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Publikationer som ChEBI hänvisar till för sjg-136. Visa hela publikationsregistret

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Publications in the selection

9 hits

Bibliografisk träff 2009-09-09

Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.

Howard PW, Chen Z, Gregson SJ, Masterson LA, Tiberghien AC, Cooper N, Fang M, Coffils MJ, Klee S, Hartley JA, Thurston DE.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2009.09.012

Bibliografisk träff 2009-01-06

Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential.

Kamal A, Rajender, Reddy DR, Reddy MK, Balakishan G, Shaik TB, Chourasia M, Sastry GN.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.12.068

Bibliografisk träff 2008-01-30

An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.

Tiberghien AC, Evans DA, Kiakos K, Martin CR, Hartley JA, Thurston DE, Howard PW.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2008.01.096

Bibliografisk träff 2006-09-01

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.

Wells G, Martin CR, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm051199z

Bibliografisk träff 2006-08-21

DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).

Purnell B, Sato A, O'kelley A, Price C, Summerville K, Hudson S, O'hare C, Kiakos K, Asao T, Lee M, Hartley JA.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2006.08.005

Bibliografisk träff 2004-11-01

Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential.

Kamal A, Reddy PS, Reddy DR, Laxman E, Murthy YL.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.08.050

Bibliografisk träff 2004-02-01

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm030897l

Bibliografisk träff 2001-11-01

Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.

Gregson SJ, Howard PW, Corcoran KE, Jenkins TC, Kelland LR, Thurston DE.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(01)00560-1

Bibliografisk träff 2001-03-01

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.

Gregson SJ, Howard PW, Hartley JA, Brooks NA, Adams LJ, Jenkins TC, Kelland LR, Thurston DE.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm001064n