Early events in vascular injury in the rat induced by the phosphodiesterase IV inhibitor SCH 351591.
Weaver JL, Zhang J, Knapton A, Miller T, Espandiari P, Smith R, Gu YZ, Snyder RD.
Toxicol Pathol · journal article · DOI 10.1177/0192623310374331 PUBLICATION REGISTRY
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8 hitsMyocardial and reproductive system toxicity of SCH 351591, a selective phosphodiesterase-4 inhibitor, in CD-1 mice.
Losco PE, Poulet FM, Kaminska-McNamara GZ, Klein MF.
Toxicol Pathol · journal article · DOI 10.1177/0192623310370463Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385.
Zhang J, Snyder RD, Herman EH, Knapton A, Honchel R, Miller T, Espandiari P, Goodsaid FM, Rosenblum IY, Hanig JP, Sistare FD, Weaver JL.
Toxicol Pathol · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1177/0192623308322308Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385.
Weaver JL, Snyder R, Knapton A, Herman EH, Honchel R, Miller T, Espandiari P, Smith R, Gu YZ, Goodsaid FM, Rosenblum IY, Sistare FD, Zhang J, Hanig J.
Toxicol Pathol · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1177/0192623308322310Differential type 4 cAMP-specific phosphodiesterase (PDE4) expression and functional sensitivity to PDE4 inhibitors among rats, monkeys and humans.
Bian H, Zhang J, Wu P, Varty LA, Jia Y, Mayhood T, Hey JA, Wang P.
Biochem Pharmacol · journal article · DOI 10.1016/j.bcp.2004.08.014The toxicity of SCH 351591, a novel phosphodiesterase-4 inhibitor, in Cynomolgus monkeys.
Losco PE, Evans EW, Barat SA, Blackshear PE, Reyderman L, Fine JS, Bober LA, Anthes JC, Mirro EJ, Cuss FM.
Toxicol Pathol · comparative study; journal article · DOI 10.1080/01926230490431493Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor.
Billah MM, Cooper N, Minnicozzi M, Warneck J, Wang P, Hey JA, Kreutner W, Rizzo CA, Smith SR, Young S, Chapman RW, Dyke H, Shih NY, Piwinski JJ, Cuss FM, Montana J, Ganguly AK, Egan RW.
J Pharmacol Exp Ther · clinical trial; journal article · DOI 10.1124/jpet.302.1.127Synthesis and profile of SCH351591, a novel PDE4 inhibitor.
Billah M, Cooper N, Cuss F, Davenport RJ, Dyke HJ, Egan R, Ganguly A, Gowers L, Hannah DR, Haughan AF, Kendall HJ, Lowe C, Minnicozzi M, Montana JG, Naylor R, Oxford J, Peake JC, Piwinski JJ, Runcie KA, Sabin V, Sharpe A, Shih NY, Warneck JB.
Bioorg Med Chem Lett · journal article · DOI 10.1016/s0960-894x(02)00225-1