Therapies for pulmonary arterial hypertension: where are we today, where do we go tomorrow?
Seferian A, Simonneau G.
Eur Respir Rev · review-article; review; journal article · DOI 10.1183/09059180.00001713 PUBLICATION REGISTRY
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23 hitsChronic post-embolic pulmonary hypertension: a new target for medical therapies?
Delcroix M.
Eur Respir Rev · review-article; review; journal article · DOI 10.1183/09059180.00003513Effects of different pulmonary vasodilators on arterial saturation in a model of pulmonary hypertension.
Becker EM, Stasch JP, Bechem M, Keldenich J, Klipp A, Schaefer K, Ulbrich HF, Truebel H.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0073502The chemistry and biology of soluble guanylate cyclase stimulators and activators.
Follmann M, Griebenow N, Hahn MG, Hartung I, Mais FJ, Mittendorf J, Schäfer M, Schirok H, Stasch JP, Stoll F, Straub A.
Angew Chem Int Ed Engl · review; journal article · DOI 10.1002/anie.201302588Hypertension: Riociguat therapy for pulmonary hypertension.
Lim GB.
Nat Rev Cardiol · comment; journal article · DOI 10.1038/nrcardio.2013.122Riociguat for the treatment of chronic thromboembolic pulmonary hypertension.
Ghofrani HA, D'Armini AM, Grimminger F, Hoeper MM, Jansa P, Kim NH, Mayer E, Simonneau G, Wilkins MR, Fritsch A, Neuser D, Weimann G, Wang C, CHEST-1 Study Group.
N Engl J Med · clinical trial, phase iii; research support, non-u.s. gov't; multicenter study; randomized controlled trial; journal article · DOI 10.1056/nejmoa1209657Riociguat for the treatment of pulmonary arterial hypertension.
Ghofrani HA, Galiè N, Grimminger F, Grünig E, Humbert M, Jing ZC, Keogh AM, Langleben D, Kilama MO, Fritsch A, Neuser D, Rubin LJ, PATENT-1 Study Group.
N Engl J Med · clinical trial, phase iii; research support, non-u.s. gov't; multicenter study; randomized controlled trial; journal article · DOI 10.1056/nejmoa1209655Riociguat for pulmonary hypertension--a glass half full.
Archer SL.
N Engl J Med · comment; editorial · DOI 10.1056/nejme1306684Riociguat for patients with pulmonary hypertension caused by systolic left ventricular dysfunction: a phase IIb double-blind, randomized, placebo-controlled, dose-ranging hemodynamic study.
Bonderman D, Ghio S, Felix SB, Ghofrani HA, Michelakis E, Mitrovic V, Oudiz RJ, Boateng F, Scalise AV, Roessig L, Semigran MJ, Left Ventricular Systolic Dysfunction Associated With Pulmonary Hypertension Riociguat Trial (LEPHT) Study Group.
Circulation · clinical trial, phase ii; research support, non-u.s. gov't; randomized controlled trial; journal article · DOI 10.1161/circulationaha.113.001458Recent progress in the diagnosis and management of chronic thromboembolic pulmonary hypertension.
Tanabe N, Sugiura T, Tatsumi K.
Respir Investig · research support, non-u.s. gov't; review; journal article · DOI 10.1016/j.resinv.2013.02.005Chronic thromboembolic pulmonary hypertension: role of medical therapy.
Pepke-Zaba J, Jansa P, Kim NH, Naeije R, Simonneau G.
Eur Respir J · review; journal article · DOI 10.1183/09031936.00201612Soluble guanylate cyclase stimulators in pulmonary hypertension.
Stasch JP, Evgenov OV.
Handb Exp Pharmacol · review; journal article · DOI 10.1007/978-3-642-38664-0_12Pathways in pulmonary arterial hypertension: the future is here.
Sitbon O, Morrell N.
Eur Respir Rev · review-article; review; journal article · DOI 10.1183/09059180.00004812Riociguat for interstitial lung disease and pulmonary hypertension: a pilot trial.
Hoeper MM, Halank M, Wilkens H, Günther A, Weimann G, Gebert I, Leuchte HH, Behr J.
Eur Respir J · clinical trial, phase ii; research support, non-u.s. gov't; multicenter study; journal article · DOI 10.1183/09031936.00213911The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.
Lang M, Kojonazarov B, Tian X, Kalymbetov A, Weissmann N, Grimminger F, Kretschmer A, Stasch JP, Seeger W, Ghofrani HA, Schermuly RT.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0043433Effects of stimulation of soluble guanylate cyclase on diabetic nephropathy in diabetic eNOS knockout mice on top of angiotensin II receptor blockade.
Ott IM, Alter ML, von Websky K, Kretschmer A, Tsuprykov O, Sharkovska Y, Krause-Relle K, Raila J, Henze A, Stasch JP, Hocher B.
PLoS One · research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.pone.0042623Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): rationale and design.
Ghio S, Bonderman D, Felix SB, Ghofrani HA, Michelakis ED, Mitrovic V, Oudiz RJ, Frey R, Roessig L, Semigran MJ.
Eur J Heart Fail · clinical trial, phase ii; research support, non-u.s. gov't; randomized controlled trial; journal article · DOI 10.1093/eurjhf/hfs071Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats.
Geschka S, Kretschmer A, Sharkovska Y, Evgenov OV, Lawrenz B, Hucke A, Hocher B, Stasch JP.
PLoS One · research-article; journal article · DOI 10.1371/journal.pone.0021853Riociguat for the treatment of pulmonary hypertension.
Schermuly RT, Janssen W, Weissmann N, Stasch JP, Grimminger F, Ghofrani HA.
Expert Opin Investig Drugs · research support, non-u.s. gov't; review; journal article · DOI 10.1517/13543784.2011.565048Riociguat (BAY 63-2521) and warfarin: a pharmacodynamic and pharmacokinetic interaction study.
Frey R, Mück W, Kirschbaum N, Krätzschmar J, Weimann G, Wensing G.
J Clin Pharmacol · research support, non-u.s. gov't; randomized controlled trial; journal article · DOI 10.1177/0091270010378119Animal models related to congenital heart disease and clinical research in pulmonary hypertension.
Loukanov T, Geiger R, Agrawal R.
Cardiology · consensus statement; journal article · DOI 10.1159/000313865Riociguat: an upcoming therapy in chronic thromboembolic pulmonary hypertension?
Kim NH.
Eur Respir Rev · review-article; review; journal article · DOI 10.1183/09059180.00007909First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension.
Grimminger F, Weimann G, Frey R, Voswinckel R, Thamm M, Bölkow D, Weissmann N, Mück W, Unger S, Wensing G, Schermuly RT, Ghofrani HA.
Eur Respir J · research support, non-u.s. gov't; journal article · DOI 10.1183/09031936.00039808