7-ketocholesterol induces apoptosis in differentiated PC12 cells via reactive oxygen species-dependent activation of NF-κB and Akt pathways.
Jang ER, Lee CS.
Neurochem Int · journal article · DOI 10.1016/j.neuint.2010.10.012 PUBLICATION REGISTRY
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17 hits7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation.
Larrayoz IM, Huang JD, Lee JW, Pascual I, Rodríguez IR.
Invest Ophthalmol Vis Sci · research support, n.i.h., intramural; research-article; journal article · DOI 10.1167/iovs.09-4854Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes.
Mintzer E, Charles G, Gordon S.
Chem Phys Lipids · journal article · DOI 10.1016/j.chemphyslip.2010.05.0017-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways.
Liao PL, Cheng YW, Li CH, Wang YT, Kang JJ.
Toxicol Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.toxlet.2010.05.002Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells.
Kahn E, Baarine M, Pelloux S, Riedinger JM, Frouin F, Tourneur Y, Lizard G.
Int J Nanomedicine · research support, non-u.s. gov't; research-article; journal article · DOI 10.2147/ijn.s84587-ketocholesterol induces cell apoptosis by activation of nuclear factor kappa B in mouse macrophages.
Huang Z, Liu Q, Li W, Wang R, Wang D, Zhang Y, Zhang F, Chi Y, Liu Z, Matsuura E, Liu Z, Zhang Q.
Acta Med Okayama · research support, non-u.s. gov't; journal article · DOI 10.18926/amo/32848Analysis of the capture and influence of nanoparticles on the cytotoxic effects of 7-ketocholesterol on cardiac cells: investigation by flow cytometry and by dynamic and spectral imaging microscopy associated with factor analysis of medical image sequences.
Kahn E, Pelloux S, Baarine M, Khalfaoui T, Ragot K, Frouin F, Riedinger JM, Tourneur Y, Lizard G.
Anal Quant Cytol Histol · research support, non-u.s. gov't; journal article7-ketocholesterol catabolism by Rhodococcus jostii RHA1.
Mathieu JM, Mohn WW, Eltis LD, LeBlanc JC, Stewart GR, Dresen C, Okamoto K, Alvarez PJ.
Appl Environ Microbiol · comparative study; research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aem.02538-09Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro.
Gramajo AL, Zacharias LC, Neekhra A, Luthra S, Atilano SR, Chwa M, Brown DJ, Kuppermann BD, Kenney MC.
Invest Ophthalmol Vis Sci · research support, non-u.s. gov't; journal article · DOI 10.1167/iovs.09-3443Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol.
Liu J, Netherland C, Pickle T, Sinensky MS, Thewke DP.
Arch Biochem Biophys · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.abb.2009.05.0047-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death.
Royer MC, Lemaire-Ewing S, Desrumaux C, Monier S, Pais de Barros JP, Athias A, Néel D, Lagrost L.
J Biol Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1074/jbc.m808641200Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury.
He X, Jittiwat J, Kim JH, Jenner AM, Farooqui AA, Patel SC, Ong WY.
Neurosci Lett · brief-report; research support, non-u.s. gov't; journal article · DOI 10.1016/j.neulet.2009.03.0387-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation.
Moreira EF, Larrayoz IM, Lee JW, Rodríguez IR.
Invest Ophthalmol Vis Sci · research support, n.i.h., intramural; research-article; journal article · DOI 10.1167/iovs.08-23737-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells.
Saito E, Wachi H, Sato F, Seyama Y.
J Atheroscler Thromb · journal article · DOI 10.5551/jat.e556Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.
Vejux A, Guyot S, Montange T, Riedinger JM, Kahn E, Lizard G.
J Nutr Biochem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.jnutbio.2007.12.001Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells.
Martinet W, Schrijvers DM, Timmermans JP, Bult H.
Br J Pharmacol · other; research support, non-u.s. gov't; journal article · DOI 10.1038/bjp.2008.181High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1.
Terasaka N, Wang N, Yvan-Charvet L, Tall AR.
Proc Natl Acad Sci U S A · research-article; journal article; research support, n.i.h., extramural · DOI 10.1073/pnas.0704602104