnas.1525034113[THE ROLE OF STREPTOMYCES NOGALATER Lv65 snoaM, snoaL and snoaE GENES IN NOGALAMYCIN BIOSYNTHESIS].
Klymyshin D, Stephanyshyn O, Fedorenko V.
Tsitol Genet · research support, non-u.s. gov't; journal article; english abstractInactivation and identification of three genes encoding glycosyltransferase required for biosynthesis of nogalamycin.
Shao L, Shi X, Liu W, Gao X, Pu T, Ma B, Wang S.
Biotechnol Appl Biochem · research support, non-u.s. gov't; journal article · DOI 10.1002/bab.1332Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater.
Claesson M, Siitonen V, Dobritzsch D, Metsä-Ketelä M, Schneider G.
FEBS J · research support, non-u.s. gov't; journal article · DOI 10.1111/j.1742-4658.2012.08711.xDiscovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis.
Siitonen V, Blauenburg B, Kallio P, Mäntsälä P, Metsä-Ketelä M.
Chem Biol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.chembiol.2012.04.009Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin.
Siitonen V, Claesson M, Patrikainen P, Aromaa M, Mäntsälä P, Schneider G, Metsä-Ketelä M.
Chembiochem · research support, non-u.s. gov't; journal article · DOI 10.1002/cbic.201100637[Role of the snorA gene in nogalamycin biosynthesis by strain Streptomyces nogalater Lv65 ].
Klimyshin DO, Gren' TP, Fedorenko VO.
Mikrobiologiia · journal article · DOI 10.1134/s0026261711040096Structural effects of nogalamycin, an antibiotic antitumour agent, on DNA.
Banerjee T, Mukhopadhyay R.
Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2008.07.053The intercalation of DNA double helices with doxorubicin and nogalamycin.
Box VG.
J Mol Graph Model · journal article · DOI 10.1016/j.jmgm.2006.09.005Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis.
Sultana A, Kallio P, Jansson A, Niemi J, Mäntsälä P, Schneider G.
Acta Crystallogr D Biol Crystallogr · research support, non-u.s. gov't; journal article · DOI 10.1107/s090744490400705xStructure, dynamics and hydration of the nogalamycin-d(ATGCAT)2Complex determined by NMR and molecular dynamics simulations in solution.
Williams HE, Searle MS.
J Mol Biol · research support, non-u.s. gov't; journal article · DOI 10.1006/jmbi.1999.2903A continuous transition from A-DNA to B-DNA in the 1:1 complex between nogalamycin and the hexamer dCCCGGG.
Cruse WB, Saludjian P, Leroux Y, Léger G, Manouni DE, Prangé T.
J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.271.26.15558DNA-drug refinement: a comparison of the programs NUCLSQ, PROLSQ, SHELXL93 and X-PLOR, using the low-temperature d(TGATCA)-nogalamycin structure.
Schuerman GS, Smith CK, Turkenburg JP, Dettmar AN, Van Meervelt L, Moore MH.
Acta Crystallogr D Biol Crystallogr · journal article · DOI 10.1107/s0907444995012261DNA-nogalamycin interactions: the crystal structure of d(TGATCA) complexed with nogalamycin.
Smith CK, Davies GJ, Dodson EJ, Moore MH.
Biochemistry · research support, non-u.s. gov't; journal article · DOI 10.1021/bi00002a005DNA-nogalamycin interactions.
Egli M, Williams LD, Frederick CA, Rich A.
Biochemistry · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/bi00219a029Binding of the antitumor drug nogalamycin and its derivatives to DNA: structural comparison.
Gao YG, Liaw YC, Robinson H, Wang AH.
Biochemistry · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/bi00497a004Template specificity of DNA binding by nogalamycin and its analogs utilizing competitive fluorescence polarization.
Richardson CL, Grant AD, Schpok SL, Krueger WC, Li LH.
Cancer Res · comparative study; journal article