Exendin-4 ameliorates diabetic symptoms through activation of glucokinase.
Dhanesha N, Joharapurkar A, Shah G, Shah G, Dhote V, Kshirsagar S, Bahekar R, Jain M.
J Diabetes · journal article · DOI 10.1111/j.1753-0407.2012.00193.x PUBLICATION REGISTRY
Go to research.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för exendin-4. Visa hela publikationsregistret
A publication hit is not a conclusion. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publications in the selection
13 hitsExendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis.
Li Y, Chigurupati S, Holloway HW, Mughal M, Tweedie D, Bruestle DA, Mattson MP, Wang Y, Harvey BK, Ray B, Lahiri DK, Greig NH.
PLoS One · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1371/journal.pone.0032008Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice.
Lee J, Hong SW, Chae SW, Kim DH, Choi JH, Bae JC, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Kim SW, Lee WY.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0031394Target-mediated pharmacokinetic and pharmacodynamic model of exendin-4 in rats, monkeys, and humans.
Gao W, Jusko WJ.
Drug Metab Dispos · research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/dmd.111.042291Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro.
Dalvi PS, Nazarians-Armavil A, Purser MJ, Belsham DD.
Endocrinology · research support, non-u.s. gov't; journal article · DOI 10.1210/en.2011-1795Additive feeding inhibitory and aversive effects of naltrexone and exendin-4 combinations.
Liang NC, Bello NT, Moran TH.
Int J Obes (Lond) · research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/ijo.2012.16Sensitivity to the satiating effects of exendin 4 is decreased in obesity-prone Osborne-Mendel rats compared to obesity-resistant S5B/Pl rats.
Primeaux SD, Barnes MJ, Braymer HD, Bray GA.
Int J Obes (Lond) · research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/ijo.2010.78Long acting hyaluronate--exendin 4 conjugate for the treatment of type 2 diabetes.
Kong JH, Oh EJ, Chae SY, Lee KC, Hahn SK.
Biomaterials · research support, non-u.s. gov't; journal article · DOI 10.1016/j.biomaterials.2010.01.091Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
Alarcon C, Wicksteed B, Rhodes CJ.
Diabetologia · journal article; research support, n.i.h., extramural · DOI 10.1007/s00125-006-0433-yGrowth restriction and exendin 4 promote endocrine expression in cultured islet cells derived from patients with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Webb M, James RF.
Endocr Res · research support, non-u.s. gov't; journal article · DOI 10.1080/07435800500229235Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.
MacDonald PE, Wang X, Xia F, El-kholy W, Targonsky ED, Tsushima RG, Wheeler MB.
J Biol Chem · research support, non-u.s. gov't; journal article · DOI 10.1074/jbc.m307612200Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells.
Movassat J, Beattie GM, Lopez AD, Hayek A.
J Clin Endocrinol Metab · research support, non-u.s. gov't; journal article · DOI 10.1210/jc.2002-020137Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.
Eng J, Kleinman WA, Singh L, Singh G, Raufman JP.
J Biol Chem · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/s0021-9258(18)42531-8