Effect of s-methyl-L-cysteine on oxidative stress, inflammation and insulin resistance in male wistar rats fed with high fructose diet. ↗
Thomas S, Senthilkumar GP, Sivaraman K, Bobby Z, Paneerselvam S, Harichandrakumar KT.
Vad undersöktes?
- Hur undersöktes det?
- Male Wistar rats were divided into five groups (6 rats in each group), namely; control, control+S-methyl cysteine (SMC), high fructose diet (HFD), HFD+SMC and HFD+metformin. The 60% fructose used for 8 weeks and SMC in the dose of 100 mg/kg bw/day/rat was used in the study.
- Vilka undersöktes?
- Male Wistar rats
- Vilken ämnesform?
- s-methyl-L-cysteine
- Vilken mängd användes?
- 100 mg/kg bw/day/rat
- Hur länge pågick studien?
- 60 days
Studieuppgifterna återges som originalcitat. Uppgifter som saknas här kan finnas i originalutdraget.
Vad kom studien fram till?
Författarna rapporterar att oral administrering av S‑methyl‑L‑cystein (100 mg/kg kroppsvikt per dag) i 60 dagar signifikant minskade plasma‑glukos, insulin, tumor‑nekros‑faktor‑α och insulinresistens samt förbättrade antioxidantenzymaktivitet hos hanar av Wistar‑råttor som fick en högfruktosdiet.
Vad behöver resultatet vägas mot?
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MethodsMale Wistar rats were divided into five groups (6 rats in each group), namely; control, control+S-methyl cysteine (SMC), high fructose diet (HFD), HFD+SMC and HFD+metformin. The 60% fructose used for 8 weeks and SMC in the dose of 100 mg/kg bw/day/rat was used in the study. The fasting glucose, insulin, insulin resistance, and tumor necrosis factor alpha and erythrocyte enzymatic antioxidants were measured.
ResultsIncreased levels of plasma glucose, insulin, malondialdehyde, tumor necrosis factor-alpha, and insulin resistance and decreased levels of glutathione, glutathione peroxidase, and catalase were found in rats on a high fructose diet. Oral administration of SMC (100 mg/kg bw/day/rat) for 60 days resulted in significant attenuation of plasma glucose, insulin, tumor necrosis factor–alpha, insulin resistance and improved antioxidant enzyme activities.
Materials and MethodsGroup 2: Control-s-methyl-L-cysteine (100 mg/kg bw/day/rat) in aqueous solution orally for 60 days.
Materials and MethodsGroup 4: HFD+s-methyl-L-cysteine (100 mg/kg bw/day/rat) in aqueous solution orally for 60 days.
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