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Publications in the selection

21 hits

Bibliografisk träff 2023-07-07

Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain.

Szczepańska K, Karcz T, Dichiara M, Mogilski S, Kalinowska-Tłuścik J, Pilarski B, Leniak A, Pietruś W, Podlewska S, Popiołek-Barczyk K, Humphrys LJ, Ruiz-Cantero MC, Reiner-Link D, Leitzbach L, Łażewska D, Pockes S, Górka M, Zmysłowski A, Calmels T, Cobos EJ, Marrazzo A, Stark H, Bojarski AJ, Amata E, Kieć-Kononowicz K.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.3c00430

Bibliografisk träff 2023-03-15

Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4'-piperidin]-1'-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques.

Abatematteo FS, Majellaro M, Montsch B, Prieto-Díaz R, Niso M, Contino M, Stefanachi A, Riganti C, Mangiatordi GF, Delre P, Heffeter P, Sotelo E, Abate C.

J Med Chem · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jmedchem.2c01227

Bibliografisk träff 2022-09-22

A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse.

Khan MIH, Sawyer BJ, Akins NS, Le HV.

Eur J Med Chem · systematic review; journal article · DOI 10.1016/j.ejmech.2022.114785

Bibliografisk träff 2022-06-17

Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands.

Zampieri D, Fortuna S, Romano M, Amata E, Dichiara M, Marrazzo A, Pasquinucci L, Turnaturi R, Mamolo MG.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2022.128860

Bibliografisk träff 2022-04-14

Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.

Bechthold E, Schreiber JA, Ritter N, Schepmann D, Daniliuc C, Seebohm G, Wünsch B.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114359

Bibliografisk träff 2022-01-13

Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity.

Bechthold E, Schreiber JA, Ritter N, Grey L, Schepmann D, Daniliuc C, González-Cano R, Nieto FR, Seebohm G, Wünsch B.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2022.114113

Bibliografisk träff 2022-01-05

Synthesis of 8-aminomorphans with high KOR affinity.

Jonas H, Aiello D, Schepmann D, Diana P, Wünsch B.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.114079

Bibliografisk träff 2022-01-01

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.

Dichiara M, Artacho-Cordón A, Turnaturi R, Santos-Caballero M, González-Cano R, Pasquinucci L, Barbaraci C, Rodríguez-Gómez I, Gómez-Guzmán M, Marrazzo A, Cobos EJ, Amata E.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.114091

Bibliografisk träff 2021-12-03

Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect.

Abatematteo FS, Mosier PD, Niso M, Brunetti L, Berardi F, Loiodice F, Contino M, Delprat B, Maurice T, Laghezza A, Abate C.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.114038

Bibliografisk träff 2021-04-20

Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ1 receptor affinity, antitumor and analgesic activity.

Kopp N, Civenni G, Marson D, Laurini E, Pricl S, Catapano CV, Humpf HU, Almansa C, Nieto FR, Schepmann D, Wünsch B.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2021.113443

Bibliografisk träff 2020-12-29

Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.

Peng Y, Zhang Q, Welsh WJ.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.0c01964

Bibliografisk träff 2020-12-09

Synthesis and σ receptor affinity of spiro[[2]benzopyran-1,1'-cyclohexanes] with an exocyclic amino moiety in the 3'-position.

Kronenberg E, Weber F, Schepmann D, Wünsch B.

RSC Med Chem · research-article; journal article · DOI 10.1039/d0md00307g

Bibliografisk träff 2020-10-28

Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.

Ye N, Qin W, Tian S, Xu Q, Wold EA, Zhou J, Zhen XC.

J Med Chem · research support, non-u.s. gov't; review; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jmedchem.0c01192

Bibliografisk träff 2020-10-22

Novel σ1 antagonists designed for tumor therapy: Structure - activity relationships of aminoethyl substituted cyclohexanes.

Kopp N, Holtschulte C, Börgel F, Lehmkuhl K, Friedland K, Civenni G, Laurini E, Catapano CV, Pricl S, Humpf HU, Schepmann D, Wünsch B.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2020.112950

Bibliografisk träff 2020-04-09

Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation.

Amata E, Dichiara M, Gentile D, Marrazzo A, Turnaturi R, Arena E, La Mantia A, Tomasello BR, Acquaviva R, Di Giacomo C, Rescifina A, Prezzavento O.

ACS Med Chem Lett · rapid-communication; journal article · DOI 10.1021/acsmedchemlett.9b00661

Bibliografisk träff 2019-05-16

Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity.

Thum S, Schepmann D, Ayet E, Pujol M, Nieto FR, Ametamey SM, Wünsch B.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.05.034

Bibliografisk träff 2019-01-09

Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.

Tangherlini G, Kalinin DV, Schepmann D, Che T, Mykicki N, Ständer S, Loser K, Wünsch B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b01609

Bibliografisk träff 2018-10-24

Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety.

Bergkemper M, Kronenberg E, Thum S, Börgel F, Daniliuc C, Schepmann D, Nieto FR, Brust P, Reinoso RF, Alvarez I, Wünsch B.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/acs.jmedchem.8b01183

Bibliografisk träff 2018-08-15

New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation.

Zampieri D, Romano M, Menegazzi R, Mamolo MG.

Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2018.08.016

Bibliografisk träff 2018-07-11

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.

Estrada Valencia M, Herrera-Arozamena C, de Andrés L, Pérez C, Morales-García JA, Pérez-Castillo A, Ramos E, Romero A, Viña D, Yáñez M, Laurini E, Pricl S, Rodríguez-Franco MI.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2018.07.026

Bibliografisk träff 2017-03-13

In silico design of novel probes for the atypical opioid receptor MRGPRX2.

Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL.

Nat Chem Biol · research-article; journal article · DOI 10.1038/nchembio.2334

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Publications in the selection

Dual Piperidine-Based Histamine H<sub>3</sub> and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain.

Development of Fluorescent 4-[4-(3<i>H</i>-Spiro[isobenzofuran-1,4'-piperidin]-1'-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques.

A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse.

Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands.

Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.

Synthesis of tropane-based σ<sub>1</sub> receptor antagonists with antiallodynic activity.

Synthesis of 8-aminomorphans with high KOR affinity.

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.

Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ<sub>1</sub>) receptor ligands with potent anti-amnesic effect.

Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ<sub>1</sub> receptor affinity, antitumor and analgesic activity.

Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.

Synthesis and <i>σ</i> receptor affinity of spiro[[2]benzopyran-1,1'-cyclohexanes] with an exocyclic amino moiety in the 3'-position.

Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.

Novel σ<sub>1</sub> antagonists designed for tumor therapy: Structure - activity relationships of aminoethyl substituted cyclohexanes.

Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation.

Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ<sub>1</sub> receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity.

Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.

Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety.

New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation.

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.

In silico design of novel probes for the atypical opioid receptor MRGPRX2.