Ethosuximide and phenobarbital promote wound healing via enhancing collagenization.
Ajwee DM, Disi AM, Qunaibi EA, Taha MO.
Chem Biol Drug Des · letter; research support, non-u.s. gov't · DOI 10.1111/j.1747-0285.2011.01105.x PUBLICATION REGISTRY
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22 hitsEthosuximide modifies network excitability in the rat entorhinal cortex via an increase in GABA release.
Greenhill SD, Morgan NH, Massey PV, Woodhall GL, Jones RS.
Neuropharmacology · research support, non-u.s. gov't; journal article · DOI 10.1016/j.neuropharm.2011.09.006Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions.
Wang G, Thompson SM.
J Neurosci · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1523/jneurosci.3296-08.2008The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan.
Collins JJ, Evason K, Pickett CL, Schneider DL, Kornfeld K.
PLoS Genet · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1371/journal.pgen.1000230Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Yogeeswari P, Ragavendran JV, Sriram D, Nageswari Y, Kavya R, Sreevatsan N, Vanitha K, Stables J.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm061431gSynthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach.
Yogeeswari P, Sriram D, Sahitya P, Ragavendran JV, Ranganadh V.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2007.04.032Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain.
Siddiqui N, Pandeya SN, Khan SA, Stables J, Rana A, Alam M, Arshad MF, Bhat MA.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.09.053Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.
Ragavendran JV, Sriram D, Patel SK, Reddy IV, Bharathwajan N, Stables J, Yogeeswari P.
Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2006.08.010Effects of anticonvulsant drugs on life span.
Kornfeld K, Evason K.
Arch Neurol · research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1001/archneur.63.4.491Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Bruno-Blanch L, Gálvez J, García-Domenech R.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00535-3Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams).
Reddy PA, Woodward KE, McIlheran SM, Hsiang BC, Latifi TN, Hill MW, Rothman SM, Ferrendelli JA, Covey DF.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm960561u3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents.
Reddy PA, Hsiang BC, Latifi TN, Hill MW, Woodward KE, Rothman SM, Ferrendelli JA, Covey DF.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm9600196Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.
Flaherty PT, Greenwood TD, Manheim AL, Wolfe JF.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm950761qSynthesis and CLOGP correlation of imidooxy anticonvulsants.
Farrar VA, Ciechanowicz-Rutkowska M, Grochowski J, Serda P, Pilati T, Filippini G, Hinko CN, el-Assadi A, Moore JA, Edafiogho IO.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00075a0052-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Tomczuk BE, Taylor CR, Moses LM, Sutherland DB, Lo YS, Johnson DN, Kinnier WB, Kilpatrick BF.
J Med Chem · journal article · DOI 10.1021/jm00114a007Synthesis and anticonvulsant activity of 2-iminohydantoins.
Kwon CH, Iqbal MT, Wurpel JN.
J Med Chem · journal article · DOI 10.1021/jm00110a013Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives.
Sasaki H, Mori Y, Nakamura J, Shibasaki J.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00106a025Synthesis and anticonvulsant activity of imidooxy derivatives.
Edafiogho IO, Scott KR, Moore JA, Farrar VA, Nicholson JM.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00105a059Synthesis and anticonvulsant activity of 2-benzylglutarimides.
Goehring RR, Greenwood TD, Nwokogu GC, Pisipati JS, Rogers TG, Wolfe JF.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00165a007Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Wolfe JF, Rathman TL, Sleevi MC, Campbell JA, Greenwood TD.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00163a027Triazolines. 14. 1,2,3-Triazolines and triazoles, a new class of anticonvulsants. Drug design and structure-activity relationships.
Kadaba PK.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00396a032Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
Conley JD, Kohn H.
J Med Chem · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00386a021