Bryostatin 1 causes attenuation of TPA‑mediated tumor promotion in mouse skin.
Zeng N, Xu Y, Wu Y, Hongbo T, Wu M.
Mol Med Rep · journal article · DOI 10.3892/mmr.2017.7993 PUBLICATION REGISTRY
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39 hitsMaking Bryostatin 1 through Smart Chemistry.
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Cancer Discov · journal article · DOI 10.1158/2159-8290.cd-nb2017-148Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV.
Wender PA, Hardman CT, Ho S, Jeffreys MS, Maclaren JK, Quiroz RV, Ryckbosch SM, Shimizu AJ, Sloane JL, Stevens MC.
Science · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1126/science.aan7969In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.
Marsden MD, Loy BA, Wu X, Ramirez CM, Schrier AJ, Murray D, Shimizu A, Ryckbosch SM, Near KE, Chun TW, Wender PA, Zack JA.
PLoS Pathog · research-article; journal article · DOI 10.1371/journal.ppat.1006575Bryostatin and its synthetic analog, picolog rescue dermal fibroblasts from prolonged stress and contribute to survival and rejuvenation of human skin equivalents.
Khan TK, Wender PA, Alkon DL.
J Cell Physiol · research-article; journal article · DOI 10.1002/jcp.26043The CCR5-antagonist Maraviroc reverses HIV-1 latency in vitro alone or in combination with the PKC-agonist Bryostatin-1.
López-Huertas MR, Jiménez-Tormo L, Madrid-Elena N, Gutiérrez C, Rodríguez-Mora S, Coiras M, Alcamí J, Moreno S.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41598-017-02634-yThe effect of Ingenol-B on the suppressive capacity of elite suppressor HIV-specific CD8+ T cells.
Kwaa AK, Goldsborough K, Walker-Sperling VE, Pianowski LF, Gama L, Blankson JN.
PLoS One · research-article; journal article · DOI 10.1371/journal.pone.0174516Effects of chronic bryostatin-1 on treatment-resistant depression in rats.
Alkon DL, Hongpaisan J, Sun MK.
Eur J Pharmacol · journal article · DOI 10.1016/j.ejphar.2017.05.001Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer's Disease Phase IIa and Expanded Access Trials.
Nelson TJ, Sun MK, Lim C, Sen A, Khan T, Chirila FV, Alkon DL.
J Alzheimers Dis · clinical trial, phase ii; research-article; randomized controlled trial; journal article; research support, n.i.h., extramural · DOI 10.3233/jad-170161HIV-1 Latency-Reversing Agents Prostratin and Bryostatin-1 Induce Blood-Brain Barrier Disruption/Inflammation and Modulate Leukocyte Adhesion/Transmigration.
Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ.
J Immunol · journal article · DOI 10.4049/jimmunol.1600742In vitro effects of the small-molecule protein kinase C agonists on HIV latency reactivation.
Brogdon J, Ziani W, Wang X, Veazey RS, Xu H.
Sci Rep · research-article; journal article; research support, n.i.h., extramural · DOI 10.1038/srep39032PKC Activation Counteracts ADAM10 Deficit in HuD-Silenced Neuroblastoma Cells.
Marchesi N, Amadio M, Colombrita C, Govoni S, Ratti A, Pascale A.
J Alzheimers Dis · journal article · DOI 10.3233/jad-160299Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy.
Gutiérrez C, Serrano-Villar S, Madrid-Elena N, Pérez-Elías MJ, Martín ME, Barbas C, Ruipérez J, Muñoz E, Muñoz-Fernández MA, Castor T, Moreno S.
AIDS · research support, non-u.s. gov't; clinical trial, phase i; journal article · DOI 10.1097/qad.0000000000001064Effects of exercise and bryostatin-1 on serotonin dynamics after cerebral infarction.
Mizutani K, Sonoda S, Wakita H, Okazaki H, Katoh Y, Chihara T, Shimpo K.
Neuroreport · research support, non-u.s. gov't; journal article · DOI 10.1097/wnr.0000000000000592Isolation, analytical measurements, and cell line studies of the iron-bryostatin-1 complex.
Plummer S, Manning T, Baker T, McGreggor T, Patel M, Wylie G, Phillips D.
Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2016.03.099Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1.
Martínez-Bonet M, Clemente MI, Serramía MJ, Muñoz E, Moreno S, Muñoz-Fernández MÁ.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/srep16445An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression.
Darcis G, Kula A, Bouchat S, Fujinaga K, Corazza F, Ait-Ammar A, Delacourt N, Melard A, Kabeya K, Vanhulle C, Van Driessche B, Gatot JS, Cherrier T, Pianowski LF, Gama L, Schwartz C, Vila J, Burny A, Clumeck N, Moutschen M, De Wit S, Peterlin BM, Rouzioux C, Rohr O, Van Lint C.
PLoS Pathog · comparative study; research support, non-u.s. gov't; research-article; journal article · DOI 10.1371/journal.ppat.1005063Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships.
Kedei N, Kraft MB, Keck GE, Herald CL, Melody N, Pettit GR, Blumberg PM.
J Nat Prod · research support, n.i.h., intramural; research support, non-u.s. gov't; review-article; journal article; research support, n.i.h., extramural · DOI 10.1021/acs.jnatprod.5b00094Protein kinase C activator, bryostatin-1, promotes exercise-dependent functional recovery in rats with cerebral infarction.
Mizutani K, Sonoda S, Wakita H, Shimpo K.
Am J Phys Med Rehabil · research support, non-u.s. gov't; journal article · DOI 10.1097/phm.0000000000000227Acute oral Bryostatin-1 administration improves learning deficits in the APP/PS1 transgenic mouse model of Alzheimer's disease.
Schrott LM, Jackson K, Yi P, Dietz F, Johnson GS, Basting TF, Purdum G, Tyler T, Rios JD, Castor TP, Alexander JS.
Curr Alzheimer Res · journal article; research support, n.i.h., extramural · DOI 10.2174/1567205012666141218141904Bryostatin-1 causes radiosensitization of BMG-1 malignant glioma cells through differential activation of protein kinase-Cδ not evident in the non-malignant AA8 fibroblasts.
Dagur RS, Hambarde S, Chandna S.
Mol Cell Biochem · research support, non-u.s. gov't; journal article · DOI 10.1007/s11010-014-2291-0Bryostatin-1 Restores Blood Brain Barrier Integrity following Blast-Induced Traumatic Brain Injury.
Lucke-Wold BP, Logsdon AF, Smith KE, Turner RC, Alkon DL, Tan Z, Naser ZJ, Knotts CM, Huber JD, Rosen CL.
Mol Neurobiol · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1007/s12035-014-8902-7A phase I study of temsirolimus and bryostatin-1 in patients with metastatic renal cell carcinoma and soft tissue sarcoma.
Plimack ER, Tan T, Wong YN, von Mehren MM, Malizzia L, Roethke SK, Litwin S, Li T, Hudes GR, Haas NB.
Oncologist · brief-report; clinical trial, phase i; journal article · DOI 10.1634/theoncologist.2014-0020Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile x mice.
Sun MK, Hongpaisan J, Lim CS, Alkon DL.
J Pharmacol Exp Ther · journal article · DOI 10.1124/jpet.114.214098Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.
Irie K, Yanagita RC.
Chem Rec · research support, non-u.s. gov't; review; journal article · DOI 10.1002/tcr.201300036Adduct formation in liquid chromatography-triple quadrupole mass spectrometric measurement of bryostatin 1.
Nelson TJ, Sen A, Alkon DL, Sun MK.
J Chromatogr B Analyt Technol Biomed Life Sci · journal article · DOI 10.1016/j.jchromb.2013.11.020Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, Keck GE.
ACS Chem Biol · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/cb300671sComparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.
Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM.
Biochem Pharmacol · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bcp.2012.10.028Bryostatin-1 promotes long-term potentiation via activation of PKCα and PKCε in the hippocampus.
Kim H, Han SH, Quan HY, Jung YJ, An J, Kang P, Park JB, Yoon BJ, Seol GH, Min SS.
Neuroscience · research support, non-u.s. gov't; journal article · DOI 10.1016/j.neuroscience.2012.08.055Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.
Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Blumberg PM.
Bioorg Med Chem Lett · research support, n.i.h., intramural; research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.bmcl.2012.04.073