Hologram QSAR model for the prediction of human oral bioavailability.
Moda TL, Montanari CA, Andricopulo AD.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.08.060 PUBLICATION REGISTRY
Go to research.
Publikationsdata från Europe PMC och PubMed. Följ källhänvisningar från ämnesregistret till originalpublikationerna.
Publikationer som ChEBI hänvisar till för phenobarbital. Visa hela publikationsregistret
A publication hit is not a conclusion. Publikationslistan visar bibliografiska uppgifter. Eventuella forskningsutdrag visas separat med originalunderlag. En källhänvisning visar inte i sig effekt, dosering eller säkerhet.
Publications in the selection
52 hitsTransdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Baert B, Deconinck E, Van Gele M, Slodicka M, Stoppie P, Bodé S, Slegers G, Vander Heyden Y, Lambert J, Beetens J, De Spiegeleer B.
Bioorg Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmc.2007.07.050Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach.
Yogeeswari P, Sriram D, Sahitya P, Ragavendran JV, Ranganadh V.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2007.04.032In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
Ottaviani G, Martel S, Carrupt PA.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0611105Synthesis and anticonvulsant activity of new N-1',N-3'-disubstituted-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-triones.
Patel HJ, Sarra J, Caruso F, Rossi M, Doshi U, Stephani RA.
Bioorg Med Chem Lett · journal article · DOI 10.1016/j.bmcl.2006.05.102Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
Ottaviani G, Martel S, Carrupt PA.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm060230+Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Xie ZF, Chai KY, Piao HR, Kwak KC, Quan ZS.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2005.07.051Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
Yogeeswari P, Sriram D, Thirumurugan R, Raghavendran JV, Sudhan K, Pavana RK, Stables J.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm050283bCalculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Caron G, Ermondi G.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm048980bThe pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Du LP, Tsai KC, Li MY, You QD, Xia L.
Bioorg Med Chem Lett · comparative study; research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2004.06.070Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Bruno-Blanch L, Gálvez J, García-Domenech R.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00535-3Design and evaluation of affinity labels of functionalized amino acid anticonvulsants.
LeTiran A, Stables JP, Kohn H.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm020225fSynthesis and structural studies of aza analogues of functionalized amino acids: new anticonvulsant agents.
Andurkar SV, Béguin C, Stables JP, Kohn H.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm000517lPrediction of drug solubility from Monte Carlo simulations.
Jorgensen WL, Duffy EM.
Bioorg Med Chem Lett · research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1016/s0960-894x(00)00172-4QSAR model for drug human oral bioavailability.
Yoshida F, Topliss JG.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm0000564Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives.
Ucar H, Van derpoorten K, Cacciaguerra S, Spampinato S, Stables JP, Depovere P, Isa M, Masereel B, Delarge J, Poupaert JH.
J Med Chem · journal article · DOI 10.1021/jm970682+Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams).
Reddy PA, Woodward KE, McIlheran SM, Hsiang BC, Latifi TN, Hill MW, Rothman SM, Ferrendelli JA, Covey DF.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm960561u3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents.
Reddy PA, Hsiang BC, Latifi TN, Hill MW, Woodward KE, Rothman SM, Ferrendelli JA, Covey DF.
J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm9600196Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.
Flaherty PT, Greenwood TD, Manheim AL, Wolfe JF.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm950761qSynthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations.
Scott KR, Rankin GO, Stables JP, Alexander MS, Edafiogho IO, Farrar VA, Kolen KR, Moore JA, Sims LD, Tonnu AD.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1021/jm00020a019Synthesis and anticonvulsant activities of alpha-acetamido-N-benzylacetamide derivatives containing an electron-deficient alpha-heteroaromatic substituent.
Bardel P, Bolanos A, Kohn H.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00052a017Synthesis and anticonvulsant properties of new benzylpyridazine derivatives.
Moreau S, Coudert P, Rubat C, Gardette D, Vallee-Goyet D, Couquelet J, Bastide P, Tronche P.
J Med Chem · journal article · DOI 10.1021/jm00040a006Synthesis and CLOGP correlation of imidooxy anticonvulsants.
Farrar VA, Ciechanowicz-Rutkowska M, Grochowski J, Serda P, Pilati T, Filippini G, Hinko CN, el-Assadi A, Moore JA, Edafiogho IO.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00075a005Synthesis and anticonvulsant activities of alpha-heterocyclic alpha-acetamido-N-benzylacetamide derivatives.
Kohn H, Sawhney KN, Bardel P, Robertson DW, Leander JD.
J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm00074a016Synthesis and anticonvulsant activity of enaminones.
Edafiogho IO, Hinko CN, Chang H, Moore JA, Mulzac D, Nicholson JM, Scott KR.
J Med Chem · research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00093a0122-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Tomczuk BE, Taylor CR, Moses LM, Sutherland DB, Lo YS, Johnson DN, Kinnier WB, Kilpatrick BF.
J Med Chem · journal article · DOI 10.1021/jm00114a007Preparation and anticonvulsant activity of a series of functionalized alpha-heteroatom-substituted amino acids.
Kohn H, Sawhney KN, LeGall P, Robertson DW, Leander JD.
J Med Chem · comparative study; journal article · DOI 10.1021/jm00112a020Synthesis and anticonvulsant activity of 2-iminohydantoins.
Kwon CH, Iqbal MT, Wurpel JN.
J Med Chem · journal article · DOI 10.1021/jm00110a013Synthesis and anticonvulsant activity of imidooxy derivatives.
Edafiogho IO, Scott KR, Moore JA, Farrar VA, Nicholson JM.
J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; research support, non-u.s. gov't; journal article · DOI 10.1021/jm00105a0592,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents.
Kane JM, Baron BM, Dudley MW, Sorensen SM, Staeger MA, Miller FP.
J Med Chem · journal article · DOI 10.1021/jm00172a015