Purmorphamine and oxysterols accelerate and promote osteogenic differentiation of mesenchymal stem cells in vitro.
Wöltje M, Böbel M, Heiland M, Beck-Broichsitter B, Al-Dam A, Gröbe A, Friedrich RE, Hanken H, Smeets R.
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10 hitsA Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury.
Chechneva OV, Mayrhofer F, Daugherty DJ, Krishnamurty RG, Bannerman P, Pleasure DE, Deng W.
Cell Death Dis · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/cddis.2014.446The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Faghihi F, Baghaban Eslaminejad M, Nekookar A, Najar M, Salekdeh GH.
Biomed Pharmacother · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.biopha.2012.10.004Virtual ligand-based screening reveals purmorphamine analogs with the capacity to induce the osteogenic differentiation of human mesenchymal stem cells.
Granéli C, Karlsson C, Lindahl A, Thomsen P.
Cells Tissues Organs · research support, non-u.s. gov't; journal article · DOI 10.1159/000342796Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells.
Oliveira FS, Bellesini LS, Defino HL, da Silva Herrero CF, Beloti MM, Rosa AL.
J Cell Biochem · research support, non-u.s. gov't; journal article · DOI 10.1002/jcb.23345Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway.
El-Akabawy G, Medina LM, Jeffries A, Price J, Modo M.
Stem Cells Dev · research support, non-u.s. gov't; journal article · DOI 10.1089/scd.2010.0282Cell attachment and response to photocured, degradable bone adhesives containing tricalcium phosphate and purmorphamine.
Gellynck K, Neel EA, Li H, Mardas N, Donos N, Buxton P, Young AM.
Acta Biomater · research support, non-u.s. gov't; journal article · DOI 10.1016/j.actbio.2011.02.033Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
Sinha S, Chen JK.
Nat Chem Biol · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1038/nchembio753Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells.
Beloti MM, Bellesini LS, Rosa AL.
Cell Biol Int · journal article · DOI 10.1016/j.cellbi.2005.02.007A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
Wu X, Ding S, Ding Q, Gray NS, Schultz PG.
J Am Chem Soc · research support, non-u.s. gov't; journal article · DOI 10.1021/ja0283908