Picropodophyllin inhibits the growth of Ewing's sarcoma cells through the insulin‑like growth factor‑1 receptor/Akt signaling pathway.
Wu YT, Wang BJ, Miao SW, Gao JJ.
Mol Med Rep · journal article · DOI 10.3892/mmr.2015.4266 PUBLICATION REGISTRY
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22 hitsPicropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cells.
Strömberg T, Feng X, Delforoush M, Berglund M, Lin Y, Axelson M, Larsson O, Georgii-Hemming P, Lennartsson J, Enblad G.
Med Oncol · research support, non-u.s. gov't; journal article · DOI 10.1007/s12032-015-0630-yTargeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention.
Zhang Q, Pan J, Lubet RA, Wang Y, You M.
Mol Carcinog · journal article · DOI 10.1002/mc.22206Abnormal expression of insulin-like growth factor-I receptor in hepatoma tissue and its inhibition to promote apoptosis of tumor cells.
Dong Z, Yao M, Wang L, Yan X, Gu X, Shi Y, Yao N, Qiu L, Wu W, Yao D.
Tumour Biol · research support, non-u.s. gov't; journal article · DOI 10.1007/s13277-013-0912-yThe association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin.
Wang Q, Wei F, Lv G, Li C, Liu T, Hadjipanayis CG, Zhang G, Hao C, Bellail AC.
BMC Cancer · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1186/1471-2407-13-521Heterogeneity of neuroblastoma cell lines in insulin-like growth factor 1 receptor/Akt pathway-mediated cell proliferative responses.
Qi L, Toyoda H, Shankar V, Sakurai N, Amano K, Kihira K, Iwasa T, Deguchi T, Hori H, Azuma E, Gabazza EC, Komada Y.
Cancer Sci · research-article; journal article · DOI 10.1111/cas.12204Alternative cytotoxic effects of the postulated IGF-IR inhibitor picropodophyllin in vitro.
Wu X, Sooman L, Wickström M, Fryknäs M, Dyrager C, Lennartsson J, Gullbo J.
Mol Cancer Ther · research support, non-u.s. gov't; journal article · DOI 10.1158/1535-7163.mct-13-0091Picropodophyllin inhibits epithelial ovarian cancer cells in vitro and in vivo.
Lu X, Wang L, Mei J, Wang X, Zhu X, Zhang Q, Lv J.
Biochem Biophys Res Commun · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bbrc.2013.04.097Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT).
Shim KW, Xi G, Farnell BM, Kim DS, Tsurubuchi T, Tomita T, Mayanil CS.
Childs Nerv Syst · research support, non-u.s. gov't; journal article · DOI 10.1007/s00381-013-2087-7Investigating new therapeutic strategies targeting hyperinsulinemia's mitogenic effects in a female mouse breast cancer model.
Rostoker R, Bitton-Worms K, Caspi A, Shen-Orr Z, LeRoith D.
Endocrinology · research support, non-u.s. gov't; evaluation study; journal article · DOI 10.1210/en.2012-2263The insulin-like growth factor-I receptor inhibitor picropodophyllin-induced selective apoptosis of hepatocellular carcinoma cell through a caspase-dependent mitochondrial pathway.
E C, Li J, Shao D, Zhang D, Pan Y, Chen L, Zhang X.
Oncol Res · research support, non-u.s. gov't; journal article · DOI 10.3727/096504013x13808175127324Effects of epidermal growth factor receptor and insulin-like growth factor 1 receptor inhibition on proliferation and intracellular signaling in cutaneous SCCHN: potential for dual inhibition as a therapeutic modality.
Clayburgh DR, Gross ND, Proby C, Koide J, Wong MH.
Head Neck · research support, non-u.s. gov't; research-article; journal article · DOI 10.1002/hed.22936The HDAC inhibitor LBH589 enhances the antimyeloma effects of the IGF-1RTK inhibitor picropodophyllin.
Lemaire M, Fristedt C, Agarwal P, Menu E, Van Valckenborgh E, De Bruyne E, Österborg A, Atadja P, Larsson O, Axelson M, Van Camp B, Jernberg-Wiklund H, Vanderkerken K.
Clin Cancer Res · research support, non-u.s. gov't; journal article · DOI 10.1158/1078-0432.ccr-11-1764The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology.
Pollak M.
Clin Cancer Res · journal article · DOI 10.1158/1078-0432.ccr-11-0998Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications.
Feng X, Aleem E, Lin Y, Axelson M, Larsson O, Strömberg T.
Int J Oncol · research support, non-u.s. gov't; research-article; journal article · DOI 10.3892/ijo.2011.1281Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP).
Hashemi J, Worrall C, Vasilcanu D, Fryknäs M, Sulaiman L, Karimi M, Weng WH, Lui WO, Rudduck C, Axelson M, Jernberg-Wiklund H, Girnita L, Larsson O, Larsson C.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0014757Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma.
Vishwamitra D, Shi P, Wilson D, Manshouri R, Vega F, Schlette EJ, Amin HM.
Haematologica · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.3324/haematol.2010.031567Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation.
Doghman M, Axelson M, Lalli E.
Am J Cancer Res · research-article; journal articleDetermination of picropodophyllin and its isomer podophyllotoxin in human serum samples with electrospray ionization of hexylamine adducts by liquid chromatography-tandem mass spectrometry.
Rönquist-Nii Y, Eksborg S, Axelson M, Harmenberg J, Ekman S, Bergqvist M, Beck O.
J Chromatogr B Analyt Technol Biomed Life Sci · journal article · DOI 10.1016/j.jchromb.2010.12.017Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma.
Yin S, Girnita A, Strömberg T, Khan Z, Andersson S, Zheng H, Ericsson C, Axelson M, Nistér M, Larsson O, Ekström TJ, Girnita L.
Neuro Oncol · research support, non-u.s. gov't; research-article; journal article · DOI 10.1093/neuonc/nop008Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066. Part I: process development.
Tang YJ, Li Y, Zhong JJ.
Bioprocess Biosyst Eng · research support, non-u.s. gov't; journal article · DOI 10.1007/s00449-008-0290-9Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066, part II: process optimization.
Li Y, Li YY, Mi ZY, Li DS, Tang YJ.
Bioresour Technol · research support, non-u.s. gov't; journal article · DOI 10.1016/j.biortech.2008.10.044