A physiologically based pharmacokinetic model of alvespimycin in mice and extrapolation to rats and humans.
Hu ZY, Lu J, Zhao Y.
Br J Pharmacol · research-article; journal article · DOI 10.1111/bph.12609 PUBLICATION REGISTRY
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11 hitsDiscovery of the neuroprotective effects of alvespimycin by computational prioritization of potential anti-Parkinson agents.
Gao L, Zhao G, Fang JS, Yuan TY, Liu AL, Du GH.
FEBS J · research support, non-u.s. gov't; journal article · DOI 10.1111/febs.12672The growth inhibitory effect of 17-DMAG on ALK and MYCN double-positive neuroblastoma cell line.
Yi B, Yang J, Wang L.
Tumour Biol · journal article · DOI 10.1007/s13277-013-1422-7Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells.
Sun X, Bristol JA, Iwahori S, Hagemeier SR, Meng Q, Barlow EA, Fingeroth JD, Tarakanova VL, Kalejta RF, Kenney SC.
J Virol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/jvi.01671-13Combined effects of 17-DMAG and TNF on cells through a mechanism related to the NF-kappaB pathway.
Qu Z, Dong H, Xu X, Feng W, Yi X.
Diagn Pathol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/1746-1596-8-70The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells.
Leng AM, Liu T, Yang J, Cui JF, Li XH, Zhu YN, Xiong T, Zhang G, Chen Y.
Cell Biol Int · research support, non-u.s. gov't; journal article · DOI 10.1042/cbi20110473HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis.
Madrigal-Matute J, Fernandez-Garcia CE, Gomez-Guerrero C, Lopez-Franco O, Muñoz-Garcia B, Egido J, Blanco-Colio LM, Martin-Ventura JL.
Cardiovasc Res · research support, non-u.s. gov't; journal article · DOI 10.1093/cvr/cvs158One-electron reduction of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: a pulse radiolysis study.
Goldstein S.
J Phys Chem A · research support, non-u.s. gov't; journal article · DOI 10.1021/jp205161vGeldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation.
Fukumoto R, Kiang JG.
Radiat Res · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1667/rr2534.1A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors.
Pacey S, Wilson RH, Walton M, Eatock MM, Hardcastle A, Zetterlund A, Arkenau HT, Moreno-Farre J, Banerji U, Roels B, Peachey H, Aherne W, de Bono JS, Raynaud F, Workman P, Judson I.
Clin Cancer Res · research support, non-u.s. gov't; research-article; clinical trial, phase i; journal article · DOI 10.1158/1078-0432.ccr-10-1927Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis.
Wu YC, Yen WY, Lee TC, Yih LH.
Toxicol Appl Pharmacol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.taap.2009.02.003