A novel antimetabolite: TAS-102 for metastatic colorectal cancer.
Miyamoto Y, Lenz HJ, Baba H.
Expert Rev Clin Pharmacol · research support, non-u.s. gov't; research-article; review; journal article · DOI 10.1586/17512433.2016.1133285 PUBLICATION REGISTRY
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21 hitsTAS-102 an Emerging Oral Fluoropyrimidine.
Chen J, Han M, Saif MW.
Anticancer Res · review; journal articleNew active drugs for the treatment of advanced colorectal cancer.
Zaniboni A.
World J Gastrointest Surg · editorial; journal article · DOI 10.4240/wjgs.v7.i12.356TAS-102: a novel antimetabolite for the 21st century.
Uboha N, Hochster HS.
Future Oncol · review-article; review; journal article · DOI 10.2217/fon.15.276Safety and Efficacy of Trifluridine/Tipiracil Monotherapy in Clinical Practice for Patients With Metastatic Colorectal Cancer: Experience at a Single Institution.
Kotani D, Shitara K, Kawazoe A, Fukuoka S, Kuboki Y, Bando H, Okamoto W, Kojima T, Doi T, Ohtsu A, Yoshino T.
Clin Colorectal Cancer · journal article · DOI 10.1016/j.clcc.2015.11.005Pharmaceutical Approval Update.
Gohil K.
P T · other; journal articleTAS-102 for the treatment of metastatic colorectal cancer.
Salvatore L, Rossini D, Moretto R, Cremolini C, Schirripa M, Antoniotti C, Marmorino F, Loupakis F, Falcone A, Masi G.
Expert Rev Anticancer Ther · review; journal article · DOI 10.1586/14737140.2015.1105746New Medical Devices.
Författaruppgift saknas
P T · news; journal articlePhase 1 study of oral TAS-102 in patients with refractory metastatic colorectal cancer.
Bendell JC, Rosen LS, Mayer RJ, Goldman JW, Infante JR, Benedetti F, Lin D, Mizuguchi H, Zergebel C, Patel MR.
Cancer Chemother Pharmacol · research support, non-u.s. gov't; research-article; multicenter study; clinical trial, phase i; journal article · DOI 10.1007/s00280-015-2850-4Efficacy of Combination Chemotherapy Using a Novel Oral Chemotherapeutic Agent, TAS-102, with Oxaliplatin on Human Colorectal and Gastric Cancer Xenografts.
Nukatsuka M, Nakagawa F, Takechi T.
Anticancer Res · journal articlePhase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer.
Doi T, Yoshino T, Fuse N, Boku N, Yamazaki K, Koizumi W, Shimada K, Takinishi Y, Ohtsu A.
Invest New Drugs · research support, non-u.s. gov't; research-article; clinical trial, phase i; journal article · DOI 10.1007/s10637-015-0271-1[Initial Evaluation of the Efficacy and Safety of Tablets Containing Trifluridine and Tipiracil Hydrochloride--Safety Measures Devised by a Multidisciplinary Team Including a Pharmaceutical Outpatient Clinic].
Aimono Y, Kamoshida T, Sakamoto R, Nemoto M, Saito Y, Aoyama Y, Maruyama T.
Gan To Kagaku Ryoho · journal article; english abstractExposure-dependent incorporation of trifluridine into DNA of tumors and white blood cells in tumor-bearing mouse.
Yamashita F, Komoto I, Oka H, Kuwata K, Takeuchi M, Nakagawa F, Yoshisue K, Chiba M.
Cancer Chemother Pharmacol · journal article · DOI 10.1007/s00280-015-2805-9TAS-102, a novel antitumor agent: a review of the mechanism of action.
Lenz HJ, Stintzing S, Loupakis F.
Cancer Treat Rev · research support, non-u.s. gov't; research-article; review; journal article · DOI 10.1016/j.ctrv.2015.06.001Randomized trial of TAS-102 for refractory metastatic colorectal cancer.
Mayer RJ, Van Cutsem E, Falcone A, Yoshino T, Garcia-Carbonero R, Mizunuma N, Yamazaki K, Shimada Y, Tabernero J, Komatsu Y, Sobrero A, Boucher E, Peeters M, Tran B, Lenz HJ, Zaniboni A, Hochster H, Cleary JM, Prenen H, Benedetti F, Mizuguchi H, Makris L, Ito M, Ohtsu A, RECOURSE Study Group.
N Engl J Med · clinical trial, phase iii; research support, non-u.s. gov't; multicenter study; randomized controlled trial; journal article · DOI 10.1056/nejmoa1414325Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluridine Using Human Small Intestinal Epithelial Cells.
Takahashi K, Yoshisue K, Chiba M, Nakanishi T, Tamai I.
J Pharm Sci · journal article · DOI 10.1002/jps.24455Crucial roles of thymidine kinase 1 and deoxyUTPase in incorporating the antineoplastic nucleosides trifluridine and 2'-deoxy-5-fluorouridine into DNA.
Sakamoto K, Yokogawa T, Ueno H, Oguchi K, Kazuno H, Ishida K, Tanaka N, Osada A, Yamada Y, Okabe H, Matsuo K.
Int J Oncol · research-article; journal article · DOI 10.3892/ijo.2015.2974Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, together with bevacizumab, cetuximab, or panitumumab on human colorectal cancer xenografts.
Tsukihara H, Nakagawa F, Sakamoto K, Ishida K, Tanaka N, Okabe H, Uchida J, Matsuo K, Takechi T.
Oncol Rep · research-article; journal article · DOI 10.3892/or.2015.3876Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, with irinotecan hydrochloride on human colorectal and gastric cancer xenografts.
Nukatsuka M, Nakagawa F, Saito H, Sakata M, Uchida J, Takechi T.
Anticancer Res · journal articleRepeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models.
Tanaka N, Sakamoto K, Okabe H, Fujioka A, Yamamura K, Nakagawa F, Nagase H, Yokogawa T, Oguchi K, Ishida K, Osada A, Kazuno H, Yamada Y, Matsuo K.
Oncol Rep · research-article; journal article · DOI 10.3892/or.2014.3487Thymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer.
Lee SJ, Yeo JS, Lee HJ, Lee EJ, Kim SY, Jang SJ, Lee JJ, Ryu JS, Moon DH.
Eur J Nucl Med Mol Imaging · research support, non-u.s. gov't; journal article · DOI 10.1007/s00259-014-2712-z