Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii.
Mout R, Xu ZD, Wolf AK, Jo Davisson V, Jarori GK.
Malar J · research-article; journal article · DOI 10.1186/1475-2875-11-54 PUBLICATION REGISTRY
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8 hitsHsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics.
Haupt A, Joberty G, Bantscheff M, Fröhlich H, Stehr H, Schweiger MR, Fischer A, Kerick M, Boerno ST, Dahl A, Lappe M, Lehrach H, Gonzalez C, Drewes G, Lange BM.
BMC Cancer · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/1471-2407-12-38Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.
Eichner S, Eichner T, Floss HG, Fohrer J, Hofer E, Sasse F, Zeilinger C, Kirschning A.
J Am Chem Soc · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/ja2087147Hsp90 molecular chaperone inhibitors: are we there yet?
Neckers L, Workman P.
Clin Cancer Res · research support, n.i.h., intramural; research support, non-u.s. gov't; research-article; review; journal article · DOI 10.1158/1078-0432.ccr-11-1000Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins.
McNamara AV, Barclay M, Watson AJ, Jenkins JR.
Biochem Pharmacol · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bcp.2011.11.017RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons.
Chen WW, Yu H, Fan HB, Zhang CC, Zhang M, Zhang C, Cheng Y, Kong J, Liu CF, Geng D, Xu X.
J Neurochem · research support, non-u.s. gov't; journal article · DOI 10.1111/j.1471-4159.2011.07526.xUBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition.
Sultana R, Theodoraki MA, Caplan AJ.
Exp Cell Res · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.yexcr.2011.09.010Geldanamycin is effective in the treatment of herpes simplex virus epithelial keratitis in a rabbit model.
Wu X, Tao P, Nie H.
Clin Exp Ophthalmol · comparative study; journal article · DOI 10.1111/j.1442-9071.2011.02558.x