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Publications in the selection

50 hits

Bibliografisk träff 2009-11-01

Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.

Huang Q, Mao J, Wan B, Wang Y, Brun R, Franzblau SG, Kozikowski AP.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm901112f

Bibliografisk träff 2009-09-03

Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.

Van Baelen G, Hostyn S, Dhooghe L, Tapolcsányi P, Mátyus P, Lemière G, Dommisse R, Kaiser M, Brun R, Cos P, Maes L, Hajós G, Riedl Z, Nagy I, Maes BU, Pieters L.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.08.057

Bibliografisk träff 2009-09-01

On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.

Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J, Rosenthal PJ, Kisker C, Leyh M, Schmuck C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm900629w

Bibliografisk träff 2009-08-01

Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine.

Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm900805v

Bibliografisk träff 2009-07-20

New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.

Wenzler T, Boykin DW, Ismail MA, Hall JE, Tidwell RR, Brun R.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00225-09

Bibliografisk träff 2009-06-29

Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives.

Dardonville C, Fernández-Fernández C, Gibbons SL, Jagerovic N, Nieto L, Ryan G, Kaiser M, Brun R.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00124-09

Bibliografisk träff 2009-04-20

Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.

Cavalli A, Lizzi F, Bongarzone S, Brun R, Luise Krauth-Siegel R, Bolognesi ML.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2009.04.060

Bibliografisk träff 2009-04-13

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.

Holloway GA, Charman WN, Fairlamb AH, Brun R, Kaiser M, Kostewicz E, Novello PM, Parisot JP, Richardson J, Street IP, Watson KG, Baell JB.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.01568-08

Bibliografisk träff 2009-04-07

Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids.

Faist J, Seebacher W, Schlapper C, Kaiser M, Brun R, Saf R, Weis R.

Bioorg Med Chem · journal article · DOI 10.1016/j.bmc.2009.04.002

Bibliografisk träff 2009-04-01

Structure-activity study of pentamidine analogues as antiprotozoal agents.

Bakunova SM, Bakunov SA, Patrick DA, Kumar EV, Ohemeng KA, Bridges AS, Wenzler T, Barszcz T, Jones SK, Werbovetz KA, Brun R, Tidwell RR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm801547t

Bibliografisk träff 2008-10-09

Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans.

Bakunov SA, Bakunova SM, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Tidwell RR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800918v

Bibliografisk träff 2008-08-07

Antiprotozoal activities of heterocyclic-substituted xanthones from the marine-derived fungus Chaetomium sp.

Pontius A, Krick A, Kehraus S, Brun R, König GM.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np800294q

Bibliografisk träff 2008-05-14

Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives.

Ge JF, Arai C, Kaiser M, Wittlin S, Brun R, Ihara M.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm8003619

Bibliografisk träff 2008-05-10

Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates.

Schlapper C, Seebacher W, Faist J, Kaiser M, Brun R, Saf R, Weis R.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2008.05.002

Bibliografisk träff 2008-05-07

Novel azabicyclo[3.2.2]nonane derivatives and their activities against Plasmodium falciparum K1 and Trypanosoma brucei rhodesiense.

Berger H, Weis R, Kaiser M, Brun R, Saf R, Seebacher W.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.05.007

Bibliografisk träff 2008-03-07

Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.

Bolognesi ML, Lizzi F, Perozzo R, Brun R, Cavalli A.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2008.03.009

Bibliografisk träff 2008-02-05

New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.

Rodríguez F, Rozas I, Kaiser M, Brun R, Nguyen B, Wilson WD, García RN, Dardonville C.

J Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/jm7013088

Bibliografisk träff 2007-10-20

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.

Kuettel S, Zambon A, Kaiser M, Brun R, Scapozza L, Perozzo R.

J Med Chem · journal article · DOI 10.1021/jm700938n

Bibliografisk träff 2007-10-19

Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations.

Bakunova SM, Bakunov SA, Wenzler T, Barszcz T, Werbovetz KA, Brun R, Hall JE, Tidwell RR.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0708634

Bibliografisk träff 2007-10-09

Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii.

Senn M, Gunzenhauser S, Brun R, Séquin U.

J Nat Prod · research support, non-u.s. gov't; journal article · DOI 10.1021/np0702133

Bibliografisk träff 2007-08-22

Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.

Tasdemir D, Topaloglu B, Perozzo R, Brun R, O'Neill R, Carballeira NM, Zhang X, Tonge PJ, Linden A, Rüedi P.

Bioorg Med Chem · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2007.07.032

Bibliografisk träff 2007-08-13

2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.

Rodenko B, van der Burg AM, Wanner MJ, Kaiser M, Brun R, Gould M, de Koning HP, Koomen GJ.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00425-07

Bibliografisk träff 2007-07-05

Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity.

Schlapper C, Seebacher W, Kaiser M, Brun R, Saf R, Weis R.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2007.06.007

Bibliografisk träff 2007-06-11

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

Kaiser M, Wittlin S, Nehrbass-Stuedli A, Dong Y, Wang X, Hemphill A, Matile H, Brun R, Vennerstrom JL.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00225-07

Bibliografisk träff 2007-05-23

Bicyclo[2.2.2]octyl esters of dialkylamino acids as antiprotozoals.

Schlapper C, Seebacher W, Kaiser M, Brun R, Saf R, Weis R.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.05.042

Bibliografisk träff 2007-04-18

Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.

Patrick DA, Bakunov SA, Bakunova SM, Kumar EV, Lombardy RJ, Jones SK, Bridges AS, Zhirnov O, Hall JE, Wenzler T, Brun R, Tidwell RR.

J Med Chem · journal article · DOI 10.1021/jm0612867

Bibliografisk träff 2007-03-19

Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.

Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1128/aac.01418-06

Bibliografisk träff 2007-01-01

Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi.

Hay AE, Ioset JR, Ahua KM, Diallo D, Brun R, Hostettmann K.

J Nat Prod · journal article · DOI 10.1021/np0680230

Bibliografisk träff 2006-08-02

Antiprotozoal activities of new bis-chlorophenyl derivatives of bicyclic octanes and aza-nonanes.

Berger H, Seebacher W, Saf R, Kaiser M, Brun R, Weis R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.07.057

Bibliografisk träff 2006-03-03

Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.

Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.02.026