Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD<sup>+</sup> acute myeloid leukemia.
Zhou Q, Guan Y, Zhao P, Chu H, Xi Y.
Transl Oncol · research-article; journal article · DOI 10.1016/j.tranon.2025.102271 PUBLICATION REGISTRY
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29 hitsInhibiting H3K27 Demethylases Downregulates CREB-CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia.
Lazaro-Navarro J, Alcon C, Dorel M, Alasfar L, Bastian L, Baldus C, Astrahantseff K, Yaspo ML, Montero J, Eckert C.
Cancer Med · brief-report; journal article · DOI 10.1002/cam4.70596Suppression of the H3K27me3 demethylase disrupts diapause formation in mosquito Culex pipiens.
Wei X, Dhungana P, Callender K, Zewde B, Chen F, Kim SJ, Sim C.
Insect Biochem Mol Biol · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1016/j.ibmb.2024.104216Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B.
Shokry D, Khan MW, Powell C, Johnson S, Rennels BC, Boyd RI, Sun Z, Fazal Z, Freemantle SJ, Parker MH, Vieson MD, Samuelson JP, Spinella MJ, Singh R.
Cell Commun Signal · research-article; research support, u.s. gov't, non-p.h.s.; journal article; research support, n.i.h., extramural · DOI 10.1186/s12964-024-01912-3Intervention of inflammation associated with ankylosing spondylitis by triptolide promotes histone H3 Iys-27 trimethylation.
Xu XH, Zhang JX, Liu HX, Zhao Z, Jiang JY.
Immunopharmacol Immunotoxicol · journal article · DOI 10.1080/08923973.2024.2402911[Histone demethylase JMJD3 inhibits alveolar bone loss by regulating macrophage polarization in periodontitis].
Wang RL, Lu JW, Luo LJ.
Zhonghua Kou Qiang Yi Xue Za Zhi · journal article; english abstract · DOI 10.3760/cma.j.cn112144-20240129-00047miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes.
Salerno D, Peruzzi G, Giuseppe Rubens Pascucci, Levrero M, Belloni L, Pediconi N.
Gene · journal article · DOI 10.1016/j.gene.2024.148387Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer.
Pecci V, Troisi F, Aiello A, De Martino S, Carlino A, Fiorentino V, Ripoli C, Rotili D, Pierconti F, Martini M, Porru M, Pinto F, Mai A, Bassi PF, Grassi C, Gaetano C, Pontecorvi A, Strigari L, Farsetti A, Nanni S.
Cancer Cell Int · research-article; journal article · DOI 10.1186/s12935-024-03231-6Antitumoral Potential of the Histone Demethylase Inhibitor GSK-J4 in Retinoblastoma.
Zhang Y, Wu W, Xu C, Yang H, Huang G.
Invest Ophthalmol Vis Sci · research support, non-u.s. gov't; research-article; journal article · DOI 10.1167/iovs.65.2.34Targeting Esophageal Squamous Cell Carcinoma by Combining Copper Ionophore Disulfiram and JMJD3/UTX Inhibitor GSK J4.
Yang C, Li F, Ren Y, Zhang Q, Jiao B, Zhang J, Huang J.
Cancers (Basel) · journal article · DOI 10.3390/cancers15225347GSK-J4 Inhibition of KDM6B Histone Demethylase Blocks Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells by Modulating NF-κB Signaling.
Sadeghi L, Wright APH.
Cells · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/cells12152010Donafenib and GSK-J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression.
Zheng C, Zhang B, Li Y, Liu K, Wei W, Liang S, Guo H, Ma K, Liu Y, Wang J, Liu L.
Adv Sci (Weinh) · research support, non-u.s. gov't; research-article; journal article · DOI 10.1002/advs.202206798GSK-J4: An H3K27 histone demethylase inhibitor, as a potential anti-cancer agent.
Dalpatraj N, Naik A, Thakur N.
Int J Cancer · research support, non-u.s. gov't; review; journal article · DOI 10.1002/ijc.34559Role of Jumonji domain-containing protein D3 and its inhibitor GSK-J4 in Hashimoto's thyroiditis.
Lu X, Liu Y, Xu L, Liang H, Zhou X, Lei H, Sha L.
Open Med (Wars) · research-article; journal article · DOI 10.1515/med-2023-0659CCL17 Blockade by CCL17mAb/GSK-J4 Ameliorates Hyperalgesia in a Rat Model of Postoperative Pain.
Zhang Z, Zhang T, Zhang Y, Liang Y.
Biol Pharm Bull · journal article · DOI 10.1248/bpb.b22-00463Combination Treatment of a Phytochemical and a Histone Demethylase Inhibitor-A Novel Approach towards Targeting TGFβ-Induced EMT, Invasion, and Migration in Prostate Cancer.
Dalpatraj N, Naik A, Thakur N.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms24031860Targeting H3K27me3 demethylase to inhibit Shh signaling and cholesterol metabolism in medulloblastoma growth.
Deng H, Guo X, Feng N, Luo Y, Liu B, Liu S, Wu JI, Shi X.
Front Oncol · research-article; journal article · DOI 10.3389/fonc.2022.1057147The Histone Demethylase Inhibitor GSK-J4 Is a Therapeutic Target for the Kidney Fibrosis of Diabetic Kidney Disease via DKK1 Modulation.
Hung PH, Hsu YC, Chen TH, Ho C, Lin CL.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms23169407GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes <i>via</i> Preserving H3K27 Methylation and Reducing Ferroptosis.
Xu K, Liu X, Wen B, Liu Y, Zhang W, Hu X, Chen L, Hang W, Chen J.
Front Cardiovasc Med · research-article; journal article · DOI 10.3389/fcvm.2022.907747Effects of GSK-J4 on JMJD3 Histone Demethylase in Mouse Prostate Cancer Xenografts.
Sanchez A, Penault-Llorca F, Bignon YJ, Guy L, Bernard-Gallon D.
Cancer Genomics Proteomics · research-article; journal article · DOI 10.21873/cgp.20324The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells.
Doñas C, Neira J, Osorio-Barrios F, Carrasco M, Fernández D, Prado C, Loyola A, Pacheco R, Rosemblatt M.
Sci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/s41598-020-79122-3GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK-J4 and decitabine in acute myeloid leukemia KG-1a cells.
Chu X, Zhong L, Yu L, Xiong L, Li J, Dan W, Ye J, Liu C, Luo X, Liu B.
Cancer Cell Int · research-article; journal article · DOI 10.1186/s12935-020-01297-6Synergy of GSK-J4 With Doxorubicin in KRAS-Mutant Anaplastic Thyroid Cancer.
Lin B, Lu B, Hsieh IY, Liang Z, Sun Z, Yi Y, Lv W, Zhao W, Li J.
Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2020.00632Two old drugs, NVP-AEW541 and GSK-J4, repurposed against the Toxoplasma gondii RH strain.
Liu S, Wu M, Hua Q, Lu D, Tian Y, Yu H, Cheng L, Chen Y, Cao J, Hu X, Tan F.
Parasit Vectors · research-article; journal article · DOI 10.1186/s13071-020-04094-2The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays.
Lobo-Silva J, Cabral FJ, Amaral MS, Miyasato PA, de Freitas RP, Pereira ASA, Khouri MI, Barbosa MMF, Ramos PIP, Leite LCC, Asojo OA, Nakano E, Verjovski-Almeida S, Farias LP.
Parasit Vectors · research-article; journal article · DOI 10.1186/s13071-020-4000-zOncogenic KRAS Sensitizes Lung Adenocarcinoma to GSK-J4-Induced Metabolic and Oxidative Stress.
Hong BJ, Park WY, Kim HR, Moon JW, Lee HY, Park JH, Kim SK, Oh Y, Roe JS, Kim MY.
Cancer Res · journal article · DOI 10.1158/0008-5472.can-18-3511Antiproliferative effect of the histone demethylase inhibitor GSK-J4 in chondrosarcomas.
Lhuissier E, Aury-Landas J, Allas L, Boittin M, Boumediene K, Baugé C.
IUBMB Life · research support, non-u.s. gov't; journal article · DOI 10.1002/iub.2110GSK-J4-Mediated Transcriptomic Alterations in Differentiating Embryoid Bodies.
Mandal C, Kim SH, Kang SC, Chai JC, Lee YS, Jung KH, Chai YG.
Mol Cells · research-article; journal article · DOI 10.14348/molcells.2017.0069A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.
Nature · research support, non-u.s. gov't; research-article; journal article · DOI 10.1038/nature11262