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Publications in the selection

50 hits

Bibliografisk träff 2010-05-07

Synthesis, structural elucidation and in vitro antiparasitic activity against Trypanosoma cruzi and Leishmania chagasi parasites of novel tetrahydro-1-benzazepine derivatives.

Gómez-Ayala S, Castrillón JA, Palma A, Leal SM, Escobar P, Bahsas A.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2010.05.018

Bibliografisk träff 2010-05-01

Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds.

Sanchez LM, Lopez D, Vesely BA, Della Togna G, Gerwick WH, Kyle DE, Linington RG.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm100265s

Bibliografisk träff 2010-03-01

Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.

Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J, Rosenthal PJ, Schmuck C, Schirmeister T.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm900946n

Bibliografisk träff 2009-12-01

Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.

Cavalli A, Bolognesi ML.

J Med Chem · research support, non-u.s. gov't; review; journal article · DOI 10.1021/jm9004835

Bibliografisk träff 2009-10-20

New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and mechanism of action studies.

Rodríguez J, Arán VJ, Boiani L, Olea-Azar C, Lavaggi ML, González M, Cerecetto H, Maya JD, Carrasco-Pozo C, Cosoy HS.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.10.030

Bibliografisk träff 2009-09-18

Anti-trypanosomatid benzofuroxans and deoxygenated analogues: synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies.

Castro D, Boiani L, Benitez D, Hernández P, Merlino A, Gil C, Olea-Azar C, González M, Cerecetto H, Porcal W.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.09.009

Bibliografisk träff 2009-09-15

5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene.

Gerpe A, Alvarez G, Benítez D, Boiani L, Quiroga M, Hernández P, Sortino M, Zacchino S, González M, Cerecetto H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.09.013

Bibliografisk träff 2009-09-01

On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.

Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J, Rosenthal PJ, Kisker C, Leyh M, Schmuck C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm900629w

Bibliografisk träff 2009-06-18

Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: synthesis, biological evaluation, and mode of action studies.

Boiani M, Boiani L, Merlino A, Hernández P, Chidichimo A, Cazzulo JJ, Cerecetto H, González M.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.06.014

Bibliografisk träff 2009-06-17

Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure-activity relationships.

Donnici CL, Araújo MH, Oliveira HS, Moreira DR, Pereira VR, de Assis Souza M, de Castro MC, Leite AC.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.05.071

Bibliografisk träff 2009-04-14

5-Nitro-2-furyl derivative actives against Trypanosoma cruzi: preliminary in vivo studies.

Cabrera E, Murguiondo MG, Arias MG, Arredondo C, Pintos C, Aguirre G, Fernández M, Basmadjián Y, Rosa R, Pacheco JP, Raymondo S, Di Maio R, González M, Cerecetto H.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.04.015

Bibliografisk träff 2009-01-15

New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships.

Bollini M, Casal JJ, Casal JJ, Alvarez DE, Boiani L, González M, Cerecetto H, Bruno AM.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2009.01.011

Bibliografisk träff 2009-01-01

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A.

Linington RG, Clark BR, Trimble EE, Almanza A, Ureña LD, Kyle DE, Gerwick WH.

J Nat Prod · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/np8003529

Bibliografisk träff 2008-12-03

Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates.

Romeiro NC, Aguirre G, Hernández P, González M, Cerecetto H, Aldana I, Pérez-Silanes S, Monge A, Barreiro EJ, Lima LM.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.11.065

Bibliografisk träff 2008-12-01

Antileishmanial constituents of the Panamanian endophytic fungus Edenia sp.

Martínez-Luis S, Della-Togna G, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L.

J Nat Prod · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/np800472q

Bibliografisk träff 2008-09-18

Synthesis, cytotoxicity, and anti-Trypanosoma cruzi activity of new chalcones.

Aponte JC, Verástegui M, Málaga E, Zimic M, Quiliano M, Vaisberg AJ, Gilman RH, Hammond GB.

J Med Chem · research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm800812k

Bibliografisk träff 2008-08-21

Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis.

Simmons TL, Engene N, Ureña LD, Romero LI, Ortega-Barría E, Gerwick L, Gerwick WH.

J Nat Prod · research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/np800110e

Bibliografisk träff 2008-07-29

Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: mechanism of action studies.

Boiani L, Aguirre G, González M, Cerecetto H, Chidichimo A, Cazzulo JJ, Bertinaria M, Guglielmo S.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.07.077

Bibliografisk träff 2008-07-23

Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: electrochemical behaviour and ESR spectroscopic studies.

Rodríguez J, Gerpe A, Aguirre G, Kemmerling U, Piro OE, Arán VJ, Maya JD, Olea-Azar C, González M, Cerecetto H.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2008.07.018

Bibliografisk träff 2008-05-20

New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle.

Porcal W, Hernández P, Boiani L, Boiani M, Ferreira A, Chidichimo A, Cazzulo JJ, Olea-Azar C, González M, Cerecetto H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2008.05.038

Bibliografisk träff 2008-05-06

Synthesis and in vitro activity of new tetrahydronaphtho[1,2-b]azepine derivatives against Trypanosoma cruzi and Leishmania chagasi parasites.

Palma A, Yépes AF, Leal SM, Coronado CA, Escobar P.

Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2008.05.013

Bibliografisk träff 2007-12-28

In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease.

Boiani L, Davies C, Arredondo C, Porcal W, Merlino A, Gerpe A, Boiani M, Pacheco JP, Basombrío MA, Cerecetto H, González M.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2007.12.016

Bibliografisk träff 2007-12-04

Imidazolidines as new anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships.

Caterina MC, Perillo IA, Boiani L, Pezaroglo H, Cerecetto H, González M, Salerno A.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.11.077

Bibliografisk träff 2007-11-04

Pyrimido[1,2-a]quinoxaline 6-oxide and phenazine 5,10-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi.

Lavaggi ML, Aguirre G, Boiani L, Orelli L, García B, Cerecetto H, González M.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2007.10.031

Bibliografisk träff 2007-10-26

In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.

Porcal W, Hernández P, Boiani M, Aguirre G, Boiani L, Chidichimo A, Cazzulo JJ, Campillo NE, Paez JA, Castro A, Krauth-Siegel RL, Davies C, Basombrío MA, González M, Cerecetto H.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm070604e

Bibliografisk träff 2007-10-18

Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.

Salas C, Tapia RA, Ciudad K, Armstrong V, Orellana M, Kemmerling U, Ferreira J, Maya JD, Morello A.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.10.038

Bibliografisk träff 2007-08-21

Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action.

Gerpe A, Odreman-Nuñez I, Draper P, Boiani L, Urbina JA, González M, Cerecetto H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.07.031

Bibliografisk träff 2007-07-13

Hydroxyalkenylresorcinols from Stylogyne turbacensis.

Jiménez-Romero C, Torres-Mendoza D, Ureña González LD, Ortega-Barría E, McPhail KL, Gerwick WH, Cubilla-Rios L.

J Nat Prod · research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/np070081d

Bibliografisk träff 2007-07-10

4-nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity.

Pérez-Rebolledo A, Teixeira LR, Batista AA, Mangrich AS, Aguirre G, Cerecetto H, González M, Hernández P, Ferreira AM, Speziali NL, Beraldo H.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2007.06.020

Bibliografisk träff 2007-01-12

Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships.

Porcal W, Hernández P, Aguirre G, Boiani L, Boiani M, Merlino A, Ferreira A, Maio RD, Castro A, González M, Cerecetto H.

Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.01.009