Effect of Qmix 2in1, chlorhexidine gluconate, and ethylenediaminetetraacetic acid on postoperative pain after root canal treatment: A double-blind randomized clinical trial. ↗
İnce Yusufoğlu S, Olcay K.
Vad undersöktes?
- Hur undersöktes det?
- prospective, randomized, double-blind clinical trial
- Vilka undersöktes?
- nonvital premolar and molar teeth with periapical lesions (PAI: 3‒4) without any clinical symptoms
- Vilken ämnesform?
- 17% ethylenediaminetetraacetic acid (EDTA)
- Vilken mängd användes?
- 2 mL of 17% ethylenediaminetetraacetic acid (EDTA)
- Hur länge pågick studien?
- for 60 seconds
Studieuppgifterna återges som originalcitat. Uppgifter som saknas här kan finnas i originalutdraget.
Vad kom studien fram till?
Författarna rapporterar att ingen signifikant skillnad i postoperativ smärta observerades för EDTA‑gruppen jämfört med Qmix‑ och CHX‑grupperna vid 12, 48, 72 timmar och en vecka efter behandlingen.
Vad behöver resultatet vägas mot?
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Läs de originalstycken som sammanställningen bygger på
AbstractMethods. Eighty-nine nonvital premolar and molar teeth with periapical lesions (PAI: 3‒4) without any clinical symptoms were included. The patients were randomly assigned to three groups according to the final irrigation solutions used: G1: 2 mL of Qmix (n=29), G2: 2 mL of 17% ethylenediaminetetraacetic acid (EDTA) (n=30), and G3: 2 mL of 2% chlorhexidine gluconate (CHX) (n=30). All the patients were prescribed 100 mg of flurbiprofen to use as needed for pain. The patients were asked to rate their pain status according to the verbal rating scale at 12, 24, 48, and 72 hours, and one week. The data were analyzed using Pearson’s chi-squared test, Fisher’s exact test, and chi-squared analysis with Monte Carlo simulation. The significance level was set at P≤0.05.
AbstractResults. No significant differences were observed in postoperative pain rates at 12, 48, and 72 hours and one week (P>0.05). However, in the Qmix group, a significantly lower pain level was observed at 24 hours with EDTA and CHX (P=0.019). The rate of mild pain in the EDTA group at 72 hours (18.8%) was significantly higher in premolar teeth than in molar teeth (P=0.012). The moderate pain level in the EDTA group at 12 hours was significantly higher in those>60 years of age (P=0.008).
Patient selectionThe method and design of this prospective, randomized, double-blind clinical trial were approved by the Ethics Board of the University (No: 929). The study protocol was published and registered at www.clinicaltrials.gov (identifier: ). Before inclusion, all the patients were informed of the study protocol, aims, complications, and possible risks, and written informed consent was obtained from each patient. Patients who met the inclusion criteria were treated by a single endodontist (SIY) from the Faculty of Dentistry, Department of Endodontics, between October 2019 and February 2020.
Root canal treatment proceduresGroup 2 (EDTA, n = 30): After applying 2 mL of saline solution to each root canal for 30 sec, 2 mL of 17% EDTA was applied for 60 seconds.
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