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Publikationer som ChEBI hänvisar till för (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol. Visa hela publikationsregistret

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Publications in the selection

25 hits

Bibliografisk träff 2024-04-28

Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells.

Fatih Polat M, Durmaz Şahin I, Kul P, Cetin Atalay R, Tuncbilek M.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2024.129775

Bibliografisk träff 2024-01-13

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Zhang SM, Paulin CBJ, Shu H, Yagüe-Capilla M, Michel M, Marttila P, Ortis F, Bwanika HC, Dirks C, Venkatram RP, Wiita E, Jemth AS, Almlöf I, Loseva O, Hormann FM, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Axelsson H, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG.

iScience · research-article; journal article · DOI 10.1016/j.isci.2024.108907

Bibliografisk träff 2023-11-10

Newly synthesized 6-substituted piperazine/phenyl-9-cyclopentyl containing purine nucleobase analogs act as potent anticancer agents and induce apoptosis <i>via</i> inhibiting Src in hepatocellular carcinoma cells.

Bilget Guven E, Durmaz Sahin I, Altiparmak D, Servili B, Essiz S, Cetin-Atalay R, Tuncbilek M.

RSC Med Chem · research-article; journal article · DOI 10.1039/d3md00440f

Bibliografisk träff 2019-02-14

Lead optimization and biological evaluation of fragment-based cN-II inhibitors.

Guillon R, Rahimova R, Preeti, Egron D, Rouanet S, Dumontet C, Aghajari N, Jordheim LP, Chaloin L, Peyrottes S.

Eur J Med Chem · journal article · DOI 10.1016/j.ejmech.2019.02.040

Bibliografisk träff 2018-01-02

Synthesis of novel 6-substituted amino-9-(β-d-ribofuranosyl)purine analogs and their bioactivities on human epithelial cancer cells.

Tuncbilek M, Kucukdumlu A, Guven EB, Altiparmak D, Cetin-Atalay R.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/j.bmcl.2017.12.070

Bibliografisk träff 2015-01-20

SAR-guided development and characterization of a potent antitumor compound toward B-cell neoplasms with no detectable cytotoxicity toward healthy cells.

Brunhofer-Bolzer G, Le T, Dyckmanns N, Knaus HA, Pausz C, Freund P, Jäger U, Erker T, Vanura K.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm501848m

Bibliografisk träff 2015-01-08

Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.

Marada VV, Flörl S, Kühne A, Burckhardt G, Hagos Y.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2015.01.011

Bibliografisk träff 2014-10-30

Synthesis of novel substituted purine derivatives and identification of the cell death mechanism.

Demir Z, Guven EB, Ozbey S, Kazak C, Atalay RC, Tuncbilek M.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2014.10.080

Bibliografisk träff 2014-09-08

Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation.

Ferla S, Aboraia AS, Brancale A, Pepper CJ, Zhu J, Ochalek JT, DeLuca HF, Simons C.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm5009314

Bibliografisk träff 2014-06-10

Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies.

Stout EP, Choi MY, Castro JE, Molinski TF.

J Med Chem · research support, non-u.s. gov't; research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1021/jm4016922

Bibliografisk träff 2013-08-21

Stabilized cyclopropane analogs of the splicing inhibitor FD-895.

Villa R, Kashyap MK, Kashyap MK, Kumar D, Kipps TJ, Castro JE, La Clair JJ, Burkart MD.

J Med Chem · research support, non-u.s. gov't; research-article; journal article; research support, n.i.h., extramural · DOI 10.1021/jm400861t

Bibliografisk träff 2013-02-06

Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1.

Lepist EI, Damaraju VL, Zhang J, Gati WP, Yao SY, Smith KM, Karpinski E, Young JD, Leung KH, Cass CE.

Drug Metab Dispos · research support, non-u.s. gov't; journal article · DOI 10.1124/dmd.112.049858

Bibliografisk träff 2011-12-15

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.

PLoS Comput Biol · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1371/journal.pcbi.1002310

Bibliografisk träff 2011-11-04

Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides.

Hassan AE, Abou-Elkhair RA, Riordan JM, Allan PW, Parker WB, Khare R, Waud WR, Montgomery JA, Secrist JA.

Eur J Med Chem · research-article; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ejmech.2011.10.039

Bibliografisk träff 2010-05-12

Synthesis of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uridines and study of their cytotoxic activity.

Brulíková L, Dzubák P, Hajdúch M, Lachnitová L, Kollareddy M, Kolár M, Bogdanová K, Hlavác J.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2010.05.003

Bibliografisk träff 2010-01-06

QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.

Toropov AA, Toropova AP, Raska I, Benfenati E.

Eur J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1016/j.ejmech.2009.12.043

Bibliografisk träff 2008-10-04

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Santana L, González-Díaz H, Quezada E, Uriarte E, Yáñez M, Viña D, Orallo F.

J Med Chem · research support, non-u.s. gov't; journal article · DOI 10.1021/jm800656v

Bibliografisk träff 2008-04-21

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Obach RS, Lombardo F, Waters NJ.

Drug Metab Dispos · journal article · DOI 10.1124/dmd.108.020479

Bibliografisk träff 2007-05-25

Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria.

Sandrini MP, Shannon O, Clausen AR, Björck L, Piskur J.

Antimicrob Agents Chemother · research support, non-u.s. gov't; research-article; journal article · DOI 10.1128/aac.00081-07

Bibliografisk träff 2004-12-01

Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.

Matthews EJ, Kruhlak NL, Weaver JL, Benz RD, Contrera JF.

Curr Drug Discov Technol · journal article · DOI 10.2174/1570163043334794

Bibliografisk träff 2004-08-01

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs].

Biour M, Ben Salem C, Chazouillères O, Grangé JD, Serfaty L, Poupon R.

Gastroenterol Clin Biol · bibliography; journal article · DOI 10.1016/s0399-8320(04)95062-2

Bibliografisk träff 2003-03-01

Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines.

Bråthe A, Gundersen LL, Nissen-Meyer J, Rise F, Spilsberg B.

Bioorg Med Chem Lett · research support, non-u.s. gov't; journal article · DOI 10.1016/s0960-894x(03)00011-8

Bibliografisk träff 1995-03-01

Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.

Siddiqi SM, Jacobson KA, Esker JL, Olah ME, Ji XD, Melman N, Tiwari KN, Secrist JA, Schneller SW, Cristalli G.

J Med Chem · research support, u.s. gov't, p.h.s.; research-article; journal article · DOI 10.1021/jm00007a014

Bibliografisk träff 1992-01-01

Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.

Montgomery JA, Shortnacy-Fowler AT, Clayton SD, Riordan JM, Secrist JA.

J Med Chem · research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00080a029

Bibliografisk träff 1985-11-01

2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity.

Secrist JA, Shortnacy AT, Montgomery JA.

J Med Chem · comparative study; research support, u.s. gov't, p.h.s.; journal article · DOI 10.1021/jm00149a033