Recent two-year advances in anti-dengue small-molecule inhibitors.
Yang C, Xie W, Zhang H, Xie W, Tian T, Qin Z.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114753 PUBLICATION REGISTRY
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19 hitsSilybins are stereospecific regulators of the 20S proteasome.
Persico M, García-Viñuales S, Santoro AM, Lanza V, Tundo GR, Sbardella D, Coletta M, Romanucci V, Zarrelli A, Di Fabio G, Fattorusso C, Milardi D.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2022.116813Investigation on the solid-phase synthesis of silybin prodrugs and their timed-release.
Romanucci V, Giordano M, Pagano R, Zimbone S, Giuffrida ML, Milardi D, Zarrelli A, Di Fabio G.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2021.116478Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2.
Wang JP, Li TZ, Huang XY, Geng CA, Shen C, Sun JJ, Xue D, Chen JJ.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2021.127994Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains.
McConnell JR, Dyson HJ, McAlpine SR.
RSC Med Chem · research-article; journal article · DOI 10.1039/d0md00387eUnraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
Zima V, Radilová K, Kožíšek M, Albiñana CB, Karlukova E, Brynda J, Fanfrlík J, Flieger M, Hodek J, Weber J, Majer P, Konvalinka J, Machara A.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.1127541,4-Benzodioxane Lignans: An Efficient, Asymmetric Synthesis of Flavonolignans and Study of Neolignan Cytotoxicity and Antiviral Profiles.
Pilkington LI, Wagoner J, Kline T, Polyak SJ, Barker D.
J Nat Prod · research support, non-u.s. gov't; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jnatprod.8b00416Hepatoprotective natural triterpenoids.
Xu GB, Xiao YH, Zhang QY, Zhou M, Liao SG.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2018.01.011Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive - Based, natural product lead optimization approach.
Manivannan E, Amawi H, Hussein N, Karthikeyan C, Fetcenko A, Narayana Moorthy NSH, Trivedi P, Tiwari AK, Tiwari AK.
Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2017.03.033Silychristin: Skeletal Alterations and Biological Activities.
Biedermann D, Buchta M, Holečková V, Sedlák D, Valentová K, Cvačka J, Bednárová L, Křenková A, Kuzma M, Škuta C, Peikerová Ž, Bartůněk P, Křen V.
J Nat Prod · journal article · DOI 10.1021/acs.jnatprod.6b00750Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer - A comprehensive review.
Polachi N, Bai G, Li T, Chu Y, Wang X, Li S, Gu N, Wu J, Li W, Zhang Y, Zhou S, Sun H, Liu C.
Eur J Med Chem · review; journal article · DOI 10.1016/j.ejmech.2016.07.070Anticancer agents interacting with membrane glucose transporters.
Granchi C, Fortunato S, Minutolo F.
Medchemcomm · research-article; journal article · DOI 10.1039/c6md00287kDevelopment of Safe and Effective Botanical Dietary Supplements.
van Breemen RB.
J Med Chem · research support, non-u.s. gov't; review-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.5b00417Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma.
Pferschy-Wenzig EM, Atanasov AG, Malainer C, Noha SM, Kunert O, Schuster D, Heiss EH, Oberlies NH, Wagner H, Bauer R, Dirsch VM.
J Nat Prod · research support, non-u.s. gov't; review-article; journal article; research support, n.i.h., extramural · DOI 10.1021/np400943bSemisynthesis, cytotoxicity, antiviral activity, and drug interaction liability of 7-O-methylated analogues of flavonolignans from milk thistle.
Althagafy HS, Graf TN, Sy-Cordero AA, Gufford BT, Paine MF, Wagoner J, Polyak SJ, Croatt MP, Oberlies NH.
Bioorg Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmc.2013.04.017Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Köck K, Xie Y, Hawke RL, Oberlies NH, Brouwer KL.
Drug Metab Dispos · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1124/dmd.112.048272Synthesis and antiangiogenic activity of new silybin galloyl esters.
Gažák R, Valentová K, Fuksová K, Marhol P, Kuzma M, Medina MÁ, Oborná I, Ulrichová J, Křen V.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm201034hMelanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.
Nakashima S, Matsuda H, Oda Y, Nakamura S, Xu F, Yoshikawa M.
Bioorg Med Chem · research support, non-u.s. gov't; corrected and republished article; journal article · DOI 10.1016/j.bmc.2010.01.046Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships.
Guz NR, Stermitz FR, Johnson JB, Beeson TD, Willen S, Hsiang J, Lewis K.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm0004190