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Publikationer som ChEBI hänvisar till för AZD7545. Visa hela publikationsregistret

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Publications in the selection

12 hits

Bibliografisk träff 2020-11-28

PDK2 Deficiency Prevents Ovariectomy-Induced Bone Loss in Mice by Regulating the RANKL-NFATc1 Pathway During Osteoclastogenesis.

Lee JM, Kim MJ, Lee SJ, Kim BG, Choi JY, Lee SM, Ham HJ, Koh JM, Jeon JH, Lee IK.

J Bone Miner Res · research support, non-u.s. gov't; journal article · DOI 10.1002/jbmr.4202

Bibliografisk träff 2019-09-03

In vitro cytotoxicity screening to identify novel anti-osteosarcoma therapeutics targeting pyruvate dehydrogenase kinase 2.

Cao W, Wang Z, Han X, Liu J, Wang W.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2019.126665

Bibliografisk träff 2018-12-24

High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.

Wu DM, Wang YJ, Fan SH, Zhang ZF, Shan Q, Lu J, Chen GQ, Zheng YL.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.12.051

Bibliografisk träff 2018-07-31

Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors.

Zhang W, Hu X, Zhou W, Tam KY.

J Proteome Res · research support, non-u.s. gov't; validation study; journal article · DOI 10.1021/acs.jproteome.8b00184

Bibliografisk träff 2017-06-08

ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells.

Cesi G, Walbrecq G, Zimmer A, Kreis S, Haan C.

Mol Cancer · research-article; journal article · DOI 10.1186/s12943-017-0667-y

Bibliografisk träff 2017-02-15

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.

Brough PA, Baker L, Bedford S, Brown K, Chavda S, Chell V, D'Alessandro J, Davies NG, Davis B, Le Strat L, Macias AT, Maddox D, Mahon PC, Massey AJ, Matassova N, McKenna S, Meissner JW, Moore JD, Murray JB, Northfield CJ, Parry C, Parsons R, Roughley SD, Shaw T, Simmonite H, Stokes S, Surgenor A, Stefaniak E, Robertson A, Wang Y, Webb P, Whitehead N, Wood M.

J Med Chem · journal article · DOI 10.1021/acs.jmedchem.6b01478

Bibliografisk träff 2016-10-19

Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism.

Makita N, Ishiguro J, Suzuki K, Nara F.

J Pharm Pharmacol · journal article · DOI 10.1111/jphp.12655

Bibliografisk träff 2008-07-24

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity.

Wynn RM, Kato M, Chuang JL, Tso SC, Li J, Chuang DT.

J Biol Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1074/jbc.m802249200

Bibliografisk träff 2007-08-02

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

Kato M, Li J, Chuang JL, Chuang DT.

Structure · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.str.2007.07.001

Bibliografisk träff 2007-06-30

Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2.

Tuganova A, Klyuyeva A, Popov KM.

Biochemistry · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/bi700650k

Bibliografisk träff 2003-12-01

AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats.

Mayers RM, Butlin RJ, Kilgour E, Leighton B, Martin D, Myatt J, Orme JP, Holloway BR.

Biochem Soc Trans · review; journal article · DOI 10.1042/bst0311165

Bibliografisk träff 2003-12-01

AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2.

Morrell JA, Orme J, Butlin RJ, Roche TE, Mayers RM, Kilgour E.

Biochem Soc Trans · journal article · DOI 10.1042/bst0311168