A macrophage-cell model of HIV latency reveals the unusual importance of the bromodomain axis.
Kisaka JK, Rauch D, Griffith M, Kyei GB.
Virol J · research-article; journal article · DOI 10.1186/s12985-024-02343-9 PUBLICATION REGISTRY
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37 hitsSynthesis and characterization of I-BET151 derivatives for use in identifying protein targets in the African trypanosome.
Poli ANR, Blyn RC, Buenconsejo GY, Hodanu M, Tang E, Danh C, Cassel J, Debler EW, Schulz D, Salvino JM.
Curr Res Chem Biol · research-article; journal article · DOI 10.1016/j.crchbi.2023.100047A Functional Bayesian Model for Hydrogen-Deuterium Exchange Mass Spectrometry.
Crook OM, Gittens N, Chung CW, Deane CM.
J Proteome Res · research support, non-u.s. gov't; research-article; journal article · DOI 10.1021/acs.jproteome.3c00297Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome.
Ashby EC, Havens JL, Rollosson LM, Hardin J, Schulz D.
Microbiol Spectr · research-article; research support, u.s. gov't, non-p.h.s.; journal article · DOI 10.1128/spectrum.00147-23Bromodomain Protein Inhibitors Reorganize the Chromatin of Synovial Fibroblasts.
Krošel M, Moser L, Houtman M, Friščić J, Tomšič M, Distler O, Hoffmann MH, Ospelt C, Klein K.
Cells · research support, non-u.s. gov't; research-article; journal article · DOI 10.3390/cells12081149Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition.
Friščić J, Reinwald C, Böttcher M, Houtman M, Euler M, Chen X, Walker KI, Kirchner P, Zhu H, Wirth B, Weidner D, Krüger R, Trajkovic V, Ekici AB, Klein K, Mougiakakos D, Ospelt C, Schett G, Hoffmann MH.
Arthritis Rheumatol · research support, non-u.s. gov't; journal article · DOI 10.1002/art.42378Overexpression of Bromodomain and Extraterminal Domain is Associated with Progression, Metastasis and Unfavorable Outcomes: Highlighting Prognostic and Therapeutic Value of the BET Protein Family in Gastric Cancer.
Fard SS, Kouchaki S, Salimian Z, Sotoudeh M, Mousavi SA, Alimoghaddam K, Ghaffari SH.
Anticancer Agents Med Chem · research support, non-u.s. gov't; journal article · DOI 10.2174/1871520623666221025145320Retraction Note: BET inhibitor I-BET151 sensitizes GBM cells to temozolomide via PUMA induction.
Yao Z, Yang S, Zhao H, Yang H, Jiang X.
Cancer Gene Ther · retraction of publication; retraction notice · DOI 10.1038/s41417-022-00536-4Evaluation of the Synergistic Potential of Simultaneous Pan- or Isoform-Specific BET and SYK Inhibition in B-Cell Lymphoma: An In Vitro Approach.
Sender S, Sultan AW, Palmer D, Koczan D, Sekora A, Beck J, Schuetz E, Taher L, Brenig B, Fuellen G, Junghanss C, Murua Escobar H.
Cancers (Basel) · research-article; journal article · DOI 10.3390/cancers14194691Selective inhibitors of bromodomain BD1 and BD2 of BET proteins modulate radiation-induced profibrotic fibroblast responses.
Liu CS, Rioja I, Bakr A, Veldwijk MR, Sperk E, Herskind C, Weichenhan D, Prinjha RK, Plass C, Schmezer P, Popanda O.
Int J Cancer · research support, non-u.s. gov't; journal article · DOI 10.1002/ijc.33989Human expandable pancreatic progenitor-derived β cells ameliorate diabetes.
Ma X, Lu Y, Zhou Z, Li Q, Chen X, Wang W, Jin Y, Hu Z, Chen G, Deng Q, Shang W, Wang H, Fu H, He X, Feng XH, Zhu S.
Sci Adv · research support, non-u.s. gov't; research-article; journal article · DOI 10.1126/sciadv.abk1826Anticancer Effects of I-BET151, an Inhibitor of Bromodomain and Extra-Terminal Domain Proteins.
Lai J, Liu Z, Zhao Y, Ma C, Huang H.
Front Oncol · review-article; review; journal article · DOI 10.3389/fonc.2021.716830Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors.
Flynn NR, Ward MD, Schleiff MA, Laurin CMC, Farmer R, Conway SJ, Boysen G, Swamidass SJ, Miller GP.
Metabolites · research-article; journal article · DOI 10.3390/metabo11060390Pharmacologic Targeting of BET Proteins Attenuates Hyperuricemic Nephropathy in Rats.
Xiong C, Deng J, Wang X, Shao X, Zhou Q, Zou H, Zhuang S.
Front Pharmacol · research-article; journal article · DOI 10.3389/fphar.2021.636154Pan- and Isoform-specific Inhibition of the Bromodomain and Extra-terminal Proteins and Evaluation of Synergistic Potential With Entospletinib in Canine Lymphoma.
Kong W, Sender S, Perez SV, Sekora A, Ruetgen B, Junghanss C, Nolte I, Murua Escobar H.
Anticancer Res · journal article · DOI 10.21873/anticanres.14367Impact of structurally diverse BET inhibitors on SIRT1.
Tenhunen J, Kokkola T, Huovinen M, Rahnasto-Rilla M, Lahtela-Kakkonen M.
Gene · journal article · DOI 10.1016/j.gene.2020.144558Author Correction: BET inhibitor I-BET151 sensitizes GBM cells to temozolomide via PUMA induction.
Yao Z, Yang S, Zhao H, Yang H, Jiang X.
Cancer Gene Ther · published erratum · DOI 10.1038/s41417-019-0082-1Bromodomain inhibitor I-BET151 suppresses immune responses during fungal-immune interaction.
Domínguez-Andrés J, Ferreira AV, Jansen T, Smithers N, Prinjha RK, Furze RC, Netea MG.
Eur J Immunol · brief-report; research support, non-u.s. gov't; journal article · DOI 10.1002/eji.201848081I-BET151 suppresses osteoclast formation and inflammatory cytokines secretion by targetting BRD4 in multiple myeloma.
Guo NH, Zheng JF, Zi FM, Cheng J.
Biosci Rep · research support, non-u.s. gov't; research-article; journal article · DOI 10.1042/bsr20181245The BET Bromodomain Inhibitor I-BET-151 Induces Structural and Functional Alterations of the Heart Mitochondria in Healthy Male Mice and Rats.
Piquereau J, Boet A, Péchoux C, Antigny F, Lambert M, Gressette M, Ranchoux B, Gambaryan N, Domergue V, Mumby S, Montani D, Adcock IM, Humbert M, Garnier A, Rucker-Martin C, Perros F.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms20071527BET inhibitor I-BET151 sensitizes GBM cells to temozolomide via PUMA induction.
Yao Z, Yang S, Zhao H, Yang H, Jiang X.
Cancer Gene Ther · retracted publication; journal article · DOI 10.1038/s41417-018-0068-4BET Inhibition Improves NASH and Liver Fibrosis.
Middleton SA, Rajpal N, Cutler L, Mander P, Rioja I, Prinjha RK, Rajpal D, Agarwal P, Kumar V.
Sci Rep · research-article; journal article · DOI 10.1038/s41598-018-35653-4NF-κB signaling activation via increases in BRD2 and BRD4 confers resistance to the bromodomain inhibitor I-BET151 in U937 cells.
Hishiki K, Akiyama M, Kanegae Y, Ozaki K, Ohta M, Tsuchitani E, Kaito K, Yamada H.
Leuk Res · research support, non-u.s. gov't; journal article · DOI 10.1016/j.leukres.2018.09.016The BET bromodomain inhibitor i-BET151 impairs ovarian cancer metastasis and improves antitumor immunity.
Liu A, Fan D, Wang Y.
Cell Tissue Res · journal article · DOI 10.1007/s00441-018-2906-y[Role of BET Bromodomain in Hematopoietic Differentiation from hESCs].
Feng ZC, Wen YQ, Wang MG, Tu Q, Wang HT, Wang ZY, Zhou JX.
Zhongguo Shi Yan Xue Ye Xue Za Zhi · journal article · DOI 10.7534/j.issn.1009-2137.2018.04.040Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation.
Chabert C, Khochbin S, Rousseaux S, Veyrenc S, Furze R, Smithers N, Prinjha RK, Schlattner U, Pison C, Dubouchaud H.
Int J Mol Sci · research-article; journal article · DOI 10.3390/ijms19082224Bi-directional regulation of cartilage metabolism by inhibiting BET proteins-analysis of the effect of I-BET151 on human chondrocytes and murine joints.
Dai J, Zhou S, Ge Q, Qin J, Chen D, Xu Z, Shi D, Li J, Ju H, Cao Y, Zheng M, Li CJ, Gao X, Teng H, Jiang Q.
J Orthop Surg Res · research-article; journal article · DOI 10.1186/s13018-018-0797-yI‑BET151 inhibits osteoclastogenesis via the RANKL signaling pathway in RAW264.7 macrophages.
Cheng J, Zheng J, Guo N, Zi F.
Mol Med Rep · journal article · DOI 10.3892/mmr.2017.7631I-BET151 inhibits expression of RANKL, OPG, MMP3 and MMP9 in ankylosing spondylitis <i>in vivo</i> and <i>in vitro</i>.
Fan J, Zhao J, Shao J, Wei X, Zhu X, Li M.
Exp Ther Med · research-article; journal article · DOI 10.3892/etm.2017.5032The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts.
Klein K, Kabala PA, Grabiec AM, Gay RE, Kolling C, Lin LL, Gay S, Tak PP, Prinjha RK, Ospelt C, Reedquist KA.
Ann Rheum Dis · research support, non-u.s. gov't; journal article · DOI 10.1136/annrheumdis-2014-205809