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Publikationer som ChEBI hänvisar till för cobimetinib. Visa hela publikationsregistret

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Publications in the selection

11 hits

Bibliografisk träff 2015-10-08

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.

Takahashi RH, Choo EF, Ma S, Wong S, Halladay J, Deng Y, Rooney I, Gates M, Hop CE, Khojasteh SC, Dresser MJ, Musib L.

Drug Metab Dispos · clinical trial; journal article · DOI 10.1124/dmd.115.066282

Bibliografisk träff 2015-10-01

Cobimetinib: First Global Approval.

Garnock-Jones KP.

Drugs · review; journal article · DOI 10.1007/s40265-015-0477-8

Bibliografisk träff 2015-09-18

Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells.

Singh A, Ruan Y, Tippett T, Narendran A.

J Exp Clin Cancer Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1186/s13046-015-0222-x

Bibliografisk träff 2015-09-13

Population pharmacokinetics and dosing implications for cobimetinib in patients with solid tumors.

Han K, Jin JY, Marchand M, Eppler S, Choong N, Hack SP, Tikoo N, Bruno R, Dresser M, Musib L, Budha NR.

Cancer Chemother Pharmacol · comparative study; journal article · DOI 10.1007/s00280-015-2862-0

Bibliografisk träff 2015-03-26

Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor.

Choo EF, Woolsey S, DeMent K, Ly J, Messick K, Qin A, Takahashi R.

Drug Metab Dispos · comparative study; journal article · DOI 10.1124/dmd.115.063743

Bibliografisk träff 2014-11-01

Involution of eruptive melanocytic nevi on combination BRAF and MEK inhibitor therapy.

Chen FW, Tseng D, Reddy S, Daud AI, Swetter SM.

JAMA Dermatol · journal article; case reports · DOI 10.1001/jamadermatol.2014.838

Bibliografisk träff 2014-10-07

Determination of cobimetinib in human plasma using protein precipitation extraction and high-performance liquid chromatography coupled to mass spectrometry.

Deng Y, Musib L, Choo E, Chapple M, Burke S, Johnson J, Eppler S, Dean B.

J Chromatogr B Analyt Technol Biomed Life Sci · randomized controlled trial; journal article · DOI 10.1016/j.jchromb.2014.09.034

Bibliografisk träff 2014-10-03

Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib.

Choo EF, Ly J, Chan J, Shahidi-Latham SK, Messick K, Plise E, Quiason CM, Yang L.

Mol Pharm · journal article · DOI 10.1021/mp500435s

Bibliografisk träff 2014-09-29

Combined vemurafenib and cobimetinib in BRAF-mutated melanoma.

Larkin J, Ascierto PA, Dréno B, Atkinson V, Liszkay G, Maio M, Mandalà M, Demidov L, Stroyakovskiy D, Thomas L, de la Cruz-Merino L, Dutriaux C, Garbe C, Sovak MA, Chang I, Choong N, Hack SP, McArthur GA, Ribas A.

N Engl J Med · clinical trial, phase iii; research support, non-u.s. gov't; multicenter study; randomized controlled trial; journal article · DOI 10.1056/nejmoa1408868

Bibliografisk träff 2014-07-15

Combination of vemurafenib and cobimetinib in patients with advanced BRAF(V600)-mutated melanoma: a phase 1b study.

Ribas A, Gonzalez R, Pavlick A, Hamid O, Gajewski TF, Daud A, Flaherty L, Logan T, Chmielowski B, Lewis K, Kee D, Boasberg P, Yin M, Chan I, Musib L, Choong N, Puzanov I, McArthur GA.

Lancet Oncol · comparative study; research support, non-u.s. gov't; multicenter study; clinical trial, phase i; randomized controlled trial; journal article · DOI 10.1016/s1470-2045(14)70301-8

Bibliografisk träff 2014-03-03

Efficacy of intermittent combined RAF and MEK inhibition in a patient with concurrent BRAF- and NRAS-mutant malignancies.

Abdel-Wahab O, Klimek VM, Gaskell AA, Viale A, Cheng D, Kim E, Rampal R, Bluth M, Harding JJ, Callahan MK, Merghoub T, Berger MF, Solit DB, Rosen N, Levine RL, Chapman PB.

Cancer Discov · research support, non-u.s. gov't; research-article; journal article; case reports; research support, n.i.h., extramural · DOI 10.1158/2159-8290.cd-13-1038